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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-000918-2
Kennedy, Breandan N.
Email: brendan.kennedy@ucd.ie
URL: http://www.ucd.ie/conway/ConwayWork/cv_54.html
Affiliation: Kennedy Lab
Address: Dept. Pharmacology Conway Institute of Biomolecular & Biomedical Research University College Dublin Belfield Dublin, 4 Ireland
Country: Ireland
Phone: 353-1-716-6740
Fax: 353-1-269-2749
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Ohnesorge, N., Sasore, T., Hillary, D., Alvarez, Y., Carey, M., Kennedy, B.N. (2019) Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae. Frontiers in pharmacology. 10:508
Buckley, A.M., Dunne, M.R., Lynam-Lennon, N., Kennedy, S.A., Cannon, A., Reynolds, A.L., Maher, S.G., Reynolds, J.V., Kennedy, B.N., O'Sullivan, J. (2019) Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma. Cancer letters. 447:115-129
Ward, R., Sundaramurthi, H., Di Giacomo, V., Kennedy, B.N. (2018) Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish. Frontiers in cell and developmental biology. 6:37
Raghupathy, R.K., Zhang, X., Liu, F., Alhasani, R.H., Biswas, L., Akhtar, S., Pan, L., Moens, C.B., Li, W., Liu, M., Kennedy, B.N., Shu, X. (2017) Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish. Scientific Reports. 7:16881
Daly, C., Shine, L., Heffernan, T., Deeti, S., Reynolds, A.L., O'Connor, J.J., Dillon, E.T., Duffy, D.J., Kolch, W., Cagney, G., Kennedy, B.N. (2017) A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model. Scientific Reports. 7:11320
Leyk, J., Daly, C., Janssen-Bienhold, U., Kennedy, B.N., Richter-Landsberg, C. (2017) HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness. Cell Death & Disease. 8:e3028
Merrigan, S.L., Kennedy, B.N. (2017) Vitamin D Receptor Agonists Regulate Ocular Developmental Angiogenesis and Modulate Expression of dre-miR-21 and VEGF. British journal of pharmacology. 174(16):2636-2651
Tal, T., Kilty, C., Smith, A., LaLone, C., Kennedy, B., Tennant, A., McCollum, C.W., Bondesson, M., Knudsen, T., Padilla, S., Kleinstreuer, N. (2017) Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. Reproductive toxicology (Elmsford, N.Y.). 70:70-81
Butler, C.T., Reynolds, A.L., Tosetto, M., Dillon, E.T., Guiry, P., Cagney, G., O'Sullivan, J., Kennedy, B.A. (2017) A Quininib Analogue and Cysteinyl Leukotreine Receptor Antagonist inhibits VEGF-Independent Angiogenesis and Exerts an Additive Anti-angiogenic Response with Bevacizumab. The Journal of biological chemistry. 292(9):3552-3567
Glaviano, A., Smith, A.J., Blanco, A., McLoughlin, S., Cederlund, M.L., Heffernan, T., Sapetto-Rebow, B., Alvarez, Y., Yin, J., Kennedy, B.N. (2016) A method for isolation of cone photoreceptors from adult zebrafish retinae. BMC Neuroscience. 17:71
Murphy, A.G., Casey, R., Maguire, A., Tosetto, M., Butler, C.T., Conroy, E., Reynolds, A.L., Sheahan, K., O'Donoghue, D., Gallagher, W.M., Fennelly, D., Kennedy, B.N., O'Sullivan, J. (2016) Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer. Scientific Reports. 6:34523
Galvin, O., Srivastava, A., Carroll, O., Kulkarni, R., Dykes, S., Vickers, S., Dickinson, K., Reynolds, A., Kilty, C., Redmond, G., Jones, R., Cheetham, S., Pandit, A., Kennedy, B.N. (2016) A sustained release formulation of novel quininib-hyaluronan microneedles inhibits angiogenesis and retinal vascular permeability in vivo. Journal of controlled release : official journal of the Controlled Release Society. 233:198-207
Sulaiman, R.S., Merrigan, S., Quigley, J., Qi, X., Lee, B., Boulton, M.E., Kennedy, B., Seo, S.Y., Corson, T.W. (2016) A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy. Scientific Reports. 6:25509
Reynolds, A.L., Alvarez, Y., Sasore, T., Waghorne, N., Butler, C., Kilty, C., Smith, A.J., McVicar, C., Wong, V.H., Galvin, O., Merrigan, S., Osman, J., Grebnev, G., Sjölander, A., Stitt, A.W., Kennedy, B.N. (2016) Phenotype-Based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis. The Journal of biological chemistry. 291(14):7242-55
Daly, C., Yin, J., Kennedy, B.N. (2016) Histone Deacetylase: Therapeutic Targets in Retinal Degeneration. Advances in experimental medicine and biology. 854:455-61
Yin, J., Morrissey, M.E., Shine, L., Kennedy, C., Higgins, D.G., Kennedy, B.N. (2014) Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis. BMC Genomics. 15:825
Sasore, T., Kennedy, B. (2014) Deciphering Combinations of PI3K/AKT/mTOR Pathway Drugs Augmenting Anti-Angiogenic Efficacy In Vivo. PLoS One. 9:e105280
Deeti, S., O'Farrell, S., and Kennedy, B.N. (2014) Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response. Journal of Pharmacological and Toxicological Methods. 69(1):1-8
Collery, R.F., Cederlund, M.L., and Kennedy, B.N. (2013) Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology. Experimental Eye Research. 108:120-128
Yin, J., Shine, L., Raycroft, F., Deeti, S., Reynolds, A., Ackerman, K.M., Glaviano, A., O'Farrell, S., O'Leary, O., Kilty, C., Kennedy, C., McLoughlin, S., Rice, M., Russell, E., Higgins, D.G., Hyde, D.R., and Kennedy, B.N. (2012) Inhibition of the pim1 oncogene results in diminished visual function. PLoS One. 7(12):e52177
Reynolds, A.L., Blacque, O.E., and Kennedy, B.N. (2012) The genetics of outer segment morphogenesis in zebrafish. Advances in experimental medicine and biology. 723:431-441
Casey, J., Kawaguchi, R., Morrissey, M., Sun, H., McGettigan, P., Nielsen, J.E., Conroy, J., Regan, R., Kenny, E., Cormican, P., Morris, D.W., Tormey, P., Ní Chróinín, M., Kennedy, B.N., Lynch, S., Green, A., and Ennis, S. (2011) First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: A new dimension to the STRA6 phenotype. Human Mutation. 32(12):1417-26
Sapetto-Rebow, B., McLoughlin, S.C., O'Shea, L.C., O'Leary, O., Willer, J.R., Alvarez, Y., Collery, R., O'Sullivan, J., Van Eeden, F., Hensey, C., and Kennedy, B.N. (2011) Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants. BMC Developmental Biology. 11(1):71
Cederlund, M.L., Vendrell, V., Morrissey, M.E., Yin, J., Gaora, P.Ó., Smyth, V.A., Higgins, D.G., and Kennedy, B.N. (2011) mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation. Developmental dynamics : an official publication of the American Association of Anatomists. 240(4):745-754
Cederlund, M.L., Morrissey, M.E., Baden, T., Scholz, D., Vendrell, V., Lagnado, L., Connaughton, V.P., and Kennedy, B.N. (2011) Zebrafish Tg(7.2mab21l2:EGFP)ucd2 Transgenics Reveal a Unique Population of Retinal Amacrine Cells. Investigative ophthalmology & visual science. 52(3):1613-21
Morrissey, M.E., Shelton, S., Brockerhoff, S.E., Hurley, J.B., and Kennedy, B.N. (2011) PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors. BMC Developmental Biology. 11:3
Atzei, P., Yang, F., Collery, R., Kennedy, B.N., and Moynagh, P.N. (2010) Characterisation of expression patterns and functional role of Cactin in early zebrafish development. Gene expression patterns : GEP. 10(4-5):199-206
Alvarez, Y., Chen, K., Reynolds, A.L., Waghorne, N., O'Connor, J.J., and Kennedy, B.N. (2010) Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy. Disease models & mechanisms. 3(3-4):236-245
Yin, J., McLoughlin, S., Jeffery, I.B., Glaviano, A., Kennedy, B., and Higgins, D.G. (2010) Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data. BMC Genomics. 11:50
Collery, R.F., and Kennedy, B.N. (2010) Photoreceptor Guanylate Cyclases and cGMP Phosphodiesterases in Zebrafish. Advances in experimental medicine and biology. 664:55-61
Alvarez, Y., Astudillo, O., Jensen, L., Reynolds, A.L., Waghorne, N., Brazil, D.P., Cao, Y., O'Connor, J.J., and Kennedy, B.N. (2009) Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase. PLoS One. 4(11):e7867
Collery, R., McLoughlin, S., Vendrell, V., Finnegan, J., Crabb, J.W., Saari, J.C., and Kennedy, B.N. (2008) Duplication and divergence of zebrafish CRALBP genes uncovers novel role for RPE- and Muller-CRALBP in cone vision. Investigative ophthalmology & visual science. 49(9):3812-3820
Smyth, V.A., Di Lorenzo, D., and Kennedy, B.N. (2008) A novel, evolutionary conserved enhancer of cone photoreceptor-specific expression. The Journal of biological chemistry. 283(16):10881-10891
Alvarez, Y., Cederlund, M.L., Cottell, D.C., Bill, B.R., Ekker, S.C., Torres-Vazquez, J., Weinstein, B.M., Hyde, D.R., Vihtelic, T.S., and Kennedy, B.N. (2007) Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Developmental Biology. 7(1):114
Kennedy, B.N., Alvarez, Y., Brockerhoff, S.E., Stearns, G.W., Sapetto-Rebow, B., Taylor, M.R., and Hurley, J.B. (2007) Identification of a Zebrafish Cone Photoreceptor-Specific Promoter and Genetic Rescue of Achromatopsia in the nof Mutant. Investigative ophthalmology & visual science. 48(2):522-529
Collery, R.F., Cederlund, M.L., Smyth, V.A., and Kennedy, B.N. (2006) Applying transgenic zebrafish technology to study the retina. Advances in experimental medicine and biology. 572(1):201-207
Kennedy, B.N., Stearns, G.W., Smyth, V.A., Ramamurthy, V., van Eeden, F., Ankoudinova, I., Raible, D., Hurley, J.B., and Brockerhoff, S.E. (2004) Zebrafish rx3 and mab21l2 are required during eye morphogenesis. Developmental Biology. 270(2):336-349
Brockerhoff, S.E., Rieke, F., Matthews, H.R., Taylor, M.R., Kennedy, B., Ankoudinova, I., Niemi, G.A., Tucker, C.L., Xiao, M., Cilluffo, M.C., Fain, G.L., and Hurley, J.B. (2003) Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(2):470-480
Kennedy, B.N., Vihtelic, T.S., Checkley, L., Vaughan, K.T., and Hyde, D.R. (2001) Isolation of a zebrafish rod opsin promoter to generate a transgenic zebrafish line expressing EGFP in rod photoreceptors. The Journal of biological chemistry. 276(17):14037-14043

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