PUBLICATION
Zebrafish models: Gaining insight into purinergic signaling and neurological disorders
- Authors
- Nabinger, D.D., Altenhofen, S., Bonan, C.D.
- ID
- ZDB-PUB-191106-9
- Date
- 2019
- Source
- Progress in neuro-psychopharmacology & biological psychiatry 98: 109770 (Review)
- Registered Authors
- Bonan, Carla Denise
- Keywords
- Adenosine, Adenosine triphosphate, Ectonucleotidases, Neurological disorders, Purinergic signaling, Zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Humans
- Nervous System Diseases/genetics*
- Nervous System Diseases/physiopathology*
- Receptors, Purinergic/genetics*
- Signal Transduction*
- Zebrafish/physiology*
- PubMed
- 31678483 Full text @ Prog. Neuropsychopharmacol. Biol. Psychiatry
Citation
Nabinger, D.D., Altenhofen, S., Bonan, C.D. (2019) Zebrafish models: Gaining insight into purinergic signaling and neurological disorders. Progress in neuro-psychopharmacology & biological psychiatry. 98:109770.
Abstract
Zebrafish (Danio rerio) has been considered a complementary model for biomedical studies, especially due to advantages such as external and rapid development, and genetic manipulation. There is growing interest in this model in neuroscience research since the species has morphological and physiological similarities to mammals and a complex behavioral repertoire. The purinergic signaling has been described in zebrafish, and purinoceptors and nucleotide- and nucleoside-metabolizing enzymes have already been identified in the central nervous system (CNS) of this species. The involvement of the purinergic system in several models of neurological disorders, such as Alzheimer's disease, Parkinson's disease, epilepsy, schizophrenia, and autism has been investigated in zebrafish. This mini review presents several studies describing purinergic signaling in the zebrafish CNS and the action of this neurotransmitter system in models of neurological disorders using this species as a biological model. The use of pharmacological approaches at different stages of development may be a useful tool for preclinical assays and the testing of purinergic compounds as new alternatives for the treatment of neurological disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping