PUBLICATION
Histone Deacetylase: Therapeutic Targets in Retinal Degeneration
- Authors
- Daly, C., Yin, J., Kennedy, B.N.
- ID
- ZDB-PUB-151003-10
- Date
- 2016
- Source
- Advances in experimental medicine and biology 854: 455-61 (Chapter)
- Registered Authors
- Kennedy, Breandan N., Yin, Jun
- Keywords
- Histone deacetylase, Histone deacetylase inhibtors, Retinal degeneration, Retinitis pigmentosa, Zebrafish
- MeSH Terms
-
- Animals
- Apoptosis/drug effects
- Disease Models, Animal
- Histone Deacetylase Inhibitors/pharmacology*
- Histone Deacetylases/metabolism*
- Humans
- Mice
- Photoreceptor Cells/drug effects
- Photoreceptor Cells/metabolism
- Retinal Degeneration/metabolism
- Retinal Degeneration/prevention & control*
- Valproic Acid/pharmacology
- Visual Fields/drug effects*
- Zebrafish
- PubMed
- 26427446 Full text @ Adv. Exp. Med. Biol.
Citation
Daly, C., Yin, J., Kennedy, B.N. (2016) Histone Deacetylase: Therapeutic Targets in Retinal Degeneration. Advances in experimental medicine and biology. 854:455-61.
Abstract
Previous studies report that retinitis pigmentosa (RP) patients treated with the histone deacetylase inhibitor (HDACi) valproic acid (VPA) present with improved visual fields and delayed vision loss. However, other studies report poor efficacy and safety of HDACi in other cohorts of retinal degeneration patients. Furthermore, the molecular mechanisms by which HDACi can improve visual function is unknown, albeit HDACi can attenuate pro-apoptotic stimuli and induce expression of neuroprotective factors. Thus, further analysis of HDACi is warranted in pre-clinical models of retinal degeneration including zebrafish. Analysis of HDAC expression in developing zebrafish reveals diverse temporal expression patterns during development and maturation of visual function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping