PUBLICATION
Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level
- Authors
- Lin, Q., Manley, J., Helmreich, M., Schlumm, F., Li, J.M., Robson, D.N., Engert, F., Schier, A., Nöbauer, T., Vaziri, A.
- ID
- ZDB-PUB-200121-1
- Date
- 2020
- Source
- Cell 180(3): 536-551.e17 (Journal)
- Registered Authors
- Engert, Florian, Robson, Drew, Schier, Alexander
- Keywords
- Cerebellum, Light field microscopy, action selection, decision making, demixed principal component analysis, motor planning, operant learning, population ramping activity, whole-brain calcium imaging, zebrafish
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology
- Brain Mapping/methods
- Cerebellum/physiology*
- Cerebrum/physiology
- Cognition/physiology
- Conditioning, Operant/physiology
- Decision Making/physiology*
- Goals
- Habenula/physiology
- Hot Temperature
- Larva/physiology
- Motor Activity/physiology
- Movement
- Neurons/physiology
- Psychomotor Performance/physiology
- Reaction Time/physiology*
- Rhombencephalon/physiology
- Zebrafish/physiology*
- PubMed
- 31955849 Full text @ Cell
Citation
Lin, Q., Manley, J., Helmreich, M., Schlumm, F., Li, J.M., Robson, D.N., Engert, F., Schier, A., Nöbauer, T., Vaziri, A. (2020) Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level. Cell. 180(3):536-551.e17.
Abstract
Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (>10 s before movement initiation), mainly within the granule cells. Turn directions are determined by the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the trial-by-trial level. Our results highlight a cognitive role of the cerebellum and its importance in motor planning.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping