PUBLICATION
Preparation and Characterization of Ginger Peel Polysaccharide-Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity
- Authors
- Li, W., Qiu, Z., Ma, Y., Zhang, B., Li, L., Li, Q., He, Q., Zheng, Z.
- ID
- ZDB-PUB-221224-11
- Date
- 2022
- Source
- Antioxidants (Basel, Switzerland) 11(12): (Journal)
- Registered Authors
- Keywords
- anti-inflammatory activity, ginger peel polysaccharide–Zn (II) complexes, structural characterization, synthesis, zebrafish
- MeSH Terms
- none
- PubMed
- 36552539 Full text @ Antioxidants (Basel)
Citation
Li, W., Qiu, Z., Ma, Y., Zhang, B., Li, L., Li, Q., He, Q., Zheng, Z. (2022) Preparation and Characterization of Ginger Peel Polysaccharide-Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity. Antioxidants (Basel, Switzerland). 11(12):.
Abstract
The present study aimed to explore the improvement of the bioactivity of ginger peel polysaccharides (GPs) by the modification of zinc after structural characterization. The obtained GP-Zn (II) complexes consisted dominantly of glucose and galactose in a mass proportion of 95.10:2.10, with a molecular weight of 4.90 × 105 Da and a Zn content of 21.17 mg/g. The chelation of GPs and Zn (II) was mainly involved in the O-H of hydroxyl groups, and this interaction reduced the crystallinity and decreased the asymmetry of GPs, with a slight effect on the thermal stability. The administration of GPs and their Zn (II) complexes effectively alleviated CuSO4-induced inflammatory response in zebrafish (Tg: zlyz-EGFP) via down-regulating the mRNA expression levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-12 and TNF-α) and upregulating the expression of anti-inflammatory cytokine (IL-10). Furthermore, the modification of Zn (II) enhanced the inflammation-inhibiting effect of polysaccharides. Therefore, GP-Zn (II) complexes could be applied as a candidate anti-inflammatory agent for the treatment of chronic inflammation-related diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping