PUBLICATION
Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish
- Authors
- Wang, Y., Liu, W., Yang, J., Wang, F., Yizhen, S., Zhong, Z.M., Wang, H., Hu, L.F., Liu, C.F.
- ID
- ZDB-PUB-161122-9
- Date
- 2017
- Source
- Neurotoxicology 58: 103-109 (Journal)
- Registered Authors
- Liu, Chun-Feng, Liu, Wenwen, Wang, Fen, Wang, Han, Wang, Yali
- Keywords
- Parkinson’s disease, non-motor symptoms, rotenone, zebrafish
- MeSH Terms
-
- Animals
- Anxiety/etiology*
- Dark Adaptation/drug effects
- Disease Models, Animal
- Gene Expression Regulation/drug effects
- Insecticides/toxicity*
- Locomotion/drug effects
- Male
- Neurotransmitter Agents/metabolism
- Olfaction Disorders/etiology*
- Parkinson Disease, Secondary/chemically induced*
- Parkinson Disease, Secondary/complications*
- RNA, Messenger/metabolism
- Rotenone/toxicity*
- Zebrafish
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 27866991 Full text @ Neurotoxicology
- CTD
- 27866991
Citation
Wang, Y., Liu, W., Yang, J., Wang, F., Yizhen, S., Zhong, Z.M., Wang, H., Hu, L.F., Liu, C.F. (2017) Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish. Neurotoxicology. 58:103-109.
Abstract
The pesticide rotenone is widely used to produce Parkinson's disease (PD)-like symptoms in rodents, but few studies have examined whether rotenone-treated zebrafish can serve as an animal model of PD. Here, we report that 4 weeks of rotenone treatment induced motor and non-motor PD-like symptoms in adult zebrafish. Compared with control fish, rotenone-treated fish spent less time swimming at a fast speed, indicating a deficit in motor function. In the light-dark box test, rotenone-treated fish exhibited longer latencies to enter the dark compartment and spent more time in the light compartment, reflecting anxiety- and depression-like behavior. Furthermore, rotenone-treated fish showed less of an olfactory preference for amino acid, indicating olfactory dysfunction. These behavioral symptoms were associated with decreased levels of dopamine in the brains of rotenone-treated fish. Taken together, these results suggest that rotenone-treated zebrafish are a suitable model of PD.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping