ZFIN ID: ZDB-PUB-171224-1
Generic wound signals initiate regeneration in missing-tissue contexts
Owlarn, S., Klenner, F., Schmidt, D., Rabert, F., Tomasso, A., Reuter, H., Mulaw, M.A., Moritz, S., Gentile, L., Weidinger, G., Bartscherer, K.
Date: 2017
Source: Nature communications   8: 2282 (Journal)
Registered Authors: Weidinger, Gilbert
Keywords: none
MeSH Terms:
  • Animal Fins/physiology
  • Animals
  • Head/physiology
  • MAP Kinase Signaling System/genetics*
  • Planarians/genetics*
  • Planarians/physiology
  • Regeneration/genetics*
  • Regeneration/physiology
  • Signal Transduction
  • Wnt Signaling Pathway/genetics*
  • Wound Healing/genetics*
  • Wound Healing/physiology
  • Wounds and Injuries
  • Zebrafish/genetics*
  • Zebrafish/physiology
PubMed: 29273738 Full text @ Nat. Commun.
Despite the identification of numerous regulators of regeneration in different animal models, a fundamental question remains: why do some wounds trigger the full regeneration of lost body parts, whereas others resolve by mere healing? By selectively inhibiting regeneration initiation, but not the formation of a wound epidermis, here we create headless planarians and finless zebrafish. Strikingly, in both missing-tissue contexts, injuries that normally do not trigger regeneration activate complete restoration of heads and fin rays. Our results demonstrate that generic wound signals have regeneration-inducing power. However, they are interpreted as regeneration triggers only in a permissive tissue context: when body parts are missing, or when tissue-resident polarity signals, such as Wnt activity in planarians, are modified. Hence, the ability to decode generic wound-induced signals as regeneration-initiating cues may be the crucial difference that distinguishes animals that regenerate from those that cannot.