PUBLICATION
Dopamine Level Affects Social Interaction and Color Preference Possibly Through Intestinal Microbiota in Zebrafish
- Authors
- Wang, J., Zheng, F., Yin, L., Shi, S., Hu, B., Qu, H., Zheng, L.
- ID
- ZDB-PUB-220616-6
- Date
- 2022
- Source
- Zebrafish 19: 81-93 (Journal)
- Registered Authors
- Hu, Bing
- Keywords
- color preference, dopamine, intestinal microbiota, social interaction, zebrafish
- MeSH Terms
-
- Animals
- Dopamine
- Gastrointestinal Microbiome*
- Lacticaseibacillus rhamnosus*
- Social Behavior
- Social Interaction
- Zebrafish
- PubMed
- 35704897 Full text @ Zebrafish
Citation
Wang, J., Zheng, F., Yin, L., Shi, S., Hu, B., Qu, H., Zheng, L. (2022) Dopamine Level Affects Social Interaction and Color Preference Possibly Through Intestinal Microbiota in Zebrafish. Zebrafish. 19:81-93.
Abstract
Accumulating researches suggest that the microbiota reside in the gastrointestinal system can influence neurodevelopment of brain and programming of behaviors. However, the mechanism underlining the relationship between shoals' behaviors and intestinal microbiota remain controversial and the roles of responsible neurotransmitters are still unclear. Here we show that shoaling behavior affected the color preference of shoals, indicating that shoals tended to choose a favorable color environment that benefited social contact. Meanwhile, administration of the selective D1-R antagonist, SCH23390, could disrupt the social interaction that led to the deficits of color preference in shoals. More importantly, the altered microbiota caused by an antibiotic oxytetracycline (OTC) exposure decreased the sociability and weakened shoals' preference for all color combinations. When given a supplementation of Lactobacillus rhamnosus GG after OTC exposure, fish maintained the same capability of social cohesion and color preference as normal fish. Our results support a role for dopamine in shaping the color preference in shoals. Our findings show that dopamine level of brain could mediate both social recognition and color preference, and offer a possibility that the production of dopamine is coordinated through gut microbiota.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping