ZFIN ID: ZDB-PUB-190313-3
Spotlight on zebrafish: the next wave of translational research
Patton, E.E., Tobin, D.M.
Date: 2019
Source: Disease models & mechanisms   12(3): (Other)
Registered Authors: Patton, E. Elizabeth, Tobin, David
Keywords: Disease models, Genome editing, Zebrafish
MeSH Terms:
  • Animals
  • Disease Models, Animal
  • Drug Discovery
  • Human Genetics
  • Metabolic Diseases/genetics
  • Translational Medical Research*
  • Zebrafish/metabolism*
PubMed: 30858282 Full text @ Dis. Model. Mech.
Five years after the launch of the Disease Models & Mechanisms (DMM) Special Issue on zebrafish as a disease model, the field has progressed significantly. Zebrafish have been used to precisely model human genetic variants, to unpick the mechanisms of metabolic and other diseases, to study infection, inflammation and cancer, and to develop and test new therapeutic approaches. In this Editorial, we highlight recent research published in DMM that uses zebrafish to develop new experimental tools and to provide new insight into disease mechanism and therapy. The broad spectrum of subjects and approaches covered in these articles underscores the versatility of zebrafish in translational research. Further, it highlights the zebrafish community's ethos of creativity and collaboration in translating basic biological research into clinically relevant advances affecting how we understand and treat human disease.