ZFIN ID: ZDB-PERS-970617-23
Crawford, Alexander
Address: MPI fur Entwicklungsbiologie Spemanstrasse 35/I Tubingen, D-72076 Germany
Phone: 49-7071-601-335
Fax: 49-7071-601-305

Zebrafish genomics.

Soliman, R., Cordero-Maldonado, M.L., Martins, T.G., Moein, M., Conrotte, J.F., Warmack, R.A., Skupin, A., Crawford, A.D., Clarke, S.G., Linster, C.L. (2021) l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain. Frontiers in genetics. 11:612343
Gawel, K., Langlois, M., Martins, T., van der Ent, W., Tiraboschi, E., Jacmin, M., Crawford, A.D., Esguerra, C.V. (2020) Seizing the moment: Zebrafish epilepsy models. Neuroscience and biobehavioral reviews. 116:1-20
Brillatz, T., Jacmin, M., Vougogiannopoulou, K., Petrakis, E.A., Kalpoutzakis, E., Houriet, J., Pellissier, L., Rutz, A., Marcourt, L., Queiroz, E.F., Crawford, A.D., Skaltsounis, A.L., Wolfender, J.L. (2020) Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles. Journal of ethnopharmacology. 259:112954
Wronikowska, O., Michalak, A., Skalicka-Woźniak, K., Crawford, A.D., Budzyńska, B. (2019) Fishing for a deeper understanding of nicotine effects using zebrafish behavioural models. Progress in neuro-psychopharmacology & biological psychiatry. 98:109826
Copmans, D., Kildgaard, S., Rasmussen, S.A., Ślęzak, M., Dirkx, N., Partoens, M., Esguerra, C.V., Crawford, A.D., Larsen, T.O., de Witte, P.A.M. (2019) Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B. Marine drugs. 17(11):
Heins-Marroquin, U., Jung, P.P., Cordero-Maldonado, M.L., Crawford, A.D., Linster, C.L. (2019) Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency. Brain communications. 1:fcz019
Cordero-Maldonado, M.L., Perathoner, S., van der Kolk, K.J., Boland, R., Heins-Marroquin, U., Spaink, H.P., Meijer, A.H., Crawford, A.D., de Sonneville, J. (2019) Deep learning image recognition enables efficient genome editing in zebrafish by automated injections. PLoS One. 14:e0202377
Kozioł, E., Deniz, F.S.S., Orhan, I.E., Marcourt, L., Budzyńska, B., Wolfender, J.L., Crawford, A.D., Skalicka-Woźniak, K. (2018) High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 54:259-264
Aourz, N., Serruys, A.K., Chabwine, J., Balegamire, P.B., Afrikanova, T., Edrada-Ebel, R., Gray, A.I., Kamuhabwa, A.R., Walrave, L., Esguerra, C.V., van Leuven, F., de Witte, P.A.M., Smolders, I., Crawford, A.D. (2018) Identification of GSK-3 as a potential therapeutic entry point for epilepsy. ACS Chemical Neuroscience. 10(4):1992-2003
Brillatz, T., Lauritano, C., Jacmin, M., Khamma, S., Marcourt, L., Righi, D., Romano, G., Esposito, F., Ianora, A., Queiroz, E.F., Wolfender, J.L., Crawford, A.D. (2018) Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi. PLoS One. 13:e0196195
Köglsberger, S., Cordero-Maldonado, M.L., Antony, P., Forster, J.I., Garcia, P., Buttini, M., Crawford, A., Glaab, E. (2017) Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies. Molecular neurobiology. 54(10):7979-7993
Veitía, M.S., Mota, D.S., Lerari, V., Marín, M., Giner, R.M., Muro, L.V., Guerra, Y.R., Dumas, F., Ferroud, C., de Witte, P.A.M., Crawford, A.D., Arán, V.J., Ponce, Y.M. (2017) Fishing Anti-Inflammatories from Known Drugs: In Silico Repurposing, Design, Synthesis and Biological Evaluation of Bisacodyl Analogues. Current topics in medicinal chemistry.
Brillatz, T., Ferreira Queiroz, E., Marcourt, L., Jacmin, M., Crawford, A.D., Wolfender, J.L. (2016) Anticonvulsant agents from Boswellia sacra identified by zebrafish bioassay-guided fractionation. Planta Medica. 81:S1-S381
Brillatz, T., Ferreira Queiroz, E., Marcourt, L., Vougogiannopoulou, K., Jacmin, M., Crawford, A.D., Skaltsounis, L., Wolfender, J.L. (2016) Bioguided isolation of anticonvulsant principles from Helleborus cyclophyllus using the zebrafish epilepsy model. Planta Medica. 81:S1-S381
West, K.H., Crawford, A.D. (2016) Marine Biodiscovery Goes Deeper: Using In Vivo Bioassays Based on Model Organisms to Identify Biomedically Relevant Marine Metabolites. Planta Medica. 82(9-10):754-60
Perathoner, S., Cordero-Maldonado, M.L., Crawford, A.D. (2016) Potential of zebrafish as a model for exploring the role of the amygdala in emotional memory and motivational behavior. Journal of neuroscience research. 94(6):445-62
Mesens, N., Crawford, A.D., Menke, A., Hung, P.D., Van Goethem, F., Nuyts, R., Hansen, E., Wolterbeek, A., Van Gompel, J., De Witte, P., Esguerra, C.V. (2015) Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?. Journal of applied toxicology : JAT. 35(9):1017-29
Zhang, Y., Kecskés, A., Copmans, D., Langlois, M., Crawford, A.D., Ceulemans, B., Lagae, L., de Witte, P.A., Esguerra, C.V. (2015) Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine. PLoS One. 10:e0125898
Galizia, E.C., Myers, C.T., Leu, C., de Kovel, C.G., Afrikanova, T., Cordero-Maldonado, M.L., Martins, T.G., Jacmin, M., Drury, S., Krishna Chinthapalli, V., Muhle, H., Pendziwiat, M., Sander, T., Ruppert, A.K., Møller, R.S., Thiele, H., Krause, R., Schubert, J., Lehesjoki, A.E., Nürnberg, P., Lerche, H., EuroEPINOMICS CoGIE Consortium, Palotie, A., Coppola, A., Striano, S., Gaudio, L.D., Boustred, C., Schneider, A.L., Lench, N., Jocic-Jakubi, B., Covanis, A., Capovilla, G., Veggotti, P., Piccioli, M., Parisi, P., Cantonetti, L., Sadleir, L.G., Mullen, S.A., Berkovic, S.F., Stephani, U., Helbig, I., Crawford, A.D., Esguerra, C.V., Kasteleijn-Nolst Trenité, D.G., Koeleman, B.P., Mefford, H.C., Scheffer, I.E., Sisodiya, S.M. (2015) CHD2 variants are a risk factor for photosensitivity in epilepsy. Brain : a journal of neurology. 138(Pt 5):1198-207
Leclercq, K., Afrikanova, T., Langlois, M., De Prins, A., Buenafe, O.E., Rospo, C.C., Van Eeckhaut, A., de Witte, P.A., Crawford, A.D., Smolders, I., Esguerra, C.V., Kaminski, R.M. (2015) Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. Epilepsy & behavior : E&B. 45:53-63
Schubert, J., Siekierska, A., Langlois, M., May, P., Huneau, C., Becker, F., Muhle, H., Suls, A., Lemke, J.R., de Kovel, C.G., Thiele, H., Konrad, K., Kawalia, A., Toliat, M.R., Sander, T., Rüschendorf, F., Caliebe, A., Nagel, I., Kohl, B., Kecskés, A., Jacmin, M., Hardies, K., Weckhuysen, S., Riesch, E., Dorn, T., Brilstra, E.H., Baulac, S., Møller, R.S., Hjalgrim, H., Koeleman, B.P., EuroEPINOMICS RES Consortium, Jurkat-Rott, K., Lehman-Horn, F., Roach, J.C., Glusman, G., Hood, L., Galas, D.J., Martin, B., de Witte, P.A., Biskup, S., De Jonghe, P., Helbig, I., Balling, R., Nürnberg, P., Crawford, A.D., Esguerra, C.V., Weber, Y.G., Lerche, H. (2014) Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes. Nature Genetics. 46(12):1327-32
Challal, S., Buenafe, O.E., Queiroz, E.F., Maljevic, S., Marcourt, L., Bock, M., Kloeti, W., Dayrit, F.M., Harvey, A.L., Lerche, H., Esguerra, C.V., de Witte, P.A., Wolfender, J.L., Crawford, A.D. (2014) Zebrafish-bioassay guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum. ACS Chemical Neuroscience. 5(10):993-1004
Siverio-Mota, D., Andujar, I., Marrero-Ponce, Y., Giner, R.M., Vicet-Muro, L., Cordero-Maldonado, M.L., de Witte, P.A., Crawford, A.D., Veitía, M.S., Pérez-Jiménez, F., Aran, V.J. (2014) Pharmacological Evaluation of the Anti-Inflammatory Activity and Chemoinformatic Analysis of New Potent 2-Substituted 1-Methyl-5-Nitroindazolinones. Current topics in medicinal chemistry. 14(999)
Carballeira, N.M., Bwalya, A.G., Itoe, M.A., Andricopulo, A.D., Cordero-Maldonado, M.L., Kaiser, M., Mota, M.M., Crawford, A.D., Guido, R.V., Tasdemir, D. (2014) 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes. Bioorganic & medicinal chemistry letters. 24(17):4151-7
Buenafe, O.E., Orellana Paucar, A.M., Maes, J., Huang, H., De Borggraeve, W.M., Crawford, A.D., Luyten, W., Esguerra, C.V., and de Witte, P. (2013) Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ACS Chemical Neuroscience. 4(11):1479-87
Suls, A., Jaehn, J.A., Kecskés, A., Weber, Y., Weckhuysen, S., Craiu, D.C., Siekierska, A., Djémié, T., Afrikanova, T., Gormley, P., von Spiczak, S., Kluger, G., Iliescu, C.M., Talvik, T., Talvik, I., Meral, C., Caglayan, H.S., Giraldez, B.G., Serratosa, J., Lemke, J.R., Hoffman-Zacharska, D., Szczepanik, E., Barisic, N., Komarek, V., Hjalgrim, H., Møller, R.S., Linnankivi, T., Dimova, P., Striano, P., Zara, F., Marini, C., Guerrini, R., Depienne, C., Baulac, S., Kuhlenbäumer, G., Crawford, A.D., Lehesjoki, A.E., de Witte, P.A., Palotie, A., Lerche, H., Esguerra, C.V., De Jonghe, P., and Helbig, I. (2013) De Novo Loss-of-Function Mutations in CHD2 Cause a Fever-Sensitive Myoclonic Epileptic Encephalopathy Sharing Features with Dravet Syndrome. American journal of human genetics. 93(5):967-975
Cordero-Maldonado, M.L., Siverio-Mota, D., Vicet-Muro, L., Wilches-Arizábala, I.M., Esguerra, C.V., de Witte, P.A., and Crawford, A.D. (2013) Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolites. PLoS One. 8(10):e75404
Lauinger, I.L., Vivas, L., Perozzo, R., Stairiker, C., Tarun, A., Zloh, M., Zhang, X., Xu, H., Tonge, P.J., Franzblau, S.G., Pham, D.H., Esguerra, C.V., Crawford, A.D., Maes, L., and Tasdemir, D. (2013) Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target. Journal of natural products. 76(6):1064-1070
Bohni, N., Cordero-Maldonado, M.L., Maes, J., Siverio-Mota, D., Marcourt, L., Munck, S., Kamuhabwa, A.R., Moshi, M.J., Esguerra, C.V., de Witte, P.A., Crawford, A.D., and Wolfender, J.L. (2013) Integration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products. PLoS One. 8(5):e64006
Afrikanova, T., Serruys, A.S., Buenafe, O.E., Clinckers, R., Smolders, I., de Witte, P.A., Crawford, A.D., and Esguerra, C.V. (2013) Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs. PLoS One. 8(1):e54166
Orellana-Paucar, A.M., Serruys, A.S., Afrikanova, T., Maes, J., De Borggraeve, W., Alen, J., León-Tamariz, F., Wilches-Arizábala, I.M., Crawford, A.D., de Witte, P.A., and Esguerra, C.V. (2012) Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models. Epilepsy & behavior : E&B. 24(1):14-22
Maes, J., Verlooy, L., Buenafe, O.E., de Witte, P.A., Esguerra, C.V., and Crawford, A.D. (2012) Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae. PLoS One. 7(10):e43850
Challal, S., Bohni, N., Buenafe, O.E., Esguerra, C.V., de Witte, P.A., Wolfender, J.L., and Crawford, A.D. (2012) Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products. Chimia. 66(4):229-232
Marrero-Ponce, Y., Siverio-Mota, D., Gálvez-Llompart, M., Recio, M.C., Giner, R.M., García-Domènech, R., Torrens, F., Arán, V.J., Cordero-Maldonado, M.L., Esguera, C.V., de Witte, P.A., and Crawford, A.D. (2011) Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype. European Journal of Medicinal Chemistry. 46(12):5736-53
Vermoesen, K., Serruys, A.S., Loyens, E., Afrikanova, T., Massie, A., Schallier, A., Michotte, Y., Crawford, A.D., Esguerra, C.V., de Witte, P.A., Smolders, I., and Clinckers, R. (2011) Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models. Epilepsy & behavior : E&B. 22(3):450-60
Crawford, A.D., Liekens, S., Kamuhabwa, A.R., Maes, J., Munck, S., Busson, R., Rozenski, J., Esguerra, C.V., and de Witte, P.A. (2011) Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East african medicinal plants. PLoS One. 6(2):e14694
Walpita, C.N., Crawford, A.D., and Darras, V.M. (2010) Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio). General and comparative endocrinology. 166(1):134-141
Walpita, C.N., Crawford, A.D., Janssens, E.D., Van der Geyten, S., and Darras, V.M. (2009) Type 2 Iodothyronine Deiodinase is Essential for Thyroid Hormone-Dependent Embryonic Development and Pigmentation in Zebrafish. Endocrinology. 150(1):530-539
Crawford, A.D., Esguerra, C.V., and de Witte, P.A. (2008) Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery. Planta Medica. 74(6):624-632
Esguerra, C.V., Nelles, L., Vermeire, L., Ibrahimi, A., Crawford, A.D., Derua, R., Janssens, E., Waelkens, E., Carmeliet, P., Collen, D., and Huylebroeck, D. (2007) Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. Development (Cambridge, England). 134(24):4381-4393
Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffman, H., Meyer, S.U., Muller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development (Cambridge, England). 123:427-438
Trowe, T., Klostermann, S., Baier, H., Granato, M., Crawford, A.D., Grunewald, B., Hoffman, H., Karlstrom, R.O., Meyer, S.U., Muller, B., Richter, S., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development (Cambridge, England). 123:439-450