ZFIN ID: ZDB-PERS-001109-18
Lyons, David A.
Email: david.lyons@ed.ac.uk
Affiliation: David Lyons Lab
Address: Centre for Neuroregeneration Chancellor's Building, GU 507B 49 Little France Crescent Edinburgh, EH16 4SB United Kingdom
Country: United Kingdom

Myelin is an essential component of the vertebrate nervous system and disruption to myelinated axons can cause the debilitating symptoms of many human diseases such as Multiple Sclerosis. My lab uses zebrafish to dissect the cellular and genetic basis of myelin formation in the Central Nervous System.

Bin, J.M., Suminaite, D., Benito-Kwiecinski, S.K., Kegel, L., Rubio-Brotons, M., Early, J.J., Soong, D., Livesey, M.R., Poole, R.J., Lyons, D.A. (2024) Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons. Nature communications. 15:17901790
Ghosh, T., Almeida, R.G., Zhao, C., Mannioui, A., Martin, E., Fleet, A., Chen, C.Z., Assinck, P., Ellams, S., Gonzalez, G.A., Graham, S.C., Rowitch, D.H., Stott, K., Adams, I., Zalc, B., Goldman, N., Lyons, D.A., Franklin, R.J.M. (2024) A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression. Cell. 187:814830.e23814-830.e23
Vagionitis, S., Auer, F., Xiao, Y., Almeida, R.G., Lyons, D.A., Czopka, T. (2022) Clusters of neuronal neurofascin prefigure the position of a subset of nodes of Ranvier along individual central nervous system axons in vivo. Cell Reports. 38:110366
Madden, M.E., Suminaite, D., Ortiz, E., Early, J.E., Koudelka, S., Livesey, M.R., Bianco, I.H., Granato, M., Lyons, D.A. (2021) Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(44):9099-9111
Almeida, R.G., Williamson, J.M., Madden, M.E., Early, J.J., Voas, M.G., Talbot, W.S., Bianco, I.H., Lyons, D.A. (2021) Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth. Current biology : CB. 31(17):3743-3754.e5
Moyon, S., Frawley, R., Marechal, D., Huang, D., Marshall-Phelps, K.L.H., Kegel, L., Bøstrand, S.M.K., Sadowski, B., Jiang, Y.H., Lyons, D.A., Möbius, W., Casaccia, P. (2021) TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice. Nature communications. 12:3359
Campbell, J.S., Davidson, A.J., Todd, H., Rodrigues, F.S.L.M., Elliot, A.M., Early, J.J., Lyons, D.A., Feng, Y., Wood, W. (2020) PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo. Current biology : CB. 31(4):875-883.e5
Marshall-Phelps, K.L.H., Kegel, L., Baraban, M., Ruhwedel, T., Almeida, R.G., Rubio-Brotons, M., Klingseisen, A., Benito-Kwiecinski, S.K., Early, J.J., Bin, J.M., Suminaite, D., Livesey, M.R., Möbius, W., Poole, R.J., Lyons, D.A. (2020) Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b. The Journal of cell biology. 219(7)
Klingseisen, A., Ristoiu, A.M., Kegel, L., Sherman, D.L., Rubio-Brotons, M., Almeida, R.G., Koudelka, S., Benito-Kwiecinski, S.K., Poole, R.J., Brophy, P.J., Lyons, D.A. (2019) Oligodendrocyte Neurofascin Independently Regulates Both Myelin Targeting and Sheath Growth in the CNS. Developmental Cell. 51(6):730-744.e6
Swire, M., Kotelevtsev, Y., Webb, D.J., Lyons, D.A., Ffrench-Constant, C. (2019) Endothelin signalling mediates experience-dependent myelination in the CNS. eLIFE. 8:
Yang, Z., Cole, K.L.H., Qiu, Y., Somorjai, I.M.L., Wijesinghe, P., Nylk, J., Cochran, S., Spalding, G.C., Lyons, D.A., Dholakia, K. (2019) Light sheet microscopy with acoustic sample confinement. Nature communications. 10:669
Williamson, J.M., Lyons, D.A., Almeida, R.G. (2019) Manipulating Neuronal Activity in the Developing Zebrafish Spinal Cord to Investigate Adaptive Myelination. Methods in molecular biology (Clifton, N.J.). 1936:211-225
Karttunen, M.J., Lyons, D.A. (2019) A Drug-Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation. Methods in molecular biology (Clifton, N.J.). 1936:227-238
Kegel, L., Rubio, M., Almeida, R.G., Benito, S., Klingseisen, A., Lyons, D.A. (2019) Forward Genetic Screen Using Zebrafish to Identify New Genes Involved in Myelination. Methods in molecular biology (Clifton, N.J.). 1936:185-209
Early, J.J., Cole, K.L., Williamson, J.M., Swire, M., Kamadurai, H., Muskavitch, M., Lyons, D.A. (2018) An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination. eLIFE. 7:
Almeida, R.G., Pan, S., Cole, K.L.H., Williamson, J.M., Early, J.J., Czopka, T., Klingseisen, A., Chan, J.R., Lyons, D.A. (2018) Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand. Current biology : CB. 28(8):1296-1305.e5
Baraban, M., Koudelka, S., Lyons, D.A. (2018) Ca 2+ activity signatures of myelin sheath formation and growth in vivo. Nature Neuroscience. 21:19-23
Karttunen, M.J., Czopka, T., Goedhart, M., Early, J.J., Lyons, D.A. (2017) Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber. PLoS One. 12:e0178058
Bin, J.M., Lyons, D.A. (2016) Imaging Myelination In Vivo Using Transparent Animal Models.. Brain plasticity (Amsterdam, Netherlands). 2:3-29
Almeida, R., Lyons, D. (2016) Oligodendrocyte Development in the Absence of Their Target Axons In Vivo. PLoS One. 11:e0164432
Koudelka, S., Voas, M.G., Almeida, R.G., Baraban, M., Soetaert, J., Meyer, M.P., Talbot, W.S., Lyons, D.A. (2016) Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release. Current biology : CB. 26(11):1447-55
Almeida, R.G., Lyons, D.A. (2015) Intersectional Gene Expression in Zebrafish Using the Split KalTA4 System. Zebrafish. 12(6):377-86
Nawaz, S., Sánchez, P., Schmitt, S., Snaidero, N., Mitkovski, M., Velte, C., Brückner, B.R., Alexopoulos, I., Czopka, T., Jung, S.Y., Rhee, J.S., Janshoff, A., Witke, W., Schaap, I.A., Lyons, D.A., Simons, M. (2015) Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system. Developmental Cell. 34:139-51
Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., Lyons, D. A. (2015) Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nature Neuroscience. 18:628-630
Czopka, T., Ffrench-Constant, C., and Lyons, D.A. (2013) Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo. Developmental Cell. 25(6):599-609
Almeida, R.G., Czopka, T., Ffrench-Constant, C., and Lyons, D.A. (2011) Individual axons regulate the myelinating potential of single oligodendrocytes in vivo. Development (Cambridge, England). 138(20):4443-50
Raphael, A.R., Lyons, D.A., and Talbot, W.S. (2011) ErbB signaling has a role in radial sorting independent of Schwann cell number. Glia. 59(7):1047-1055
Czopka, T., and Lyons, D.A. (2011) Dissecting mechanisms of myelinated axon formation using zebrafish. Methods in cell biology. 105:25-62
Lyons, D.A., Naylor, S.G., Scholze, A., and Talbot, W.S. (2009) Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. Nature Genetics. 41(7):854-858
Lyons, D.A., Naylor, S.G., Mercurio, S., Dominguez, C., and Talbot, W.S. (2008) KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome. Development (Cambridge, England). 135(3):599-609
Tawk, M., Araya, C., Lyons, D.A., Reugels, A.M., Girdler, G.C., Bayley, P.R., Hyde, D.R., Tada, M., and Clarke, J.D. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature. 446(7137):797-800
Voas, M.G., Lyons, D.A., Naylor, S.G., Arana, N., Rasband, M.N., and Talbot, W.S. (2007) alphaII-Spectrin Is Essential for Assembly of the Nodes of Ranvier in Myelinated Axons. Current biology : CB. 17(6):562-568
Pogoda, H.M., Sternheim, N., Lyons, D.A., Diamond, B., Hawkins, T.A., Woods, I.G., Bhatt, D.H., Franzini-Armstrong, C., Dominguez, C., Arana, N., Jacobs, J., Nix, R., Fetcho, J.R., and Talbot, W.S. (2006) A genetic screen identifies genes essential for development of myelinated axons in zebrafish. Developmental Biology. 298(1):118-131
Woods, I.G., Lyons, D.A., Voas, M.G., Pogoda, H.M., and Talbot, W.S. (2006) nsf Is Essential for Organization of Myelinated Axons in Zebrafish. Current biology : CB. 16(7):636-648
Lyons, D.A., Pogoda, H.M., Voas, M.G., Woods, I.G., Diamond, B., Nix, R., Arana, N., Jacobs, J., and Talbot, W.S. (2005) erbb3 and erbb2 Are Essential for Schwann Cell Migration and Myelination in Zebrafish. Current biology : CB. 15(6):513-524
Rauch, G.J., Lyons, D.A., Middendorf, I., Friedlander, B., Arana, N., Reyes, T., and Talbot, W.S. (2003) Submission and Curation of Gene Expression Data. ZFIN Direct Data Submission.
Lyons, D.A., Guy, A.T., and Clarke, J.D. (2003) Monitoring neural progenitor fate through multiple rounds of division in an intact vertebrate brain. Development (Cambridge, England). 130(15):427-436
Klisa, C., Bayley, P., Lyons, D.A., Nüsslein-Volhard, C., Clarke, J.D.W., Brand, M., and Wilson, S.W. (2002) Identification and characterization of novel zebrafish brain development mutants by large-scale mutagenesis screening. Developmental Biology. 247(2):447