ZFIN ID: ZDB-PUB-161203-17
The Zebrafish Model Organism Database: new support for human disease models, mutation details, gene expression phenotypes and searching
Howe, D.G., Bradford, Y.M., Eagle, A., Fashena, D., Frazer, K., Kalita, P., Mani, P., Martin, R., Moxon, S.T., Paddock, H., Pich, C., Ramachandran, S., Ruzicka, L., Schaper, K., Shao, X., Singer, A., Toro, S., Van Slyke, C., Westerfield, M.
Date: 2016
Source: Nucleic acids research 45(D1): D758-D768 (Journal)
Registered Authors: Bradford, Yvonne, Eagle, Anne, Fashena, David, Frazer, K., Howe, Doug, Kalita, Patrick, Mani, Prita, Martin, Ryan, Moxon, Sierra (fka Taylor), Paddock, Holly, Pich, Christian, Ramachandran, Sridhar, Ruzicka, Leyla, Schaper, Kevin, Shao, Xiang, Singer, Amy, Toro, Sabrina, Van Slyke, Ceri, Westerfield, Monte
Keywords: phenotype, gene expression, mutation, genes, zebrafish, disease model
MeSH Terms: Animals; Computational Biology/methods; Data Curation; Databases, Genetic*; Disease Models, Animal (all 15) expand
PubMed: 27899582 Full text @ Nucleic Acids Res.
ABSTRACT
The Zebrafish Model Organism Database (ZFIN; http://zfin.org) is the central resource for zebrafish (Danio rerio) genetic, genomic, phenotypic and developmental data. ZFIN curators provide expert manual curation and integration of comprehensive data involving zebrafish genes, mutants, transgenic constructs and lines, phenotypes, genotypes, gene expressions, morpholinos, TALENs, CRISPRs, antibodies, anatomical structures, models of human disease and publications. We integrate curated, directly submitted, and collaboratively generated data, making these available to zebrafish research community. Among the vertebrate model organisms, zebrafish are superbly suited for rapid generation of sequence-targeted mutant lines, characterization of phenotypes including gene expression patterns, and generation of human disease models. The recent rapid adoption of zebrafish as human disease models is making management of these data particularly important to both the research and clinical communities. Here, we describe recent enhancements to ZFIN including use of the zebrafish experimental conditions ontology, 'Fish' records in the ZFIN database, support for gene expression phenotypes, models of human disease, mutation details at the DNA, RNA and protein levels, and updates to the ZFIN single box search.
ADDITIONAL INFORMATIONNo data available