PUBLICATION
Cardiovascular development: prospects for a genetic approach
- Authors
- Fishman, M.C. and Stainier, D.Y.R.
- ID
- ZDB-PUB-961014-307
- Date
- 1994
- Source
- Circulation research 74: 757-763 (Review)
- Registered Authors
- Fishman, Mark C., Stainier, Didier
- Keywords
- none
- MeSH Terms
-
- Animals
- Caenorhabditis elegans/embryology
- Caenorhabditis elegans/genetics
- Cardiovascular System/embryology
- Cell Differentiation/genetics
- Drosophila melanogaster/embryology
- Drosophila melanogaster/genetics
- Fishes/embryology
- Fishes/genetics
- Heart/embryology*
- Humans
- Morphogenesis
- Mutation/genetics
- Xenopus/embryology
- Xenopus/genetics
- PubMed
- 8156624 Full text @ Circ. Res.
Citation
Fishman, M.C. and Stainier, D.Y.R. (1994) Cardiovascular development: prospects for a genetic approach. Circulation research. 74:757-763.
Abstract
Genetics is a powerful tool, especially when used in combination with embryology, in the seeking of genes necessary for assembly of the cardiovasculature. The first questions must address the types of cellular decisions that are made during development. As for simpler systems in C elegans and D melanogaster, the lineage and cell-fate decisions of the cardiovascular progenitors need to be assessed. In addition it is likely that new paradigms will emerge for multicellular assembly. The study of cardiovascular mutations will define individual genetic steps that define organotypic decisions. A genetic approach is a natural extension of embryology, physiology, and anatomy, fields of great sophistication with regard to the cardiovasculature, because, like them, it focuses on integrative biology and on the intact organism. The zebrafish is particularly well suited to a combination genetic-embryologic study of the fashioning of the cardiovasculature.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping