Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-676
Westerfield, Monte
Email: monte@uoneuro.uoregon.edu
URL: http://www.neuro.uoregon.edu/westerf/lab.html
Affiliation: Westerfield Lab
and also: ZFIN Database Team
Zebrafish International Resource Center (ZIRC)
Address: Institute of Neuroscience 1254 University of Oregon Eugene, OR 97403-1254 USA
Phone: (541) 346-4607
Fax: (541) 346-4548
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
A.B., Princeton University
Ph.D., Duke University

Research Interests:

Our laboratory focuses on understanding the mechanisms that regulate the differentiation of neurons. We study how the specific properties of different kinds of neurons are regulated.

We use zebrafish and a combination of anatomical, physiological, molecular, and genetic techniques. The goal of our research is to provide a better understanding of the mechanisms that regulate the establishment of specific neuronal cell fates during normal development and what goes wrong during disease.

Current projects include understanding the molecular genetics of ear and eye and development, especially as models of human disease. In particular, we are making and studying models of human Usher syndrome, the leading cause of deafblindness.


PUBLICATIONS
Blanco, B., Clément, A., Fierro, J., Washbourne, P., Westerfield, M. (2014) Complexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis Dis. Model. Mech.7:547-59.
Van Slyke, C.E., Bradford, Y.M., Westerfield, M., Haendel, M.A. (2014) The zebrafish anatomy and stage ontologies: representing the anatomy and development of Danio rerio J Biomed Semantics5:12.
Köhler, S., Doelken, S.C., Mungall, C.J., Bauer, S., Firth, H.V., Bailleul-Forestier, I., Black, G.C., Brown, D.L., Brudno, M., Campbell, J., Fitzpatrick, D.R., Eppig, J.T., Jackson, A.P., Freson, K., Girdea, M., Helbig, I., Hurst, J.A., Jähn, J., Jackson, L.G., Kelly, A.M., Ledbetter, D.H., Mansour, S., Martin, C.L., Moss, C., Mumford, A., Ouwehand, W.H., Park, S.M., Riggs, E.R., Scott, R.H., Sisodiya, S., Vooren, S.V., Wapner, R.J., Wilkie, A.O., Wright, C.F., Vulto-van Silfhout, A.T., Leeuw, N.D., de Vries, B.B., Washingthon, N.L., Smith, C.L., Westerfield, M., Schofield, P., Ruef, B.J., Gkoutos, G.V., Haendel, M., Smedley, D., Lewis, S.E., and Robinson, P.N. (2013) The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data Nucleic Acids Res.42(1):D966-74.
Phillips, J.B., Västinsalo, H., Wegner, J., Clément, A., Sankila, E.M., and Westerfield, M. (2013) The cone-dominant retina and the inner ear of zebrafish express the ortholog of CLRN1, the causative gene of human Usher syndrome type 3A Gene Expr. Patterns13(8):473-81.
Sullivan, J., Karra, K., Moxon, S.A.T., Vallejos, A., Motenko, H., Wong, J.D., Aleksic, J., Balakrishnan, R., Binkley, G., Harris, T., Hitz, B., Jayaraman, P., Lyne, R., Neuhauser, S., Pich, C., Smith, R.N., Trinh, Q., Cherry, J.M., Richardson, J., Stein, L., Twigger, S., Westerfield, M., Worthey, E., and Micklem, G. (2013) InterMOD: integrated data and tools for the unification of model organism research Sci. Rep.3:1802.
Howe, K., Clark, M.D., Torroja, C.F., Torrance, J., Berthelot, C., Muffato, M., Collins, J.E., Humphray, S., McLaren, K., Matthews, L., McLaren, S., Sealy, I., Caccamo, M., Churcher, C., Scott, C., Barrett, J.C., Koch, R., Rauch, G.J., White, S., Chow, W., Kilian, B., Quintais, L.T., Guerra-Assunção, J.A., Zhou, Y., Gu, Y., Yen, J., Vogel, J.H., Eyre, T., Redmond, S., Banerjee, R., Chi, J., Fu, B., Langley, E., Maguire, S.F., Laird, G.K., Lloyd, D., Kenyon, E., Donaldson, S., Sehra, H., Almeida-King, J., Loveland, J., Trevanion, S., Jones, M., Quail, M., Willey, D., Hunt, A., Burton, J., Sims, S., McLay, K., Plumb, B., Davis, J., Clee, C., Oliver, K., Clark, R., Riddle, C., Eliott, D., Threadgold, G., Harden, G., Ware, D., Mortimer, B., Kerry, G., Heath, P., Phillimore, B., Tracey, A., Corby, N., Dunn, M., Johnson, C., Wood, J., Clark, S., Pelan, S., Griffiths, G., Smith, M., Glithero, R., Howden, P., Barker, N., Stevens, C., Harley, J., Holt, K., Panagiotidis, G., Lovell, J., Beasley, H., Henderson, C., Gordon, D., Auger, K., Wright, D., Collins, J., Raisen, C., Dyer, L., Leung, K., Robertson, L., Ambridge, K., Leongamornlert, D., McGuire, S., Gilderthorp, R., Griffiths, C., Manthravadi, D., Nichol, S., Barker, G., Whitehead, S., Kay, M., Brown, J., Murnane, C., Gray, E., Humphries, M., Sycamore, N., Barker, D., Saunders, D., Wallis, J., Babbage, A., Hammond, S., Mashreghi-Mohammadi, M., Barr, L., Martin, S., Wray, P., Ellington, A., Matthews, N., Ellwood, M., Woodmansey, R., Clark, G., Cooper, J., Tromans, A., Grafham, D., Skuce, C., Pandian, R., Andrews, R., Harrison, E., Kimberley, A., Garnett, J., Fosker, N., Hall, R., Garner, P., Kelly, D., Bird, C., Palmer, S., Gehring, I., Berger, A., Dooley, C.M., Ersan-Ürün, Z., Eser, C., Geiger, H., Geisler, M., Karotki, L., Kirn, A., Konantz, J., Konantz, M., Oberländer, M., Rudolph-Geiger, S., Teucke, M., Osoegawa, K., Zhu, B., Rapp, A., Widaa, S., Langford, C., Yang, F., Carter, N.P., Harrow, J., Ning, Z., Herrero, J., Searle, S.M., Enright, A., Geisler, R., Plasterk, R.H., Lee, C., Westerfield, M., de Jong, P.J., Zon, L.I., Postlethwait, J.H., Nüsslein-Volhard, C., Hubbard, T.J., Crollius, H.R., Rogers, J., and Stemple, D.L. (2013) The zebrafish reference genome sequence and its relationship to the human genome Nature496:498-503.
Doelken, S.C., Köhler, S., Mungall, C.J., Gkoutos, G.V., Ruef, B.J., Smith, C., Smedley, D., Bauer, S., Klopocki, E., Schofield, P.N., Westerfield, M., Robinson, P.N., and Lewis, S.E. (2013) Phenotypic overlap in the contribution of individual genes to CNV pathogenicity Dis. Model. Mech.6(2):358-372.
Köhler, S., Doelken, S.C., Ruef, B.J., Bauer, S., Washington, N., Westerfield, M., Gkoutos, G., Schofield, P., Smedley, D., Lewis, S.E., Robinson, P.N., and Mungall, C.J. (2013) Construction and accessibility of a cross-species phenotype ontology along with gene annotations for biomedical research F1000 Res.2:30.
Howe, D.G., Bradford, Y.M., Conlin, T., Eagle, A.E., Fashena, D., Frazer, K., Knight, J., Mani, P., Martin, R., Moxon, S.A., Paddock, H., Pich, C., Ramachandran, S., Ruef, B.J., Ruzicka, L., Schaper, K., Shao, X., Singer, A., Sprunger, B., Van Slyke, C.E., and Westerfield, M. (2013) ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics Nucleic Acids Res.41(D1):D854-860.
Dahdul, W.M., Balhoff, J.P., Blackburn, D.C., Diehl, A.D., Haendel, M.A., Hall, B.K., Lapp, H., Lundberg, J.G., Mungall, C.J., Ringwald, M., Segerdell, E., Van Slyke, C.E., Vickaryous, M.K., Westerfield, M., and Mabee, P.M. (2012) A unified anatomy ontology of the vertebrate skeletal system PLoS One7(12):e51070.
Mabee, B.P., Balhoff, J.P., Dahdul, W.M., Lapp, H., Midford, P.E., Vision, T.J., and Westerfield, M. (2012) 500,000 fish phenotypes: The new informatics landscape for evolutionary and developmental biology of the vertebrate skeleton J. Appl. Ichthyol.28(3):300-305.
Gao, J., Zhang, C., Yang, B., Sun, L., Zhang, C., Westerfield, M., and Peng, G. (2012) Dcc Regulates Asymmetric Outgrowth of Forebrain Neurons in Zebrafish PLoS One7(5):e36516.
Phillips, J.B., Blanco-Sanchez, B., Lentz, J.J., Tallafuss, A., Khanobdee, K., Sampath, S., Jacobs, Z.G., Han, P.F., Mishra, M., Williams, D.S., Keats, B.J., Washbourne, P., and Westerfield, M. (2011) Harmonin (Ush1c) is required in zebrafish Muller glial cells for photoreceptor synaptic development and function Dis. Model. Mech.4(6):786-800.
Bradford, Y., Conlin, T., Dunn, N., Fashena, D., Frazer, K., Howe, D.G., Knight, J., Mani, P., Martin, R., Moxon, S.A., Paddock, H., Pich, C., Ramachandran, S., Ruef, B.J., Ruzicka, L., Bauer Schaper, H., Schaper, K., Shao, X., Singer, A., Sprague, J., Sprunger, B., Van Slyke, C., and Westerfield, M. (2011) ZFIN: enhancements and updates to the zebrafish model organism database Nucleic Acids Res.39(suppl 1):D822-D829.
Howe, D.G., Frazer, K., Fashena, D., Ruzicka, L., Bradford, Y., Ramachandran, S., Ruef, B.J., Van Slyke, C., Singer, A., and Westerfield, M. (2011) Data extraction, transformation, and dissemination through ZFIN Meth. Cell. Biol.104:311-325.
Murray, K.N., Bauer, J., Tallen, A., Matthews, J.L., Westerfield, M., and Varga, Z.M. (2011) Characterization and management of asymptomatic mycobacterium infections at the zebrafish international resource center J. Am. Assoc. Lab. Anim. Sci.50(5):675-679.
Murray, K.N., Dreska, M., Nasiadka, A., Rinne, M., Matthews, J.L., Carmichael, C., Bauer, J., Varga, Z.M., and Westerfield, M. (2011) Transmission, Diagnosis, and Recommendations for Control of Pseudoloma neurophilia Infections in Laboratory Zebrafish (Danio rerio) Facilities Comp. Med.61(4):322-329.
Detrich, H.W., Westerfield, M., Zon, L.I. (2010) The Zebrafish: Cellular and Developmental Biology, Part A Meth. Cell. Biol.100:1-347.
Delaurier, A., Eames, B.F., Blanco-Sánchez, B., Peng, G., He, X., Swartz, M.E., Ullmann, B., Westerfield, M., and Kimmel, C.B. (2010) Zebrafish sp7:EGFP: A transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration Genesis48(8):505-511.
Dahdul, W.M., Lundberg, J.G., Midford, P.E., Balhoff, J.P., Lapp, H., Vision, T.J., Haendel, M.A., Westerfield, M., and Mabee, P.M. (2010) The teleost anatomy ontology: anatomical representation for the genomics age Syst. Biol.59(4):369-383.
Ebermann, I., Phillips, J.B., Liebau, M.C., Koenekoop, R.K., Schermer, B., Lopez, I., Schäfer, E., Roux, A.F., Dafinger, C., Bernd, A., Zrenner, E., Claustres, M., Blanco, B., Nürnberg, G., Nürnberg, P., Ruland, R., Westerfield, M., Benzing, T., and Bolz, H.J. (2010) PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome J. Clin. Invest.120(6):1812-1823.
Dahdul, W.M., Balhoff, J.P., Engeman, J., Grande, T., Hilton, E.J., Kothari, C., Lapp, H., Lundberg, J.G., Midford, P.E., Vision, T.J., Westerfield, M., and Mabee, P.M. (2010) Evolutionary characters, phenotypes and ontologies: curating data from the systematic biology literature PLoS One5(5):e10708.
Ramsay, J.M., Feist, G.W., Varga, Z.M., Westerfield, M., Kent, M.L., and Schreck, C.B. (2009) Whole-body cortisol response of zebrafish to acute net handling stress Aquaculture297(1-4):157-162.
Washington, N.L., Haendel, M.A., Mungall, C.J., Ashburner, M., Westerfield, M., and Lewis, S.E. (2009) Linking Human Diseases to Animal Models Using Ontology-Based Phenotype Annotation PLoS Biol.7(11):e1000247.
Viktorin, G., Chiuchitu, C., Rissler, M., Varga, Z.M., and Westerfield, M. (2009) Emx3 is required for the differentiation of dorsal telencephalic neurons Dev. Dyn.238(8):1984-1998.
Toro, S., Wegner, J., Muller, M., Westerfield, M., and Varga, Z.M. (2009) Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis Gene Expr. Patterns9(4):200-208.
Ochi, H., and Westerfield, M. (2009) Lbx2 regulates formation of myofibrils BMC Dev. Biol.9:13.
Carmichael, C., Westerfield, M., and Varga, Z.M. (2009) Cryopreservation and in vitro fertilization at the zebrafish international resource center Meth. Mol. Biol.546:45-65.
Dutta, S., Dietrich, J.E., Westerfield, M., and Varga, Z.M. (2008) Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary Dev. Biol.319(2):248-257.
Rotllant, J., Liu, D., Yan, Y.L., Postlethwait, J.H., Westerfield, M., and Du, S.J. (2008) Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear Matrix Biol.27(6):561-572.
Ochi, H., Hans, S., and Westerfield, M. (2008) Smarcd3 regulates the timing of zebrafish myogenesis onset J. Biol. Chem.283(6):3529-3536.
Sprague, J., Bayraktaroglu, L., Bradford, Y., Conlin, T., Dunn, N., Fashena, D., Frazer, K., Haendel, M., Howe, D.G., Knight, J., Mani, P., Moxon, S.A., Pich, C., Ramachandran, S., Schaper, K., Segerdell, E., Shao, X., Singer, A., Song, P., Sprunger, B., Van Slyke, C.E., and Westerfield, M. (2008) The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes Nucleic Acids Res.36:D768-772.
Mabee, P.M., Arratia, G., Coburn, M., Haendel, M., Hilton, E.J., Lundberg, J.G., Mayden, R.L., Rios, N., and Westerfield, M. (2007) Connecting evolutionary morphology to genomics using ontologies: a case study from Cypriniformes including zebrafish J. Exp. Zool. B Mol. Dev. Evol.308(5):655-668.
Mabee, P.M., Ashburner, M., Cronk, Q., Gkoutos, G.V., Haendel, M., Segerdell, E., Mungall, C., and Westerfield, M. (2007) Phenotype ontologies: the bridge between genomics and evolution Trends Ecol. Evol.22(7):345-350.
Nixon, S.J., Carter, A., Wegner, J., Ferguson, C., Floetenmeyer, M., Riches, J., Key, B., Westerfield, M., and Parton, R.G. (2007) Caveolin-1 is required for lateral line neuromast and notochord development J. Cell Sci.120(13):2151-2161.
Schlueter, P.J., Peng, G., Westerfield, M., and Duan, C. (2007) Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression Cell Death Differ.14(6):1095-1105.
Hans, S., and Westerfield, M. (2007) Changes in retinoic acid signaling alter otic patterning Development134(13):2449-2458.
Hans, S., Christison, J., Liu, D., and Westerfield, M. (2007) Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b BMC Dev. Biol.7(1):5.
Chen, Y.H., Wang, Y.H., Chang, M.Y., Lin, C.Y., Weng, C.W., Westerfield, M., and Tsai, H.J. (2007) Multiple upstream modules regulate zebrafish myf5 expression BMC Dev. Biol.7(1):1.
Westerfield, M. (2007) The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio), 5th Edition University of Oregon Press, Eugene.
Ochi, H., and Westerfield, M. (2007) Signaling networks that regulate muscle development: lessons from zebrafish Dev. Growth Differ.49(1):1-11.
Ochi, H., Pearson, B.J., Chuang, P.T., Hammerschmidt, M., and Westerfield, M. (2006) Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened Dev. Biol.297(1):127-140.
Ramsay, J.M., Feist, G.W., Varga, Z.M., Westerfield, M., Kent, M.L., and Schreck, C.B. (2006) Whole-body cortisol is an indicator of crowding stress in adult zebrafish, Danio rerio Aquaculture258(1-4):565-574.
Peng, G., and Westerfield, M. (2006) Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists Development133(16):3191-3200.
Sprague, J., Bayraktaroglu, L., Clements, D., Conlin, T., Fashena, D., Frazer, K., Haendel, M., Howe, D.G., Mani, P., Ramachandran, S., Schaper, K., Segerdell, E., Song, P., Sprunger, B., Taylor, S., Van Slyke, C.E., and Westerfield, M. (2006) The Zebrafish Information Network: the zebrafish model organism database Nucleic Acids Res.34:D581-585.
Nixon, S.J., Wegner, J., Ferguson, C., Méry, P.F., Hancock, J.F., Currie, P.D., Key, B., Westerfield, M., and Parton, R.G. (2005) Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning Hum. Mol. Genet.14(13):1727-1743.
Dutta, S., Dietrich, J.E., Aspock, G., Burdine, R.D., Schier, A., Westerfield, M., and Varga, Z.M. (2005) pitx3 defines an equivalence domain for lens and anterior pituitary placode Development132(7):1579-1590.
Yan, Y.L., Willoughby, J., Liu, D., Crump, J.G., Wilson, C., Miller, C.T., Singer, A., Kimmel, C., Westerfield, M., and Postlethwait, J.H. (2005) A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development Development132(5):1069-1083.
Wang-Buhler, J.L., Lee, S.J., Chung, W.G., Stevens, J.F., Tseng, H.P., Hseu, T.H., Hu, C.H., Westerfield, M., Yang, Y.H., Miranda, C.L., and Buhler, D.R. (2005) CYP2K6 from zebrafish (Danio rerio): Cloning, mapping, developmental/tissue expression, and aflatoxin B1 activation by baculovirus expressed enzyme Comp. Biochem. Physiol. C Toxicol. Pharmacol.140(2):207-219.
Wiellette, E., Grinblat, Y., Austen, M., Hirsinger, E., Amsterdam, A., Walker, C., Westerfield, M., and Sive, H. (2004) Combined haploid and insertional mutation screen in the zebrafish Genesis40(4):231-240.
Hirsinger, E., Stellabotte, F., Devoto, S.H., and Westerfield, M. (2004) Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors Dev. Biol.275(1):143-157.
Hans, S., Liu, D., and Westerfield, M. (2004) Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors Development131(20):5091-5102.
Henrich, T., Ramialison, M., Segerdell, E., Westerfield, M., Furutani-Seiki, M., Wittbrodt, J., Kondoh, H. (2004) GSD: a genetic screen database Mech. Dev.121(7-8):959-963.
Jensen, A.M., and Westerfield, M. (2004) Zebrafish Mosaic Eyes Is a Novel FERM Protein Required for Retinal Lamination and Retinal Pigmented Epithelial Tight Junction Formation Curr. Biol.14(8):711-717.
Liu, D., Chu, H., Maves, L., Yan, Y.-L., Morcos, P.A., Postlethwait, J.H., and Westerfield, M. (2003) Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification Development130(10):2213-2224.
Sprague, J., Clements, D., Conlin, T., Edwards, P., Frazer, K., Schaper, K., Segerdell, E., Song, P., Sprunger, B., and Westerfield, M. (2003) The Zebrafish Information Network (ZFIN): the zebrafish model organism database Nucleic Acids Res.31(1):241-243.
Yan, Y.-L., Miller, C.T., Nissen, R.M., Singer, A., Liu, D., Kirn, A., Draper, B., Willoughby, J., Morcos, P.A., Amsterdam, A., Chung, B.-C., Westerfield, M., Haffter, P., Hopkins, N., Kimmel, C., and Postlethwait, J.H. (2002) A zebrafish sox9 gene required for cartilage morphogenesis Development129(21):5065-5079.
Jensen, A.M., Walker, C., and Westerfield, M. (2001) mosaic eyes: a zebrafish gene required in pigmented epithelium for apical localization of retinal cell division and lamination Development128(1):95-105.
Varga, Z.M., Amores, A., Lewis, K.E., Yan, Y.-L., Postlethwait, J.H., Eisen, J.S., and Westerfield, M. (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation Development128(18):3497-3509.
Hawkins, W.E., Clark, M.S., Shima, A., Walter, R.B., Winn, R.N., and Westerfield, M. (2001) Four resource centers for fishes: specifies, stocks, and services Mar. Biotechnol.3:S239-S248.
Hirsinger, E. and Westerfield, M. (2001) Segregation of zebrafish muscle lineages: lineage relationships and cellular commitment Dev. Biol.235(1):180 (#40).
Jensen, A.M. and Westerfield, M. (2001) Zebrafish mosaic eyes gene is required for tight junction formation in the retinal pigmented epithelium Dev. Biol.235(1):181 (#46).
Sprague, J., Doerry, E., Douglas, S., Westerfield, M., and ZFIN GRP, (Conlin, T., Clements, D., Edwards, P., Frazer, K., Schaper, K., Segerdell, E.) (2001) The Zebrafish Information Network (ZFIN): a resource for genetic, genomic and developmental research Nucleic Acids Res.29(1):87-90.
Whitlock, K.E. and Westerfield, M. (2000) The olfactory placodes of the zebrafish form by convergence of cellular fields at the edge of the neural plate Development127(17):3645-3653.
Westerfield, M. (2000) The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio), 4th Edition University of Oregon Press, Eugene.
Varga, Z.M., Wegner, J., and Westerfield, M. (1999) Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops Development126:5533-5546.
Westerfield, M., Doerry, E., and Douglas, S. (1999) Zebrafish in the net Trends Genet.15(6):248-249.
Fashena, D. and Westerfield, M. (1999) Secondary motoneuron axons localize DM-GRASP on their fasciculated segments J. Comp. Neurol.406(3):415-424.
Appel, B., Fritz, A., Westerfield, M., Grunwald, D.J., Eisen, J.S., and Riley, B.B. (1999) Delta-mediated specification of midline cell fates in zebrafish embryos Curr. Biol.9:247-256.
Detrich, H.W. III, Westerfield, M., and Zon, L.I. (1999) Overview of the zebrafish system. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds Meth. Cell. Biol.59:3-10.
Detrich, H.W. III, Westerfield, M., and Zon, L.I., eds. (1999) The Zebrafish: Genetics and Genomics San Diego: Academic Press60:407.
Westerfield, M., Doerry, E., Kirkpatrick, A.E., and Douglas, S.A. (1999) Zebrafish informatics and the ZFIN database In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.60:339-355.
Detrich, H.W. III, Westerfield, M., and Zon, L.I., eds. (1999) The Zebrafish: Biology San Diego: Academic Press, Methods Cell Biol.59:391.
Doerry, E., Douglas, S.A., Kirkpatrick, A.E., and Westerfield, M. (1998) The zebrafish information network project Interactions3:69.
Amores, A., Force, A., Yan, Y.-L. Joly, L., Amemiya, C., Fritz, A., Ho, R., Langeland, J., Prince, V., Wang, Y.-L., Westerfield, M., Ekker, M., and Postlethwait, J.H. (1998) Zebrafish hox clusters and vertebrate genome evolution Science282:1711-1714.
Whitlock, K.E. and Westerfield, M. (1998) A transient population of neurons pioneers the olfactory pathway in the zebrafish J. Neurosci.18:8919-8927.
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map Nat. Genet.18:345-349.
Houart, C., M. Westerfield, and S.W. Wilson (1998) A small population of anterior cells patterns the forebrain during gastrulation Nature391:788-792.
Sepich, D.S., Wegner, J., O'Shea, S., and Westerfield, M. (1998) An altered intron inhibits synthesis of the acetylcholine receptor alpha-subunit in the paralyzed zebrafish mutant nic1 Genetics184:361-372.
Doerry, E., Kirkpatrick, A.E., Douglas, S.A., and Westerfield, M. (1997) Task-centered Navigation in a Web-accessible Data Space AACE/WebNet97 conference on WWW, Internet, and Intranet, Toronto, Canada, Nov. 1,1997.
Melançon, E., Liu, D.W.C., Westerfield, M., and Eisen, J.S. (1997) Pathfinding by identified zebrafish motoneurons in the absence of muscle pioneers J. Neurosci.17(20):7796-7804.
Fishman, M., D.Y. Stainier, R. Breitbart, and M. Westerfield (1997) Zebrafish: Genetic and embryological methods in a transparent vertebrate embryo Meth. Cell. Biol.52:67-82.
Du, S.J., S.H. Devoto, M. Westerfield, and R.T. Moon (1997) Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-b gene families J. Cell Biol.139:145-156.
Doerry, E., Douglas, S., Kirkpatrick, T., and Westerfield, M. (1997) Moving beyond html to create a multimedia database with user-centered design: a case study of a biological database Tech. Report CIS-TR-97-02, Computer and Information Science Department, University of Oregon.
Doerry, E., Douglas, S.A., Kirkpatrick, A.E., and Westerfield, M. (1997) Participatory design for widely-distributed scientific communities Proc. 3rd Conf. Human Factors and the Web.
Ekker, M., Akimenko, M.-A., Allende, M.L., Smith, R., Drouin, G., Langille, R.M., Weinberg, E.S., and Westerfield, M. (1997) Relationships among msx gene structure and function in zebrafish and other vertebrates Mol. Biol. Evol.14:1008-1022.
Westerfield, M., E. Doerry, A.E. Kirkpatrick, W. Driever, and S.A. Douglas (1997) An on-line database for zebrafish development and genetics research Sem. Cell Dev. Biol.8:477-488.
Fritz, A., Rozowski, M., Walker, C., and Westerfield, M. (1996) Identification of selected gamma-ray induced deficiencies in zebrafish using multiplex polymerase chain reaction Genetics144(4):1735-1745.
Devoto, S.H., Melancon, E., Eisen, J.S., and Westerfield, M. (1996) Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation Development122(11):3371-3380.
Devoto, S.H., Melancon, E., Amacher, S.L., Eisen, J.S., and Westerfield, M. (1996) Influence of axial mesoderm on the development of slow muscle precursors Dev. Biol.175(2):386.
Westerfield, M. (1995) The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio), 3rd Edition Eugene, OR, University of Oregon Press,:385.
Akimenko, M.A., Johnson, S.L., Westerfield, M., and Ekker, M. (1995) Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish Development121:347-357.
Akimenko, M.A., Ekker, M., Wegner, J., Lin, W., and Westerfield, M. (1994) Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head J. Neurosci.14:3475-3486.
Sepich, D.S., Ho, R.K., and Westerfield, M. (1994) Autonomous expression of the nic1 acetylcholine receptor mutation in zebrafish muscle cells Dev. Biol.161:84-90.
Reinhard, E., Nedivi, E., Wegner, J., Skene, J.H.P., and Westerfield, M. (1994) Neural selective activation and temporal regulation of a mammalian GAP-43 promoter in zebrafish Development120:1767-1775.
Westerfield, M. and Liu, D.W. (1993) Cellular interactions regulating the formation of terminal arbors by primary motoneurons in the zebrafish In Cell-Cell Signaling in Vertebrate Development, E. Robertson, F.R. Maxfield, and H.J. Vogel, eds., Academic Press:113-122.
Westerfield, M., Stuart, G., and Wegner, J. (1993) Expression of foreign genes in zebrafish embryos In Devel. Ind. Microbiol., Vol II, William C. Brown, ed., New York:658-665.
Westerfield, M. (1993) The Zebrafish Book; A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio) University of Oregon Press, Eugene,2nd edition:300P.
Westerfield, M., Akimenko, M.A., Ekker, M., and Püschel, A. (1993) Eyes, ears and homeobox genes in zebrafish embryos In Molecular Basis of Morphogenesis, M. Bernfield, ed., New York, NY: John Wiley & Sons, Wiley-Liss Division:67-75.
Püschel, A.W., Gruss, P., and Westerfield, M. (1992) Sequence and expression pattern of pax-6 are highly conserved between zebrafish and mice Development114:643-651.
Westerfield, M., Wegner, J., Jegalian, B.G., De Robertis, E.M., and Püschel, A.W. (1992) Specific activation of mammalian Hox promoters in mosaic transgenic zebrafish Genes Dev.6:591-598.
Ekker, M., Fritz, A., and Westerfield, M. (1992) Identification of two families of satellite-like repetitive DNA sequences from the zebrafish (Brachydanio rerio) Genomics13:1169-1173.
Püschel, A.W., Westerfield, M., and Dressler, G.R. (1992) Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish Mech. Dev.38:197-208.
Ekker, M., Akimenko, M.A., BreMiller, R., and Westerfield, M. (1992) Regional expression of three homeobox transcripts in the inner ear of zebrafish embryos Neuron9:27-35.
Goff, D.J., Galvin, K., Katz, H., Westerfield, M., Lander, E.S., and Tabin, C.J. (1992) Identification of polymorphic simple sequence repeats in the genome of the zebrafish Genomics14:200-202.
Ekker, M., Wegner, J., Akimenko, M.A., and Westerfield, M. (1992) Coordinate embryonic expression of three zebrafish engrailed genes Development116:1001-1010.
Liu, D.W. and Westerfield, M. (1992) Clustering of muscle acetylcholine receptors requires motoneurons in live embryos but not in cell culture J. Neurosci.12:1859-1866.
Westerfield, M. (1992) Zebrafish Hox and Pax genes Neurosci. Facts3:3.
Westerfield, M. (1992) Motor axon pathfinding Curr. Opin. Neurobiol.2:28-30.
Westerfield, M., Wegner, J., Akimenko, M., Ekker, M., Eisen, J., and Halpern, M. (1991) A role for engrailed gene in zebrafish muscle patterning Soc. Neurosci. Abstr.17:761.
Hatta, K., BreMiller, R.A., Westerfield, M., and Kimmel, C.B. (1991) Diversity of expression of engrailed-like antigens in zebrafish Development112:821-832.
Ekker, M., Akimenko, M.A., BreMiller, R., and Westerfield, M. (1991) Characterization of four homeobox genes expressed in zebrafish neural crest Soc. Neurosci. Abstr.17:924.
Westerfield, M. (1990) Does the mesoderm induce Hox gene expression in the zebrafish nervous system? Soc. Neurosci. Abstr.16:302.
Metcalfe, W.K. and Westerfield, M. (1990) Primary motoneurons of the zebrafish In Systems Approaches to Developmental Neurobiology, P.A. Raymond, S.S. Easter and G.M. Innocenti, eds., NATO ASI Series A,New York: Plenum Press192:41-47.
Kimmel, C.B. and Westerfield, M. (1990) Primary neurons of the zebrafish In Signal and Sense, G.M. Edelman, W.E. Gall, and M.W. Cowan, eds., New York: Wiley-Liss:561-588.
Stuart, G.W., Vielkind, J.R., McMurray, J.V., and Westerfield, M. (1990) Stable lines of transgenic zebrafish exhibit reproducible patterns of transgene expression Development109:577-584.
Akimenko, M.A., Ekker, M., and Westerfield, M. (1990) Characterization of three zebrafish genes related to Hox-7 In Developmental Patterning of the Vertebrate Limb, J.R. Hinchliffe, J. Hurle and D. Summerbell, eds., New York: Plenum Press:61-63.
Felsenfeld, A.L., Walker, C., Westerfield, M., Kimmel, C., and Streisinger, G. (1990) Mutations affecting skeletal muscle myofibril structure in the zebrafish Development108:443-459.
Liu, D.W.C. and Westerfield, M. (1990) The formation of terminal fields in the absence of competitive interactions among primary motoneurons in the zebrafish J. Neurosci.10:3947-3959.
Westerfield, M., Liu, D.W., Kimmel, C.B., and Walker, C. (1990) Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors Neuron4:867-874.
Stuart, G.W., McMurray, J.V., and Westerfield, M. (1989) Germ-line transformation of the zebrafish In Gene Transfer and Gene Therapy, A.L. Beaudet, R. Mulligan, and I. M. Verma, eds., New York, NY, USA: Alan R. Liss, Inc.:19-28.
Westerfield, M. (1989) The Zebrafish Book; A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio) University of Oregon Press, Eugene.
Liu, D.W. and Westerfield, M. (1989) Primary motoneurons instruct muscle acetylcholine receptor placement but receptors don't instruct motoneuronal synapse placement in live zebrafish Soc. Neurosci. Abstr.15:1262.
Hanneman, E. and Westerfield, M. (1989) Early expression of acetylcholinesterase activity in functionally distinct neurons of the zebrafish J. Comp. Neurol.284:350-361.
Westerfield, M. (1989) Establishment of cell-specific differences among primary motoneurons in the zebrafish In The Assembly of the Nervous System. Landmesser, L.T., ed., New York, NY, USA: Alan R. Liss, Inc.:189-198.
Debu B., Frost, D., Westerfield M., Eisen J.S. (1989) Patterning of primary motoneuron axonal outgrowth by extracellular matrix molecules in zebrafish embryos Soc. Dev. Biol. Mtg. Abstr.
Stuart, G.W., McMurray, J.V., and Westerfield, M. (1988) Replication, integration and stable germ-line transmission of foreign sequences injected into early zebrafish embryos Development103:403-412.
Grunwald, D.J., Kimmel, C.B., Westerfield, M., Walker, C., and Streisinger, G. (1988) A neural degeneration mutation that spares primary neurons in the zebrafish Dev. Biol.126:115-128.
Bass, M.B. and Westerfield, M. (1988) Purification of neuron-specific antigens from zebrafish Soc. Neurosci. Abstr.14:1267.
Liu, D.W. and Westerfield, M. (1988) Function of identified motoneurones and co-ordination of primary and secondary motor systems during zebra fish swimming J. Physiol. Lond.403:73-89.
Hanneman, E., Trevarrow, B., Metcalfe, W.K., Kimmel, C.B., and Westerfield, M. (1988) Segmental pattern of development of the hindbrain and spinal cord of the zebrafish embryo Development103:49-58.
Stuart, G.W., McMurray, J.V., and Westerfield, M. (1988) Germ-line transformation of the zebrafish Brachydanio-rerio J. Cell. Biochem.(Suppl.) 12:195.
Frost, D., Debu B., Eisen J.S., and Westerfield M. (1988) Axonal outgrowth in embryonic zebrafish is perturbed by ectopic localization of fibronectin in vivo Soc. Dev. Biol. Mtg. Abstr.
Westerfield, M. and Eisen, J.S. (1988) Neuromuscular specificity: pathfinding by identified motor growth cones in a vertebrate embryo Trends Neurosci.11:18-22.
Westerfield, M. (1987) Substrate interactions affecting motor growth cone guidance during development and regeneration J. Exp. Biol.132:161-176.
Westerfield, M. and Eisen, J.S. (1987) Common mechanisms of growth cone guidance during axonal pathfinding In From Message to Mind: New Directions in the Developmental Neurobiology, Sinauer Assoc.:110-120.
Westerfield, M., Kimmel, C.B., and Walker, C. (1987) Normal pathfinding by pioneer motor growth cones in mutant zebrafish lacking functional acetylcholine receptors Soc. Neurosci. Abstr.13:5.
Liu, D.W. and Westerfield, M. (1987) The formation of terminal fields by identified motoneurons in the zebrafish Anim. Behav.35:1875-1882.
Eisen, J.S., Myers, P.Z., and Westerfield, M. (1986) Pathway selection by growth cones of identified motoneurones in live zebra fish embryos Nature320(6059):269-271.
Felsenfeld, A. and Westerfield, M. (1986) Normal pathfinding and synapse formation by motoneurons in a non-motile mutant zebrafish embryo Soc. Neurosci. Abstr.147:12.
Myers, P.Z., Eisen, J.S., and Westerfield, M. (1986) Development and axonal outgrowth of identified motoneurons in the zebrafish J. Neurosci.6:2278-2289.
Liu, D. and Westerfield, M. (1986) Coactivation of two motor systems in the zebrafish Soc. Neurosci. Abstr.2:790.
Westerfield, M., Eisen, J.S., Myers, P.Z., McMurray, J.V., and Kimmel, C.B. (1986) Early neurogenesis in the zebrafish Proc. Int. Union Physiol. Sci.16:20.
Frost, D. and Westerfield, M. (1986) Axonal outgrowth of embryonic zebrafish neurons is promoted by laminin and inhibited by fibronectin Soc. Neurosci. Abstr.12:1114.
Westerfield, M., McMurray, J.V., and Eisen, J.S. (1986) Identified motoneurons and their innervation of axial muscles in the zebrafish J. Neurosci.6:2267-2277.
Kimmel, C.B., Grunwald, D.J., Walker, C., Westerfield, M., and Streisinger, G. (1985) Neuronal degeneration mutations that spare primary neurons in the zebrafish Soc. Neurosci. Abstr.11:647.
Eisen, J.S., Myers, P.Z., and Westerfield, M. (1985) Functional interactions between identified growth cones and muscles in embryonic zebrafish Soc. Neurosci. Abstr.11:586.
Westerfield, M. and Eisen, J.S. (1985) The growth of motor axons in the spinal cord of Xenopus embryos Dev. Biol.109:96-121.
Westerfield, M., Myers, P.Z., and Eisen, J.S. (1984) Polyneuronal and intersegmental innervation of body muscles in the zebrafish Soc. Neurosci. Abstr.10:371.
Hanneman, E. and Westerfield, M. (1984) Identified neurons produce acetylcholinesterase before they sprout axons in the zebrafish Soc. Neurosci. Abstr.10:1043.
Eisen, J.S., Myers, P.Z., and Westerfield, M. (1984) Segmentally specific growth of motor axons in live zebrafish embryos Soc. Neurosci. Abstr.10:371.

NON-ZEBRAFISH PUBLICATIONS
Westerfield, M., and J.S. Eisen. (1985). The growth of motor axons in the spinal cord of Xenopus embryos. Devel. Biol. 109:96-121.

Powell, S.L., and M. Westerfield. (1984). The absence of specific dye coupling among frog spinal cord neurons. Brain Res. 294:9-14.

Westerfield, M., and S.L. Powell. (1983). Selective reinnervation of limb muscles by regenerating frog motor axons. Devel. Brain Res. 10:301-304.

Frank, E., and M. Westerfield. (1983). Development of sensory-motor synapses in the spinal cord of the frog. J. Physiol. (Lond.) 343:593-610.

Moore, J.W., N. Stockbridge and M. Westerfield. (1983). On the site of impulse initiation in a neurone. J. Physiol. (Lond.) 336:301-311.

Moore, J.W., and M. Westerfield. (1983). Action potential propagation and threshold parameters in inhomogeneous regions of squid axons. J. Physiol. (Lond.) 336:285-300.

Westerfield, M., and E. Frank. (1982). Specificity of electrical coupling among neurons innervating forelimb muscles of the adult bullfrog. J. Neurophysiol. 48:904-913.

Westerfield., M., and R.W. Joyner. (1982). Postsynaptic factors controlling the shape of potentials at the squid giant synapse.
Neuroscience. 7:1367-1376.

Frank, E., and M. Westerfield. (1982). The formation of appropriate central and peripheral connexions by foreign sensory neurones of the bullfrog. J. Physiol. (Lond.) 324:495-505.

Frank, E., and M. Westerfield. (1982). Synaptic organization of sensory and motor neurones innervating triceps brachii muscles in the bullfrog. J. Physiol. (Lond.) 324:479-494.

Joyner, R.W., and M. Westerfield. (1982). The effects of rectification on synaptic efficacy. Biophys. J. 38:3946.

Westerfield, M. and H.D. Lux. (1982). Calcium activated potassium conductance noise in snail neurons. J. Neurobiol. 12:507-517.

Gage, P.W., J.W. Moore and M. Westerfield. (1976) An octopus toxin,
maculotoxin, selectively blocks sodium current in squid axon.
J. Physiol. (Lond.). 259:427-443.

Joyner, R.W., M. Westerfield and J.W. Moore. (1980). The effects of cellular geometry on current flow during action potential propagation. Biophys. J. 31:183-194.

Westerfield, M., J.W. Moore, Y.S. Kim and G. Padilla. (1977). How Gymnodinium breve red tide toxin produces repetitive firing in squid axons. Amer. J. Physiol. 232:23-29.

Westerfield, M., and H.D. Lux. (1979). Two components of membrane conductance noise in snail neuronal somata. Neurosci. Lett. 11:75-80.

Westerfield, M., R.W. Joyner and J.W. Moore. (1978). Temperature sensitive conduction failure at axon branch points. J. Neurophysiol. 41:1-8.

Joyner, R.W., M. Westerfield, J.W. Moore and N. Stockbridge. (1978). A
numerical method to model excitable cells. Biophys. J. 22:155-170.

Ramon, F., J.W. Moore, R.W. Joyner and M. Westerfield (1976) Squid giant axon as a model for the neuron soma? Biophys. J. 16:953-963.

Kim, Y.S., L. Mandel, M. Westerfield, G. Padilla and J.W. Moore. (1975) Effect of Gymnodinium breve toxin(s) on frog skin and giant axon of the squid. Environ. Lett. 9:255-264.