PUBLICATION
Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
- Authors
- Kim, Y., Kim, S.S., Park, B.H., Hwang, K.S., Bae, M.A., Cho, S.H., Kim, S., Park, H.C.
- ID
- ZDB-PUB-230628-43
- Date
- 2023
- Source
- Toxics 11(6): (Journal)
- Registered Authors
- Park, Hae-Chul
- Keywords
- bisphenol F, locomotion, motor neuron, myelination, neurochemicals, zebrafish
- MeSH Terms
- none
- PubMed
- 37368577 Full text @ Toxics
Citation
Kim, Y., Kim, S.S., Park, B.H., Hwang, K.S., Bae, M.A., Cho, S.H., Kim, S., Park, H.C. (2023) Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish. Toxics. 11(6):.
Abstract
Bisphenol F (BPF; 4,4'-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping