ZFIN ID: ZDB-PUB-200704-6
In vivo generation and regeneration of β cells in zebrafish
Yang, B., Covington, B.A., Chen, W.
Date: 2020
Source: Cell regeneration (London, England)   9: 9 (Review)
Registered Authors: Chen, Wenbiao
Keywords: none
MeSH Terms: none
PubMed: 32613468 Full text @ Cell Regen (Lond)
The pathological feature of diabetes, hyperglycemia, is a result of an inadequate number and/or function of insulin producing β cells. Replenishing functional β cells is a strategy to cure the disease. Although β-cell regeneration occurs in animal models under certain conditions, human β cells are refractory to proliferation. A better understanding of both the positive and the negative regulatory mechanisms of β-cell regeneration in animal models is essential to develop novel strategies capable of inducing functional β cells in patients. Zebrafish are an attractive model system for studying β-cell regeneration due to the ease to which genetic and chemical-genetic approaches can be used as well as their high regenerative capacity. Here, we highlight the current state of β-cell regeneration studies in zebrafish with an emphasis on cell signaling mechanisms.