PUBLICATION
Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish
- Authors
- Suniaga, S., Rolvien, T., Vom Scheidt, A., Fiedler, I.A.K., Bale, H.A., Huysseune, A., Witten, P.E., Amling, M., Busse, B.
- ID
- ZDB-PUB-180228-2
- Date
- 2018
- Source
- Scientific Reports 8: 3646 (Journal)
- Registered Authors
- Huysseune, Ann, Witten, P. Eckhard
- Keywords
- none
- MeSH Terms
-
- Animals
- Bone Density/physiology
- Bone and Bones/physiology*
- Osteogenesis/physiology
- Physical Conditioning, Animal
- Swimming
- Zebrafish/physiology*
- PubMed
- 29483529 Full text @ Sci. Rep.
Citation
Suniaga, S., Rolvien, T., Vom Scheidt, A., Fiedler, I.A.K., Bale, H.A., Huysseune, A., Witten, P.E., Amling, M., Busse, B. (2018) Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish. Scientific Reports. 8:3646.
Abstract
Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age- and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, bone volume and mineralization. Clearly, modeling processes in zebrafish bone resemble processes in human bone. This study highlights how exercise experiments in adult zebrafish foster in-depth insight into aging-related bone diseases and can thus catalyze the search for appropriate prevention and new treatment options.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping