PUBLICATION
Seizing the moment: Zebrafish epilepsy models
- Authors
- Gawel, K., Langlois, M., Martins, T., van der Ent, W., Tiraboschi, E., Jacmin, M., Crawford, A.D., Esguerra, C.V.
- ID
- ZDB-PUB-200617-23
- Date
- 2020
- Source
- Neuroscience and biobehavioral reviews 116: 1-20 (Review)
- Registered Authors
- Crawford, Alexander, Esguerra, Camila V., Gawel, Kinga Aurelia, van der Ent, Wietske
- Keywords
- EEG, epilepsy, gene, high-throughput screening, pharmacological models, zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Epilepsy*/genetics
- Seizures
- Zebrafish*
- PubMed
- 32544542 Full text @ Neurosci. Biobehav. Rev.
Citation
Gawel, K., Langlois, M., Martins, T., van der Ent, W., Tiraboschi, E., Jacmin, M., Crawford, A.D., Esguerra, C.V. (2020) Seizing the moment: Zebrafish epilepsy models. Neuroscience and biobehavioral reviews. 116:1-20.
Abstract
Zebrafish are now widely accepted as a valuable animal model for a number of different central nervous system (CNS) diseases. They are suitable both for elucidating the origin of these disorders and the sequence of events culminating in their onset, and for use as a high-throughput in vivo drug screening platform. The availability of powerful and effective techniques for genome manipulation allows the rapid modelling of different genetic epilepsies and of conditions with seizures as a core symptom. With this review, we seek to summarize the current knowledge about existing epilepsy/seizures models in zebrafish (both pharmacological and genetic) and compare them with equivalent rodent and human studies. New findings obtained from the zebrafish models are highlighted. We believe that this comprehensive review will highlight the value of zebrafish as a model for investigating different aspects of epilepsy and will help researchers to use these models to their full extent.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping