PUBLICATION

Epithelial cell behaviours during neurosensory organ formation

Authors
Kapsimali, M.
ID
ZDB-PUB-170601-6
Date
2017
Source
Development (Cambridge, England)   144: 1926-1936 (Review)
Registered Authors
Kapsimali, Marika
Keywords
Hair follicle placode, Lateral line primordium, Lung neuroendocrine cell body, Molar tooth placode, Slithering, Taste bud
MeSH Terms
  • Animals
  • Cell Differentiation
  • Cell Movement
  • Epithelial Cells/cytology*
  • Humans
  • Organogenesis*
  • Sense Organs/cytology*
  • Sense Organs/embryology*
  • Sensory Receptor Cells/cytology*
PubMed
28559238 Full text @ Development
Abstract
Perception of the environment in vertebrates relies on a variety of neurosensory mini-organs. These organs develop via a multi-step process that includes placode induction, cell differentiation, patterning and innervation. Ultimately, cells derived from one or more different tissues assemble to form a specific mini-organ that exhibits a particular structure and function. The initial building blocks of these organs are epithelial cells that undergo rearrangements and interact with neighbouring tissues, such as neural crest-derived mesenchymal cells and sensory neurons, to construct a functional sensory organ. In recent years, advances in in vivo imaging methods have allowed direct observation of these epithelial cells, showing that they can be displaced within the epithelium itself via several modes. This Review focuses on the diversity of epithelial cell behaviours that are involved in the formation of small neurosensory organs, using the examples of dental placodes, hair follicles, taste buds, lung neuroendocrine cells and zebrafish lateral line neuromasts to highlight both well-established and newly described modes of epithelial cell motility.
Genes / Markers
Figures
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Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping