PUBLICATION
Effects of SiO2 nanoparticles on the uptake of tetrabromobisphenol A and its impact on the thyroid endocrine system in zebrafish larvae
- Authors
- Zhu, B., Han, J., Lei, L., Hua, J., Zuo, Y., Zhou, B.
- ID
- ZDB-PUB-210103-5
- Date
- 2020
- Source
- Ecotoxicology and environmental safety 209: 111845 (Journal)
- Registered Authors
- Keywords
- Bioaccumulation, Co-exposure, N-SiO(2), TBBPA, Thyroid disruption, Zebrafish larvae
- MeSH Terms
-
- Animals
- Endocrine System/drug effects
- Endocrine System/metabolism
- Larva/drug effects
- Nanoparticles/toxicity*
- Polybrominated Biphenyls/metabolism*
- Polybrominated Biphenyls/toxicity
- Silicon Dioxide/toxicity*
- Thyroid Gland/drug effects
- Thyroid Hormones/metabolism
- Water Pollutants, Chemical/metabolism*
- Water Pollutants, Chemical/toxicity
- Zebrafish/metabolism
- Zebrafish/physiology
- PubMed
- 33385677 Full text @ Ecotoxicol. Environ. Saf.
Citation
Zhu, B., Han, J., Lei, L., Hua, J., Zuo, Y., Zhou, B. (2020) Effects of SiO2 nanoparticles on the uptake of tetrabromobisphenol A and its impact on the thyroid endocrine system in zebrafish larvae. Ecotoxicology and environmental safety. 209:111845.
Abstract
The coexistence of nanoparticles and organic toxicants in the environment modifies pollutant bioavailability and toxicity. This study investigated the influence of silicon dioxide nanoparticles (n-SiO2) on the uptake of tetrabromobisphenol A (TBBPA) and its impact on the thyroid endocrine system in zebrafish larvae. Zebrafish (Danio rerio) embryos were exposed to TBBPA at different concentrations (50, 100, and 200 μg/L) alone or in combination with n-SiO2 (25 mg/L) until 120 h post-fertilization (hpf). Chemical measurements showed that both TBBPA and n-SiO2 were bioconcentrated in zebrafish larvae, and the uptake of TBBPA was enhanced by n-SiO2. Furthermore, zebrafish larvae exposed to 200 μg/L TBBPA alone exhibited significantly increased T4 contents and decreased T3 contents, whereas n-SiO2 treatment alone did not have a detectable effect. Furthermore, the thyroid hormone levels changed more upon treatment with 200 μg/L TBBPA combined with 25 mg/L n-SiO2 than upon TBBPA treatment alone. Alterations in gene transcription along the related hypothalamic-pituitary-thyroid (HPT) axis were observed, and expression of the binding and transport protein transthyretin (TTR) was significantly decreased for both TBBPA alone and co-exposure with n-SiO2. Thus, the current study demonstrates that n-SiO2, even at the nontoxic concentrations, increases thyroid hormone disruption in zebrafish larvae co-exposed to TBBPA by promoting its bioaccumulation and bioavailability.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping