PUBLICATION
Information processing in the vertebrate habenula
- Authors
- Fore, S., Palumbo, F., Pelgrims, R., Yaksi, E.
- ID
- ZDB-PUB-181212-34
- Date
- 2018
- Source
- Seminars in cell & developmental biology 78: 130-139 (Review)
- Registered Authors
- Fore, Stephanie, Palumbo, Fabrizio, Pelgrims, Robbrecht, Yaksi, Emre
- Keywords
- Addiction, Anxiety, Asymmetry, Attractor networks, Default mode network, Fear, Habenula, Interpeduncular nucleus, Learning, Mood disorders, Neural circuits, Ongoing activity, Prediction error, Raphe nucleus, Sensory activity, Sensory processing, Sensory systems, Social behavior, Spontaneous activity, Stress, Ventral tegmental area
- MeSH Terms
-
- Animals
- Behavior, Addictive/physiopathology*
- Emotions/physiology*
- Habenula/physiology*
- Humans
- Mental Disorders/physiopathology*
- Mental Processes/physiology*
- Sensation/physiology
- Zebrafish/physiology
- PubMed
- 28797836 Full text @ Sem. Cell Dev. Biol.
Citation
Fore, S., Palumbo, F., Pelgrims, R., Yaksi, E. (2018) Information processing in the vertebrate habenula. Seminars in cell & developmental biology. 78:130-139.
Abstract
The habenula is a brain region that has gained increasing popularity over the recent years due to its role in processing value-related and experience-dependent information with a strong link to depression, addiction, sleep and social interactions. This small diencephalic nucleus is proposed to act as a multimodal hub or a switchboard, where inputs from different brain regions converge. These diverse inputs to the habenula carry information about the sensory world and the animal's internal state, such as reward expectation or mood. However, it is not clear how these diverse habenular inputs interact with each other and how such interactions contribute to the function of habenular circuits in regulating behavioral responses in various tasks and contexts. In this review, we aim to discuss how information processing in habenular circuits, can contribute to specific behavioral programs that are attributed to the habenula.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
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