ZFIN ID: ZDB-PERS-020220-1
Kapsimali, Marika
Email: marika.kapsimali@ens.fr
URL: http://www.ibens.ens.fr/spip.php?article211
Affiliation: Kapsimali Lab
Address: 46, rue d’Ulm, Paris 75005, France
Country: United Kingdom
Phone: 00 33 1 44 32 3983
Fax: 00 33 1 44 32 3988

Taste buds are the taste sensory organs located in the oropharynx of jawed vertebrates. Our work focuses on the formation of the taste sensory organ circuit. We use zebrafish, as taste buds are easily accessible in vivo in this model. We have identified Fgf, Notch and miR-200 as key players in the differentiation process of taste bud cells (Development 2011). We have also revealed that forming taste bud cells show diverse motility profiles within the epithelium,being displaced in a random, confined or directed mode (Development 2016). The latter behaviour is reminiscent of slithering observed in mouse lung neuroendocrine cells (Kuo & Krasnow 2015).

Our current work focuses on understanding the functional mechanisms underlying the formation of the circuit. We intend to examine how it becomes disrupted in pathological conditions and how the organs regenerate. The study of these rather simple, small sensory organs may also contribute in understanding how larger neuronal circuits are formed.

Kapsimali, M. (2017) Epithelial cell behaviours during neurosensory organ formation. Development (Cambridge, England). 144:1926-1936
Beretta, C.A., Dross, N., Guglielmi, L., Bankhead, P., Soulika, M., Gutierrez-Triana, J.A., Paolini, A., Poggi, L., Falk, J., Ryu, S., Kapsimali, M., Engel, U., Carl, M. (2017) Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Current biology : CB. 27(2):270–278
Tornini, V.A., Puliafito, A., Slota, L.A., Thompson, J.D., Nachtrab, G., Kaushik, A.L., Kapsimali, M., Primo, L., Di Talia, S., Poss, K.D. (2016) Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. Current biology : CB. 26(22):2981-2991
Soulika, M., Kaushik, A., Mathieu, B., Lourenço, R., Komisarczuk, A.Z., Romano, S.A., Jouary, A., Lardennois, A., Tissot, N., Okada, S., Abe, K., Becker, T.S., Kapsimali, M. (2016) Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs. Development (Cambridge, England). 143(11):2012-24
Kapsimali, M., and Barlow, L.A. (2013) Developing a sense of taste. Seminars in cell & developmental biology. 24(3):200-209
Kapsimali, M., Kaushik, A.L., Gibon, G., Dirian, L., Ernest, S., and Rosa, F.M. (2011) Fgf signaling controls pharyngeal taste bud formation through miR-200 and Delta-Notch activity. Development (Cambridge, England). 138(16):3473-3484
Komisarczuk, A.Z., Topp, S., Stigloher, C., Kapsimali, M., Bally-Cuif, L., and Becker, T.S. (2008) Enhancer detection and developmental expression of zebrafish sprouty1, a member of the fgf8 synexpression group. Developmental dynamics : an official publication of the American Association of Anatomists. 237(9):2594-2603
Kapsimali, M., Kloosterman, W.P., de Bruijn, E., Rosa, F., Plasterk, R.H., and Wilson, S.W. (2007) MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome biology. 8(8):R173
Kapsimali, M., Caneparo, L., Houart, C., and Wilson, S.W. (2004) Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity. Development (Cambridge, England). 131(23):5923-5933
Costagli, A., Kapsimali, M., Wilson, S.W., and Mione, M. (2002) Conserved and divergent patterns of Reelin expression in the zebrafish central nervous system. The Journal of comparative neurology. 450(1):73-93