PUBLICATION
Fovea-like Photoreceptor Specializations Underlie Single UV Cone Driven Prey-Capture Behavior in Zebrafish
- Authors
- Yoshimatsu, T., Schröder, C., Nevala, N.E., Berens, P., Baden, T.
- ID
- ZDB-PUB-200601-4
- Date
- 2020
- Source
- Neuron 107(2): 320-337.e6 (Journal)
- Registered Authors
- Baden, Tom, Yoshimatsu, Takeshi
- Keywords
- UV vision, cone, fovea, photoreceptor, phototransduction, prey capture, retina, ribbon synapse, zebrafish
- MeSH Terms
-
- Animals
- Calcium Signaling
- Computer Simulation
- Glutamic Acid/metabolism
- Larva
- Light
- Light Signal Transduction
- Photoreceptor Cells, Vertebrate/physiology*
- Predatory Behavior/physiology*
- Retinal Cone Photoreceptor Cells/physiology*
- Retinal Horizontal Cells/physiology
- Synapses/physiology
- Transcriptome
- Ultraviolet Rays
- Visual Fields
- Zebrafish/physiology*
- PubMed
- 32473094 Full text @ Neuron
Citation
Yoshimatsu, T., Schröder, C., Nevala, N.E., Berens, P., Baden, T. (2020) Fovea-like Photoreceptor Specializations Underlie Single UV Cone Driven Prey-Capture Behavior in Zebrafish. Neuron. 107(2):320-337.e6.
Abstract
In the eye, the function of same-type photoreceptors must be regionally adjusted to process a highly asymmetrical natural visual world. Here, we show that UV cones in the larval zebrafish area temporalis are specifically tuned for UV-bright prey capture in their upper frontal visual field, which may use the signal from a single cone at a time. For this, UV-photon detection probability is regionally boosted more than 10-fold. Next, in vivo two-photon imaging, transcriptomics, and computational modeling reveal that these cones use an elevated baseline of synaptic calcium to facilitate the encoding of bright objects, which in turn results from expressional tuning of phototransduction genes. Moreover, the light-driven synaptic calcium signal is regionally slowed by interactions with horizontal cells and later accentuated at the level of glutamate release driving retinal networks. These regional differences tally with variations between peripheral and foveal cones in primates and hint at a common mechanistic origin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping