|ZFIN ID: ZDB-PUB-200704-6|
In vivo generation and regeneration of β cells in zebrafish
Yang, B., Covington, B.A., Chen, W.
|Source:||Cell regeneration (London, England) 9: 9 (Review)|
|Registered Authors:||Chen, Wenbiao|
|PubMed:||32613468 Full text @ Cell Regen (Lond)|
Yang, B., Covington, B.A., Chen, W. (2020) In vivo generation and regeneration of β cells in zebrafish. Cell regeneration (London, England). 9:9.
ABSTRACTThe pathological feature of diabetes, hyperglycemia, is a result of an inadequate number and/or function of insulin producing β cells. Replenishing functional β cells is a strategy to cure the disease. Although β-cell regeneration occurs in animal models under certain conditions, human β cells are refractory to proliferation. A better understanding of both the positive and the negative regulatory mechanisms of β-cell regeneration in animal models is essential to develop novel strategies capable of inducing functional β cells in patients. Zebrafish are an attractive model system for studying β-cell regeneration due to the ease to which genetic and chemical-genetic approaches can be used as well as their high regenerative capacity. Here, we highlight the current state of β-cell regeneration studies in zebrafish with an emphasis on cell signaling mechanisms.
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