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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-001109-18
Lyons, David A.
Email: david.lyons@ed.ac.uk
URL:
Affiliation: David Lyons Lab
Address: Centre for Neuroregeneration Chancellor's Building, GU 507B 49 Little France Crescent Edinburgh, EH16 4SB United Kingdom
Country: United Kingdom
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BIOGRAPHY AND RESEARCH INTERESTS
Myelin is an essential component of the vertebrate nervous system and disruption to myelinated axons can cause the debilitating symptoms of many human diseases such as Multiple Sclerosis. My lab uses zebrafish to dissect the cellular and genetic basis of myelin formation in the Central Nervous System.


PUBLICATIONS
Yang, Z., Cole, K.L.H., Qiu, Y., Somorjai, I.M.L., Wijesinghe, P., Nylk, J., Cochran, S., Spalding, G.C., Lyons, D.A., Dholakia, K. (2019) Light sheet microscopy with acoustic sample confinement. Nature communications. 10:669
Karttunen, M.J., Lyons, D.A. (2019) A Drug-Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation. Methods in molecular biology (Clifton, N.J.). 1936:227-238
Williamson, J.M., Lyons, D.A., Almeida, R.G. (2019) Manipulating Neuronal Activity in the Developing Zebrafish Spinal Cord to Investigate Adaptive Myelination. Methods in molecular biology (Clifton, N.J.). 1936:211-225
Kegel, L., Rubio, M., Almeida, R.G., Benito, S., Klingseisen, A., Lyons, D.A. (2019) Forward Genetic Screen Using Zebrafish to Identify New Genes Involved in Myelination. Methods in molecular biology (Clifton, N.J.). 1936:185-209
Early, J.J., Cole, K.L., Williamson, J.M., Swire, M., Kamadurai, H., Muskavitch, M., Lyons, D.A. (2018) An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination. eLIFE. 7:
Almeida, R.G., Pan, S., Cole, K.L.H., Williamson, J.M., Early, J.J., Czopka, T., Klingseisen, A., Chan, J.R., Lyons, D.A. (2018) Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand. Current biology : CB. 28(8):1296-1305.e5
Baraban, M., Koudelka, S., Lyons, D.A. (2018) Ca 2+ activity signatures of myelin sheath formation and growth in vivo. Nature Neuroscience. 21:19-23
Bin, J.M., Lyons, D.A. (2016) Imaging Myelination In Vivo Using Transparent Animal Models.. Brain plasticity (Amsterdam, Netherlands). 2:3-29
Almeida, R., Lyons, D. (2016) Oligodendrocyte Development in the Absence of Their Target Axons In Vivo. PLoS One. 11:e0164432
Koudelka, S., Voas, M.G., Almeida, R.G., Baraban, M., Soetaert, J., Meyer, M.P., Talbot, W.S., Lyons, D.A. (2016) Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release. Current biology : CB. 26(11):1447-55
Almeida, R.G., Lyons, D.A. (2015) Intersectional Gene Expression in Zebrafish Using the Split KalTA4 System. Zebrafish. 12(6):377-86
Nawaz, S., Sánchez, P., Schmitt, S., Snaidero, N., Mitkovski, M., Velte, C., Brückner, B.R., Alexopoulos, I., Czopka, T., Jung, S.Y., Rhee, J.S., Janshoff, A., Witke, W., Schaap, I.A., Lyons, D.A., Simons, M. (2015) Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system. Developmental Cell. 34:139-51
Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., Lyons, D. A. (2015) Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nature Neuroscience. 18:628-630
Czopka, T., Ffrench-Constant, C., and Lyons, D.A. (2013) Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo. Developmental Cell. 25(6):599-609
Almeida, R.G., Czopka, T., Ffrench-Constant, C., and Lyons, D.A. (2011) Individual axons regulate the myelinating potential of single oligodendrocytes in vivo. Development (Cambridge, England). 138(20):4443-50
Raphael, A.R., Lyons, D.A., and Talbot, W.S. (2011) ErbB signaling has a role in radial sorting independent of Schwann cell number. Glia. 59(7):1047-1055
Czopka, T., and Lyons, D.A. (2011) Dissecting mechanisms of myelinated axon formation using zebrafish. Methods in cell biology. 105:25-62
Lyons, D.A., Naylor, S.G., Scholze, A., and Talbot, W.S. (2009) Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. Nature Genetics. 41(7):854-858
Lyons, D.A., Naylor, S.G., Mercurio, S., Dominguez, C., and Talbot, W.S. (2008) KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome. Development (Cambridge, England). 135(3):599-609
Tawk, M., Araya, C., Lyons, D.A., Reugels, A.M., Girdler, G.C., Bayley, P.R., Hyde, D.R., Tada, M., and Clarke, J.D. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature. 446(7137):797-800
Voas, M.G., Lyons, D.A., Naylor, S.G., Arana, N., Rasband, M.N., and Talbot, W.S. (2007) alphaII-Spectrin Is Essential for Assembly of the Nodes of Ranvier in Myelinated Axons. Current biology : CB. 17(6):562-568
Pogoda, H.M., Sternheim, N., Lyons, D.A., Diamond, B., Hawkins, T.A., Woods, I.G., Bhatt, D.H., Franzini-Armstrong, C., Dominguez, C., Arana, N., Jacobs, J., Nix, R., Fetcho, J.R., and Talbot, W.S. (2006) A genetic screen identifies genes essential for development of myelinated axons in zebrafish. Developmental Biology. 298(1):118-131
Woods, I.G., Lyons, D.A., Voas, M.G., Pogoda, H.M., and Talbot, W.S. (2006) nsf Is Essential for Organization of Myelinated Axons in Zebrafish. Current biology : CB. 16(7):636-648
Lyons, D.A., Pogoda, H.M., Voas, M.G., Woods, I.G., Diamond, B., Nix, R., Arana, N., Jacobs, J., and Talbot, W.S. (2005) erbb3 and erbb2 Are Essential for Schwann Cell Migration and Myelination in Zebrafish. Current biology : CB. 15(6):513-524
Rauch, G.J., Lyons, D.A., Middendorf, I., Friedlander, B., Arana, N., Reyes, T., and Talbot, W.S. (2003) Submission and Curation of Gene Expression Data. ZFIN Direct Data Submission.
Lyons, D.A., Guy, A.T., and Clarke, J.D. (2003) Monitoring neural progenitor fate through multiple rounds of division in an intact vertebrate brain. Development (Cambridge, England). 130(15):427-436
Klisa, C., Bayley, P., Lyons, D.A., Nüsslein-Volhard, C., Clarke, J.D.W., Brand, M., and Wilson, S.W. (2002) Identification and characterization of novel zebrafish brain development mutants by large-scale mutagenesis screening. Developmental Biology. 247(2):447

NON-ZEBRAFISH PUBLICATIONS