PUBLICATION
A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain
- Authors
- Yildizoglu, T., Riegler, C., Fitzgerald, J.E., Portugues, R.
- ID
- ZDB-PUB-200511-3
- Date
- 2020
- Source
- Current biology : CB 30(12): 2321-2333.e6 (Journal)
- Registered Authors
- Keywords
- arborization fields, glider stimuli, motion vision, naturalistic images, optomotor response, pretectum, wholebrain imaging, zebrafish
- MeSH Terms
-
- Animals
- Brain/physiology*
- Motion Perception/physiology*
- Retinal Ganglion Cells/physiology
- Visual Perception/physiology*
- Zebrafish/physiology*
- PubMed
- 32386533 Full text @ Curr. Biol.
Citation
Yildizoglu, T., Riegler, C., Fitzgerald, J.E., Portugues, R. (2020) A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain. Current biology : CB. 30(12):2321-2333.e6.
Abstract
All animals must transform ambiguous sensory data into successful behavior. This requires sensory representations that accurately reflect the statistics of natural stimuli and behavior. Multiple studies show that visual motion processing is tuned for accuracy under naturalistic conditions, but the sensorimotor circuits extracting these cues and implementing motion-guided behavior remain unclear. Here we show that the larval zebrafish retina extracts a diversity of naturalistic motion cues, and the retinorecipient pretectum organizes these cues around the elements of behavior. We find that higher-order motion stimuli, gliders, induce optomotor behavior matching expectations from natural scene analyses. We then image activity of retinal ganglion cell terminals and pretectal neurons. The retina exhibits direction-selective responses across glider stimuli, and anatomically clustered pretectal neurons respond with magnitudes matching behavior. Peripheral computations thus reflect natural input statistics, whereas central brain activity precisely codes information needed for behavior. This general principle could organize sensorimotor transformations across animal species.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping