ZFIN Person: Witten, P. Eckhard

ZFIN ID: ZDB-PERS-150225-1

ZFIN ID: ZDB-PERS-150225-1

Witten, P. Eckhard

Email:	PEckhardWitten@aol.com
URL:	http://eckhardwitten.com/
Affiliation:	Research Group: Evolutionary Developmental Biology
Address:	Prof. Dr. Eckhard Witten Department of Biology Ledeganckstraat 35 B-9000 Gent Belgium
Country:
Phone:	+32 (9) 3645229
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Development, plasticity, and remodelling of skeletal tissues: bone, cartilage and teeth. Comparative developmental and evolutionary analysis at and below the cellular level. Current projects:(a) basic developmental and evolutionary processes related to tooth and vertebral column formation. (b) the prevention farmed fish from developing skeletal malformations. (c) The study human skeletal disease on zebrafish and medaka models.

Latest results, the uncoupling of bone formation and mineralisation: http://onlinelibrary.wiley.com/doi/10.1111/jfb.12870/full

IAFSB 2018
The fifth conference “Interdisciplinary Approaches in Fish Skeletal Biology” takes place in Tavira, Portugal, April 18-20, 2018.
http://iafsb.org/
Great Science at a Beautiful Location!

PUBLICATIONS

Huysseune, A., Larsen, U.G., Larionova, D., Matthiesen, C.L., Petersen, S.V., Muller, M., Witten, P.E. (2023) Bone Formation in Zebrafish: The Significance of DAF-FM DA Staining for Nitric Oxide Detection. Biomolecules. 13(12):

Martini, A., Sahd, L., Rücklin, M., Huysseune, A., Hall, B.K., Boglione, C., Witten, P.E. (2023) Deformity or variation? Phenotypic diversity in the zebrafish vertebral column. Journal of anatomy. 243(6):960-981

Tonelli, F., Leoni, L., Daponte, V., Gioia, R., Cotti, S., Fiedler, I.A.K., Larianova, D., Willaert, A., Coucke, P.J., Villani, S., Busse, B., Besio, R., Rossi, A., Witten, P.E., Forlino, A. (2023) Zebrafish Tric-b is required for skeletal development and bone cells differentiation. Frontiers in endocrinology. 14:10029141002914

Printzi, A., Mazurais, D., Witten, P.E., Madec, L., Gonzalez, A.A., Mialhe, X., Zambonino-Infante, J.L., Koumoundouros, G. (2022) Juvenile zebrafish (Danio rerio) are able to recover from lordosis. Scientific Reports. 12:2153321533

Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b^-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152

Cotti, S., Huysseune, A., Larionova, D., Koppe, W., Forlino, A., Witten, P.E. (2022) Compression Fractures and Partial Phenotype Rescue With a Low Phosphorus Diet in the Chihuahua Zebrafish Osteogenesis Imperfecta Model. Frontiers in endocrinology. 13:851879

Huysseune, A., Soenens, M., Sire, J.Y., Witten, P.E. (2022) High-Resolution Histology for Craniofacial Studies on Zebrafish and Other Teleost Models. Methods in molecular biology (Clifton, N.J.). 2403:249-262

Huysseune, A., Cerny, R., Witten, P.E. (2021) The conundrum of pharyngeal teeth origin: the role of germ layers, pouches, and gill slits. Biological reviews of the Cambridge Philosophical Society. 97(1):414-447

Rosa, J.T., Witten, P.E., Huysseune, A. (2021) Cells at the Edge: The Dentin-Bone Interface in Zebrafish Teeth. Frontiers in Physiology. 12:723210

Kague, E., Turci, F., Newman, E., Yang, Y., Brown, K.R., Aglan, M.S., Otaify, G.A., Temtamy, S.A., Ruiz-Perez, V.L., Cross, S., Royall, C.P., Witten, P.E., Hammond, C.L. (2021) 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease. Bone research. 9:39

Qu, M., Liu, Y., Zhang, Y., Wan, S., Ravi, V., Qin, G., Jiang, H., Wang, X., Zhang, H., Zhang, B., Gao, Z., Huysseune, A., Zhang, Z., Zhang, H., Chen, Z., Yu, H., Wu, Y., Tang, L., Li, C., Zhong, J., Ma, L., Wang, F., Zheng, H., Yin, J., Witten, P.E., Meyer, A., Venkatesh, B., Lin, Q. (2021) Seadragon genome analysis provides insights into its phenotype and sex determination locus. Science advances. 7(34)

Cotti, S., Huysseune, A., Koppe, W., Rücklin, M., Marone, F., Wölfel, E.M., Fiedler, I.A.K., Busse, B., Forlino, A., Witten, P.E. (2020) More Bone with Less Minerals? The Effects of Dietary Phosphorus on the Post-Cranial Skeleton in Zebrafish. International Journal of Molecular Sciences. 21(15):

Oralová, V., Rosa, J.T., Larionova, D., Witten, P.E., Huysseune, A. (2020) Multiple epithelia are required to develop teeth deep inside the pharynx. Proceedings of the National Academy of Sciences of the United States of America. 117(21):11503-11512

Bek, J.W., De Clercq, A., De Saffel, H., Soenens, M., Huysseune, A., Witten, P.E., Coucke, P., Willaert, A. (2020) Photoconvertible fluorescent proteins: A versatile tool in zebrafish skeletal imaging. Journal of Fish Biology. 98(4):1007-1017

Tonelli, F., Cotti, S., Leoni, L., Besio, R., Gioia, R., Marchese, L., Giorgetti, S., Villani, S., Gistelinck, C., Wagener, R., Kobbe, B., Larionova, D., Fiedler, I.A.K., Busse, B., Eyre, D., Rossi, A., Witten, P.E., Forlino, A. (2020) Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype. Matrix biology : journal of the International Society for Matrix Biology. 90:40-60

Printzi, A., Fragkoulis, S., Dimitriadi, A., Keklikoglou, K., Arvanitidis, C., Witten, P.E., Koumoundouros, G. (2019) Exercise induced lordosis in zebrafish Danio rerio (Hamilton, 1822). Journal of Fish Biology. 98(4):987-994

Oralová, V., Rosa, J.T., Soenens, M., Bek, J.W., Willaert, A., Witten, P.E., Huysseune, A. (2019) Beyond the whole-mount phenotype: high-resolution imaging in fluorescence-based applications on zebrafish. Biology Open. 8(5):

De Clercq, A., Perrott, M.R., Davie, P.S., Preece, M.A., Owen, M.A.G., Huysseune, A., Witten, P.E. (2018) Temperature sensitive regions of the Chinook salmon vertebral column: Vestiges and meristic variation. Journal of morphology. 279(9):1301-1311

Christou, M., Iliopoulou, M., Witten, P.E., Koumoundouros, G. (2018) Segmentation pattern of zebrafish caudal fin is affected by developmental temperature and defined by multiple fusions between segments. Journal of experimental zoology. Part B, Molecular and developmental evolution. 330(6-7):330-340

Gistelinck, C., Kwon, R.Y., Malfait, F., Symoens, S., Harris, M.P., Henke, K., Hawkins, M.B., Fisher, S., Sips, P., Guillemyn, B., Bek, J.W., Vermassen, P., De Saffel, H., Witten, P.E., Weis, M., De Paepe, A., Eyre, D.R., Willaert, A., Coucke, P.J. (2018) Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Proceedings of the National Academy of Sciences of the United States of America. 115(34):E8037-E8046

Woltmann,I., Shkil, F., De Clercq, A., Huysseune, A., and Witten, P. E. (2018) Supernumerary teeth in the pharyngeal dentition of slow‐developing zebrafish (Danio rerio, Hamilton, 1822). Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology.

Suniaga, S., Rolvien, T., Vom Scheidt, A., Fiedler, I.A.K., Bale, H.A., Huysseune, A., Witten, P.E., Amling, M., Busse, B. (2018) Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish. Scientific Reports. 8:3646

Kague, E., Witten, P.E., Soenens, M., Campos, C.L., Lubiana, T., Fisher, S., Hammond, C., Brown, K.R., Passos-Bueno, M.R., Huysseune, A. (2018) Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth. Developmental Biology. 435(2):176-184

De Clercq, A., Perrott, M.R., Davie, P.S., Preece, M.A., Huysseune, A., Witten, P.E. (2017) The external phenotype-skeleton link in post-hatch farmed Chinook salmon (Oncorhynchus tshawytscha). Journal of fish diseases. 41(3):511-527

De Clercq, A., Perrott, M.R., Davie, P.S., Preece, M.A., Wybourne, B., Ruff, N., Huysseune, A., Witten, P.E. (2017) Vertebral column regionalisation in Chinook salmon, Oncorhynchus tshawytscha. Journal of anatomy. 231(4):500-514

Tan, W.H., Witten, P.E., Winkler, C., Au, D.W.T., Huysseune, A. (2017) Telomerase Expression in Medaka ( Oryzias melastigma) Pharyngeal Teeth. Journal of dental research. 96:678-684

Yu, T., Graf, M., Renn, J., Schartl, M., Larionova, D., Huysseune, A., Witten, P.E., Winkler, C. (2017) A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka. Development (Cambridge, England). 144:265-271

Witten, P.E., Harris, M.P., Huysseune, A., Winkler, C. (2017) Small teleost fish provide new insights into human skeletal diseases. Methods in cell biology. 138:321-346

Gistelinck, C., Gioia, R., Gagliardi, A., Tonelli, F., Marchese, L., Bianchi, L., Landi, C., Bini, L., Huysseune, A., Witten, P.E., Staes, A., Gevaert, K., De Rocker, N., Menten, B., Malfait, F., Leikin, S., Carra, S., Tenni, R., Rossi, A., De Paepe, A., Coucke, P., Willaert, A., Forlino, A. (2016) Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Scientific Reports. 6:21540

Bensimon-Brito, A., Cardeira, J., Dionísio, G., Huysseune, A., Cancela, M.L., Witten, P.E. (2016) Revisiting in vivo staining with alizarin red S - a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration. BMC Developmental Biology. 16:2

Symoens, S., Barnes, A.M., Gistelinck, C., Malfait, F., Guillemyn, B., Steyaert, W., Syx, D., D'hondt, S., Biervliet, M., De Backer, J., Witten, E.P., Leikin, S., Makareeva, E., Gillessen-Kaesbach, G., Huysseune, A., Vleminckx, K., Willaert, A., De Paepe, A., Marini, J.C., Coucke, P.J. (2015) Genetic Defects in TAPT1 Disrupt Ciliogenesis and Cause a Complex Lethal Osteochondrodysplasia. American journal of human genetics. 97(4):521-34

Willems, B., Tao, S., Yu, T., Huysseune, A., Witten, P.E., Winkler, C. (2015) The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish. PLoS One. 10:e0131768

Bruneel, B., Witten, P.E. (2015) Power and challenges of using zebrafish as a model for skeletal tissue imaging. Connective tissue research. 56(2):161-73

Gabor, K.A., Goody, M.F., Mowel, W.K., Breitbach, M.E., Gratacap, R.L., Witten, P.E., Kim, C.H. (2014) Influenza a virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment. Disease models & mechanisms. 7(11):1227-37

Harris, M.P., Henke, K., Hawkins, M.B., Witten, P.E. (2014) Fish is Fish: the use of experimental model species to reveal causes of skeletal diversity in evolution and disease. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30:616-629

Bensimon-Brito, A., Cardeira, J., Cancela, L., Huysseune, A., and Witten, E. (2012) Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation. BMC Developmental Biology. 12(1):28

Bensimon-Brito, A., Cancela, M.L., Huysseune, A., and Witten, P.E. (2012) Vestiges, rudiments and fusion events: the zebrafish caudal fin endoskeleton in an evo-devo perspective. Evolution & development. 14(1):116-127

Dewit, J., Witten, P.E., and Huysseune, A. (2011) The mechanism of cartilage subdivision in the reorganization of the zebrafish pectoral fin endoskeleton. Journal of experimental zoology. Part B, Molecular and developmental evolution. 316(8):584-97

Apschner, A., Schulte-Merker, S., and Witten, P.E. (2011) Not All Bones are Created Equal - Using Zebrafish and Other Teleost Species in Osteogenesis Research. Methods in cell biology. 105:239-255

Dewit, J., Witten, P. E., Willems, M., Huysseune, A. (2010) The distribution of fibronectin in developing zebrafish (Danio rerio) cartilage. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 26(2):205-209

Bensimon-Brito, A., Cancela, M. L., Huysseune, A., Witten, P. E. (2010) The zebrafish (Danio rerio) caudal complex – a model to study vertebral body fusion. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 26(2):235-238

Witten, P.E., and Huysseune, A. (2009) A comparative view on mechanisms and functions of skeletal remodelling in teleost fish, with special emphasis on osteoclasts and their function. Biological reviews of the Cambridge Philosophical Society. 84(2):315-346

Phelan, P.E., Pressley, M.E., Witten, P.E., Mellon, M.T., Blake, S., and Kim, C.H. (2005) Characterization of Snakehead Rhabdovirus Infection in Zebrafish (Danio rerio). Journal of virology. 79(3):1842-1852

Pressley, M.E., Phelan, P.E. 3rd, Witten, P. Eckhard, Mellon, M.T., and Kim, C.H. (2005) Pathogenesis and inflammatory response to Edwardsiella tarda infection in the zebrafish. Developmental and comparative immunology. 29(6):501-513

Witten, P.E., Hansen, A., and Hall, B.K. (2001) Features of mono- and multinucleated bone resorbing cells of the zebrafish Danio rerio and their contribution to skeletal development, remodeling, and growth. Journal of morphology. 250(3):197-207

NON-ZEBRAFISH PUBLICATIONS
Witten PE, Owen MAG, Fontanillas R, Soenens M, McGurk C, Obach A (2016) Primary phosphorous-deficiency in juvenile Atlantic salmon: the uncoupling of bone formation and mineralisation. Journal of Fish Biology 88: 690-708 Open Access

Rolvien T, Nagel F, Milovanovic P, Wuertz S, Marshall PR, Jeschke A, Schmidt FN, Hahn M, Witten PE, Amling M, Busse B (2016) How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime. Proceedings of the Royal Society B – Biological Sciences, in press

Vandenplas S, Willems M, Witten PE, Hansen T, Fjelldal PG, Huysseune A (2016) Epithelial label retaining cells are absent during tooth cycling in Salmo salar and Polypterus senegalus. PloS ONE, PLOS ONE | DOI:10.1371/journal.pone.0152870 Open Access

Yu T, Witten PE, Huysseune A , Buettner A, To TT , Winkler C (2016) Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Disease Models & Mechanisms 9: 155-163 Open Access

Dean M, Ekstrom L, Ornan EM, Ballantyne J, Witten PE, Riley C, Habraken W, Omelon S (2015) Mineral homeostasis and regulation of mineralization processes in the skeletons of sharks, rays and relatives (Elasmobranchii). Seminars in Cell & Developmental Biology 46: 51-67

Seemann F, Peterson DR, Witten PE, Guo B-S, Shantanagouda AH, Ye RR, Zhang G, Au DWT (2015) Insight into the transgenerational effect of benzo[a]pyrene on bone formation in a teleost fish (Oryzias latipes).Comparative Biochemistry and Physiology. Part C, 178: 60-67

To TT, Witten PE, Huysseune A, Winkler C (2015) An adult osteopetrosis model in medaka reveals importance of osteoclast function for bone remodeling in teleost fish. Comparative Biochemistry and Physiology, Part C, 178: 68-75

Witten PE, Hall BK (2015) Teleost Skeletal Plasticity: Modulation, Adaptation, and Remodelling. Copeia, in press

Witten PE, Sire J-Y, Huysseune A (2014) Old, new and new-old concepts about the evolution of teeth. J Appl Ichthyol 30(4):636-642

Loizides M, Georgiou AN, Somarakis S, Witten PE, Koumoundouros G (2014) A new type of lordosis and vertebral body compression in Gilthead seabream (Sparus aurata Linnaeus, 1758): Aetiology, anatomy and consequences for survival. Journal of Fish Diseases 37:949–957

Poirier Stewart N, Deschamps MH, Witten PE, Le Luyer J, Proulx E, Huysseune A, Bureau DP, Vandenberg GW (2014) X-ray-based morphometrics: an approach to diagnose vertebral abnormalities in under-mineralized vertebrae of juvenile triploid all-female rainbow trout (Oncorhynchus mykiss) fed with a phosphorus deficient diet. J Appl Ichthyol 30(4):496-803

Witten PE, Hall BK, Sire J-Y, Huysseune A, Gisbert E, Rosenthal H, Laize V, Winkler C (eds.) (2014) Proceedings of the Third International Conference: Interdisciplinary Approaches in Fish Skeletal Biology. April 22–24, 2013 Tavira, Algarve, Portugal. J Appl Ichthyol 30(4):597-840

Boglione C, Gavaia P, Koumoundouros G, Gisbert E, Moren M, Fontagné S, Witten PE (2013) A review on skeletal anomalies in reared european fish larvae and juveniles. Part 1: normal and anomalous skeletogenic processes. Reviews in Aquaculture 5 (Suppl. 1): S99–S1 20 (Part 2 see: S121–S 167)

Izquierdo MS, Scolamacchia M, Betancor M, Roo J, Caballero MJ, Terova G, Witten PE (2012) Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. British Journal of Nutrition 109(10):1796-1805

To TT, Witten PE, Renn J, Bhattacharya D, Huysseune A, Winkler C (2012) Rankl induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model. Development 139:141-150

Willems B, Buettner A, Huysseune A, Renn J, Witten PE, Winkler C (2012) Conditional ablation of osteoblasts in medaka. Developmental Biology 364:128-137

Gil-Martens L, Fjelldal PG, Lock EJ, Wargelius A, Wergeland H, Witten PE, Hansen, T Waagbø R, Ørnsrud R (2012) Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) post-smolts. Aquaculture Nutrition 18(1):12-20

Witten PE, Sire J-Y, Gitelman I, Mabee PM, Rosenthal H, Laize V, Darias MJ, Winkler C (eds.) (2012) Proceedings of the Secound International Conference: Interdisciplinary Approaches in Fish Skeletal Biology. April 26–28, 2011 Tavira, Algarve, Portugal. J Appl Ichthyol 28(3): 297-488

Pais de Azevedo T, Witten PE, Huysseune A, Bensimon-Brito A, Winkler C, To TT, Palmeirim I (2012) Interrelationship and modularity of notochord and somites: A comparative view on zebrafish and chicken vertebral body development. J. Appl. Ichthyol. 28(3): 316-319

Fjelldal PG, Hansen T, Breck O, Ørnsrud R, Lock EJ, Waagbø R, Wargelius A, Witten PE (2012) Vertebral deformities in farmed Atlantic salmon (Salmo salar L.) – etiology and pathology. J. Appl. Ichthyol. 28(3):433-440

Ytteborg E, Vegusdal A, Witten PE, Berge G, Takle H, Østbye TK, Ruyter B (2010) Atlantic salmon precursor cells from white muscle differentiate into osteoblasts in vitro: Polyunsaturated fatty acids and temperature influence gene expression and PGE2 production. Biochimica et Biophysica Acta 1801:127–137

Witten PE, Huysseune A (2010) The unobtrusive majority: Mononucleated bone resorbing cells in teleost fish and mammals. J Appl Ichthyol 26(2):225-229

Huysseune A, Sire JY, Witten PE (2010) A revised hypothesis on the evolutionary origin of the vertebrate dentition. J Appl Ichthyol 26(2):152–155

Witten PE, Huysseune A, Hall BK (2010) A practical approach for the identification of the many cartilaginous tissues in teleost fish. J Appl Ichthyol 26(2):257–262

Witten PE, Huysseune A (2009) A comparative view on mechanisms and functions of skeletal remodelling in teleost fish, with special emphasis on osteoclasts and their function. Biological Reviews, 84:315-346

Witten PE, Gil-Martens L, Huysseune A, Takle H, Hjelde K (2009) Towards a classification and an understanding of developmental relationships of vertebral body malformations in Atlantic salmon (Salmo salar L.). Aquaculture, 295:6-14

Berge GM, Witten PE, Baeverfjord G, Vegusdal A, Wadsworth S, Ruyter B (2009) Diets with different n-6/n-3 fatty acid ratio in diets for juvenile Atlantic salmon, effects on growth, body composition, bone development and eicosanoid production. Aquaculture, 296:299-308

Huysseune A, Sire JY, Witten PE (2009) Evolutionary and developmental origins of the vertebrate dentition. Journal of Anatomy, 214:465-467

Huysseune A, Takle H, Soenens M, Taerwe K, Witten PE (2008) Unique and shared gene expression patterns in Atlantic salmon (Salmo salar) tooth development. Development Genes and Evolution 218:427-437

Huysseune A, Witten PE (2008) An evolutionary view on tooth development and replacement in wild Atlantic salmon (Salmo salar L.). Evolution and Development 10(1):6-14

Huysseune A, Hall BK, Witten PE (2007) Establishment, maintenance and modifications of the lower jaw dentition of wild Atlantic salmon (Salmo salar L.) throughout its life cycle. Journal Anatomy 211:471–484

Hall BK, Witten PE (2007) The Origin and Plasticity of Skeletal Tissues in Vertebrate Evolution and Development. In: Anderson JS, Sues H-D (eds), Major Transitions in Vertebrate Evolution. Indiana University Press, Bloomington, IN. 432 pages

Witten PE, Huysseune A (2007) Mechanisms of Chondrogenesis and Osteogenesis in Fins. In: Hall BK (ed.) Fins into Limbs: Evolution, Development, and Transformation. The University of Chicago Press, Chicago:79-92

Huysseune A, Witten PE (2006) Patterning of development in continuously replacing osteichthyan dentitions. Journal of Experimental Zoology (Mol Dev Evol) 306B (3):204-215

Helland S, Denstadli V, Witten P. E., Hjelde K, Storebakken T, Baeverfjord G (2006) Occurrence of hyper dense vertebrae in Atlantic salmon (Salmo salar L.) fed diets with graded levels of phytic acid. Aquaculture 261:603-614

Witten PE, Obach A, Huysseune A , Baeverfjord G (2006) Vertebrae fusion in Atlantic salmon (Salmo salar): Development, aggravation and pathways of containment. Aquaculture 258:164-172

Gil-Martens L, Witten PE, Fivelstad S, Huysseune A, Sævareid B, Obach A (2006) Impact of high water carbon dioxide levels on Atlantic salmon smolts (Salmo salar L.): Effects on bone and fish performance. Aquaculture 261 (1):80-88

Gillis JA, Witten PE, Hall BK (2006) Chondroid Bone and secondary cartilage contribute to apical dentary growth in juvenile Atlantic salmon, Salmo salar Linnaeus (1758). Journal of Fish Biology 68:1-11

Franz-Odendaal T, Hall BK, Witten PE (2006) Buried alive: how osteoblasts become osteocytes? Developmental Dynamics 235:176–190

Witten PE, Gil-Martens L, Hall BK, Huysseune A, Obach A (2005) Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny. Diseases of Aquatic Organisms 64:237-246

Legere JKD, Handrigan G, Budney L, Cole AG, Fedak T, Franz-Odendaal T, Vickaryous M, Witten PE, Hall BK (2005) Something Old, Something New: Inferring Developmental Mode from the Fossil Record. The Palaeontology Newsletter 58:26-31

Witten PE, Hall BK, Huysseune A (2005) Are breeding teeth in Atlantic salmon a component of the drastic alterations of the oral facial skeleton? Archives of oral Biology 50:213-217

Lewis LM, Lall, SP. Witten PE (2004) Morphological descriptions of the early stages of spine and vertebral development in hatchery-reared larval and juvenile Atlantic halibut (Hippoglossus hippoglossus). Aquaculture 241:47-59

Roy PK, Witten PE, Hall BK, Lall SP (2004) Effects of dietary phosphorus on bone growth and mineralisation of vertebrae in haddock (Melanogrammus aeglefinus L.). Fish Physiology & Biochemistry 2002/27:35-48

Witten PE, Hall BK (2003) Seasonal changes in the lower jaw skeleton in male Atlantic salmon (Salmo salar L.): remodelling and regression of the kype after spawning. Journal of Anatomy 203:435-450

Witten PE, Hall BK (2002) Differentiation and growth of kype skeletal tissues in anadromous male Atlantic Salmon (Salmo salar). International Journal of Developmental Biology 46:719-730

Witten PE, Hansen A, Hall BK (2001) Features of mono and multinucleated bone resorbing cells of the zebrafish Danio rerio and their contribution to skeletal development, remodeling and growth. Journal of Morphology 250:197-207

Witten PE, Villwock W, Peters N, Hall BK (2000) Resorption and bone remodeling in juvenile carp (Cyprinus carpio). Journal of Applied Ichthyology 16:254-261

Witten PE, Holliday LS, Delling G, Hall BK (1999) Immunohistochemical identification of a vacuolar proton pump (V-ATPase) in bone-resorbing cells of an advanced teleost species (Oreochromis niloticus, Teleostei, Cichlidae). Journal of Fish Biology 55:1258-1272

Witten PE (1997) Enzyme histochemical characteristics of osteoblasts and mononucleated osteoclasts in a teleost fish with acellular bone (Oreochromis niloticus, Cichlidae). Cell and Tissue Research 287:591-599

Witten PE, Villwock W (1997) Growth requires bone resorption at particular skeletal elements in a teleost fish with acellular bone (Oreochromis niloticus, Teleostei: Cichlidae). Journal of Applied Ichthyology 13 (4):149-158