ZFIN ID: ZDB-PUB-160211-14
Luminescence- and nanoparticle-mediated increase of light absorption by photoreceptor cells: Converting UV light to visible light
Li, L., Sahi, S.K., Peng, M., Lee, E.B., Ma, L., Wojtowicz, J.L., Malin, J.H., Chen, W.
Date: 2016
Source: Scientific Reports   6: 20821 (Journal)
Registered Authors: Li, Lei
Keywords: Biotechnology, Neuroscience
MeSH Terms:
  • Animals
  • Disease Models, Animal
  • Light*
  • Nanoparticles/radiation effects*
  • Optical Devices*
  • Photoreceptor Cells/physiology*
  • Photoreceptor Cells/radiation effects*
  • Retinal Degeneration
  • Ultraviolet Rays*
  • Zebrafish
PubMed: 26860393 Full text @ Sci. Rep.
We developed new optic devices - singly-doped luminescence glasses and nanoparticle-coated lenses that convert UV light to visible light - for improvement of visual system functions. Tb(3+) or Eu(3+) singly-doped borate glasses or CdS-quantum dot (CdS-QD) coated lenses efficiently convert UV light to 542 nm or 613 nm wavelength narrow-band green or red light, or wide-spectrum white light, and thereby provide extra visible light to the eye. In zebrafish (wild-type larvae and adult control animals, retinal degeneration mutants, and light-induced photoreceptor cell degeneration models), the use of Tb(3+) or Eu(3+) doped luminescence glass or CdS-QD coated glass lenses provide additional visible light to the rod and cone photoreceptor cells, and thereby improve the visual system functions. The data provide proof-of-concept for the future development of optic devices for improvement of visual system functions in patients who suffer from photoreceptor cell degeneration or related retinal diseases.