PUBLICATION
Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish
- Authors
- Chuang, H.J., Chang, C.Y., Ho, H.P., Chou, M.Y.
- ID
- ZDB-PUB-210728-4
- Date
- 2021
- Source
- International Journal of Molecular Sciences 22(14): (Journal)
- Registered Authors
- Chou, Ming-Yi
- Keywords
- environmental markers, environmental stressors, oxytocin receptor, oxytocin system, stress, zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Behavior, Animal/drug effects*
- Brain/drug effects
- Brain/pathology*
- Environment
- Neurons/drug effects
- Neurons/pathology*
- Oxytocics/pharmacology*
- Oxytocin/pharmacology*
- Stress, Physiological*
- Zebrafish
- PubMed
- 34299078 Full text @ Int. J. Mol. Sci.
Citation
Chuang, H.J., Chang, C.Y., Ho, H.P., Chou, M.Y. (2021) Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish. International Journal of Molecular Sciences. 22(14):.
Abstract
The oxytocin system plays a role in stress responses and behavior modulation. However, the effects of oxytocin signaling on stress adaptation remain unclear. Here, we demonstrated the roles of oxytocin signaling as a biomarker under stress conditions in the peripheral tissues (the gills) and central nervous system (the brain). All the environmental stressors downregulated the expression of oxytocin receptors in the gills, and the alteration of the expression of oxytocin receptors was also found in the brain after the acidic (AC) and high-ammonia (HA) treatments. The number of oxytocin neurons was increased after double-deionized (DI) treatment. By transgenic line, Tg(oxtl:EGFP), we also investigated the projections of oxytocin neurons and found oxytocin axon innervations in various nuclei that might regulate the anxiety levels and aggressiveness of adult zebrafish under different environmental stresses. The oxytocin system integrates physiological responses and behavioral outcomes to ensure environmental adaptation in adult zebrafish. Our study provides insight into oxytocin signaling as a stress indicator upon environmental stressors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping