ZFIN ID: ZDB-PERS-970929-1
Chen, Wenbiao
Email: Wenbiao.chen@vanderbilt.edu
URL:
Affiliation: Chen Lab
Address: 8425B MRB IV Dept of Molecular Physiology & Biophysics Vanderbilt Medical Center 2213 Garland Ave Nashville, TN 37232 USA
Country: United States
Phone: (615) 936-8126
Fax:
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Dean, E.D., Li, M., Prasad, N., Wisniewski, S.N., Von Deylen, A., Spaeth, J., Maddison, L., Botros, A., Sedgeman, L.R., Bozadjieva, N., Ilkayeva, O., Coldren, A., Poffenberger, G., Shostak, A., Semich, M.C., Aamodt, K.I., Phillips, N., Yan, H., Bernal-Mizrachi, E., Corbin, J.D., Vickers, K.C., Levy, S.E., Dai, C., Newgard, C., Gu, W., Stein, R., Chen, W., Powers, A.C. (2017) Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. Cell Metabolism. 25:1362-1373.e5
Li, M., Zhao, L., Page-McCaw, P.S., Chen, W. (2016) Zebrafish Genome Engineering Using the CRISPR-Cas9 System. Trends in genetics : TIG. 32(12):815-827
Michel, M., Page-McCaw, P.S., Chen, W., Cone, R.D. (2016) Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 113(11):3084-9
Lin, C.Y., Erkek, S., Tong, Y., Yin, L., Federation, A.J., Zapatka, M., Haldipur, P., Kawauchi, D., Risch, T., Warnatz, H.J., Worst, B.C., Ju, B., Orr, B.A., Zeid, R., Polaski, D.R., Segura-Wang, M., Waszak, S.M., Jones, D.T., Kool, M., Hovestadt, V., Buchhalter, I., Sieber, L., Johann, P., Chavez, L., Gröschel, S., Ryzhova, M., Korshunov, A., Chen, W., Chizhikov, V.V., Millen, K.J., Amstislavskiy, V., Lehrach, H., Yaspo, M.L., Eils, R., Lichter, P., Korbel, J.O., Pfister, S.M., Bradner, J.E., Northcott, P.A. (2016) Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. 530:57-62
Li, M., Page-McCaw, P., Chen, W. (2016) FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes. 65(1):96-109
Yin, L., Maddison, L.A., Chen, W. (2016) Multiplex conditional mutagenesis in zebrafish using the CRISPR/Cas system. Methods in cell biology. 135:3-17
Li, M., Dean, E.D., Zhao, L., Nicholson, W.E., Powers, A.C., Chen, W. (2015) Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. The Journal of endocrinology. 227:93-103
Zou, P., Wu, S.Y., Koteiche, H.A., Mishra, S., Levic, D.S., Knapik, E., Chen, W., Mchaourab, H.S. (2015) A conserved role of αA-crystallin in the development of the zebrafish embryonic lens. Experimental Eye Research. 138:104-13
Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
Yin, L., Maddison, L.A., Li, M., Kara, N., LaFave, M.C., Varshney, G.K., Burgess, S.M., Patton, J.G., Chen, W. (2015) Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. Genetics. 200(2):431-41
Maddison, L.A., Joest, K.E., Kammeyer, R.M., Chen, W. (2015) Skeletal muscle insulin resistance in zebrafish induces alterations in β-cell number and glucose tolerance in an age and diet dependent manner. American journal of physiology. Endocrinology and metabolism. 308(8):E662-9
Huang, J., Zhong, Z., Wang, M., Chen, X., Tan, Y., Zhang, S., He, W., He, X., Huang, G., Lu, H., Wu, P., Che, Y., Yan, Y.L., Postlethwait, J.H., Chen, W., Wang, H. (2015) Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:2572-87
Ju, B., Chen, W., Orr, B.A., Spitsbergen, J.M., Jia, S., Eden, C.J., Henson, H.E., Taylor, M.R. (2015) Oncogenic KRAS promotes malignant brain tumors in zebrafish. Molecular Cancer. 14:18
Yin, L., Jao, L.E., Chen, W. (2015) Generation of Targeted Mutations in Zebrafish Using the CRISPR/Cas System. Methods in molecular biology (Clifton, N.J.). 1332:205-17
Dirian, L., Galant, S., Coolen, M., Chen, W., Bedu, S., Houart, C., Bally-Cuif, L., Foucher, I. (2014) Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells. Developmental Cell. 30(2):123-36
Li, M., Maddison, L.A., Page-McCaw, P., and Chen, W. (2014) Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae.. American journal of physiology. Endocrinology and metabolism. 306(7):E799-807
Ju, B., Chen, W., Spitsbergen, J.M., Lu, J., Vogel, P., Peters, J.L., Wang, Y.D., Orr, B.A., Wu, J., Henson, H.E., Jia, S., Parupalli, C., Taylor, M.R. (2014) Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway. Oncogenesis. 3:e96
Maddison, L.A., Li, M., and Chen, W. (2014) Conditional gene-trap mutagenesis in zebrafish. Meth. Mol. Biol.. 1101:393-411
Jao, L.E., Wente, S.R., and Chen, W. (2013) Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc. Natl. Acad. Sci. USA. 110(34):13904-13909
Li, M., Maddison, L.A., Crees, Z., and Chen, W. (2013) Targeted Overexpression of CKI-Insensitive Cyclin-Dependent Kinase 4 Increases Functional β-Cell Number Through Enhanced Self-Replication in Zebrafish. Zebrafish. 10(2):170-6
Maddison, L.A., and Chen, W. (2012) Nutrient Excess Stimulates β-Cell Neogenesis in Zebrafish. Diabetes. 61(10):2517-2524
Ni, T.T., Lu, J., Zhu, M., Maddison, L.A., Boyd, K.L., Huskey, L., Ju, B., Hesselson, D., Zhong, T.P., Page-McCaw, P.S., Stainier, D.Y., and Chen, W. (2012) Conditional control of gene function by an invertible gene trap in zebrafish. Proc. Natl. Acad. Sci. USA. 109(38):15389-15394
Lu, J., Maddison, L.A., and Chen, W. (2011) PhiC31 integrase induces efficient site-specific excision in zebrafish. Transgenic Research. 20(1):183-189
Maddison, L.A., Lu, J., and Chen, W. (2011) Generating Conditional Mutations in Zebrafish Using Gene-trap Mutagenesis. Meth. Cell. Biol.. 104:1-22
Zhang, C., Song, Y., Thompson, D.A., Madonna, M.A., Millhauser, G.L., Toro, S., Varga, Z., Westerfield, M., Gamse, J., Chen, W., Cone, R.D. (2010) Pineal-specific agouti protein regulates teleost background adaptation. Proceedings of the National Academy of Sciences of the United States of America. 107(47):20164-71
Boniface, E.J., Lu, J., Victoroff, T., Zhu, M., and Chen, W. (2009) FlEx-based transgenic reporter lines for visualization of Cre and Flp activity in live zebrafish. Genesis (New York, N.Y. : 2000). 47(7):484-491
Ju, B., Spitsbergen, J., Eden, C.J., Taylor, M.R., and Chen, W. (2009) Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Molecular Cancer. 8:40
Maddison, L.A., Lu, J., Victoroff, T., Scott, E., Baier, H., and Chen, W. (2009) A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Molecular genetics and genomics : MGG. 281(5):551-563
Jao, L.E., Maddison, L., Chen, W., and Burgess, S.M. (2008) Using retroviruses as a mutagenesis tool to explore the zebrafish genome. Briefings in functional genomics & proteomics. 7(6):427-443
Chen, W.Y., John, J.A., Lin, C.H., and Chang, C.Y. (2007) Expression pattern of metallothionein, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium. Environmental toxicology and chemistry. 26(1):110-117
Wan, L., Almers, W., and Chen, W. (2005) Two ribeye Genes in Teleosts: The Role of Ribeye in Ribbon Formation and Bipolar Cell Development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(4):941-949
Chen, W., and Casey Corliss, D. (2004) Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis. Developmental Biology. 267(2):361-373
Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140
Chen, W.B., Burgess, S., Golling, G., Amsterdam, A., and Hopkins, N. (2002) High-throughput selection of retrovirus producer cell lines leads to markedly improved efficiency of germ line-transmissible insertions in zebra fish. Journal of virology. 76(5):2192-2198
Burgess, S., Reim, G., Chen, W., Hopkins, N., and Brand, M. (2002) The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis. Development (Cambridge, England). 129(4):905-916
Chen, W., Burgess, S., and Hopkins, N. (2001) Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development (Cambridge, England). 128(12):2385-2396
Amsterdam, A., Burgess, S., Golling, G., Chen, W., Sun, Z., Townsend, K., Farrington, S., Haldi, M., and Hopkins, N. (1999) A large-scale insertional mutagenesis screen in zebrafish. Genes and Development. 13(20):2713-2724

NON-ZEBRAFISH PUBLICATIONS