PUBLICATION
Unmyelinated sensory neurons use Neuregulin signals to promote myelination of interneurons in the CNS
- Authors
- Lysko, D.E., Talbot, W.S.
- ID
- ZDB-PUB-221118-4
- Date
- 2022
- Source
- Cell Reports 41: 111669 (Journal)
- Registered Authors
- Talbot, William S.
- Keywords
- CP: Neuroscience, CRISPR, central nervous system, myelination, neuregulin1, oligodendrocyte, zebrafish
- MeSH Terms
-
- Animals
- Central Nervous System*
- Interneurons
- Myelin Sheath/metabolism
- Sensory Receptor Cells/physiology
- Zebrafish*
- PubMed
- 36384112 Full text @ Cell Rep.
Citation
Lysko, D.E., Talbot, W.S. (2022) Unmyelinated sensory neurons use Neuregulin signals to promote myelination of interneurons in the CNS. Cell Reports. 41:111669.
Abstract
The signaling mechanisms neurons use to modulate myelination of circuits in the central nervous system (CNS) are only partly understood. Through analysis of isoform-specific neuregulin1 (nrg1) mutants in zebrafish, we demonstrate that nrg1 type II is an important regulator of myelination of two classes of spinal cord interneurons. Surprisingly, nrg1 type II expression is prominent in unmyelinated Rohon-Beard sensory neurons, whereas myelination of neighboring interneurons is reduced in nrg1 type II mutants. Cell-type-specific loss-of-function studies indicate that nrg1 type II is required in Rohon-Beard neurons to signal to other neurons, not oligodendrocytes, to modulate spinal cord myelination. Together, our data support a model in which unmyelinated neurons express Nrg1 type II proteins to regulate myelination of neighboring neurons, a mode of action that may coordinate the functions of unmyelinated and myelinated neurons in the CNS.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping