PUBLICATION
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig
- Authors
- Liu, J., Zhu, Y., Luo, G.Z., Wang, X., Yue, Y., Wang, X., Zong, X., Chen, K., Yin, H., Fu, Y., Han, D., Wang, Y., Chen, D., He, C.
- ID
- ZDB-PUB-161008-11
- Date
- 2016
- Source
- Nature communications 7: 13052 (Journal)
- Registered Authors
- Chen, Kai, He, Chuan
- Keywords
- Chemical modification, DNA methylation, Embryogenesis
- Datasets
- GEO:GSE76740
- MeSH Terms
-
- Animals
- DNA/chemistry*
- DNA Methylation/genetics*
- Deoxyadenosines/chemistry*
- Embryonic Development/genetics*
- Genome
- Repetitive Sequences, Nucleic Acid/genetics
- Swine/embryology*
- Swine/genetics
- Zebrafish/embryology*
- Zebrafish/genetics
- PubMed
- 27713410 Full text @ Nat. Commun.
Citation
Liu, J., Zhu, Y., Luo, G.Z., Wang, X., Yue, Y., Wang, X., Zong, X., Chen, K., Yin, H., Fu, Y., Han, D., Wang, Y., Chen, D., He, C. (2016) Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Nature communications. 7:13052.
Abstract
DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping