PUBLICATION
Fluoxetine and diazepam acutely modulate stress induced-behavior
- Authors
- Giacomini, A.C., Abreu, M.S., Giacomini, L.V., Siebel, A.M., Zimerman, F.F., Rambo, C.L., Mocelin, R., Bonan, C.D., Piato, A.L., Barcellos, L.J.
- ID
- ZDB-PUB-150926-10
- Date
- 2016
- Source
- Behavioural brain research 296: 301-10 (Journal)
- Registered Authors
- Bonan, Carla Denise
- Keywords
- aggressiveness, memory, novel tank, social behavior, zebrafish
- MeSH Terms
-
- Aggression*/drug effects
- Aggression*/physiology
- Animals
- Behavior, Animal*/drug effects
- Behavior, Animal*/physiology
- Diazepam/administration & dosage
- Diazepam/pharmacology*
- Disease Models, Animal
- Female
- Fluoxetine/administration & dosage
- Fluoxetine/pharmacology*
- GABA Modulators/administration & dosage
- GABA Modulators/pharmacology*
- Male
- Motor Activity*/drug effects
- Motor Activity*/physiology
- Selective Serotonin Reuptake Inhibitors/administration & dosage
- Selective Serotonin Reuptake Inhibitors/pharmacology*
- Stress, Psychological*/complications
- Stress, Psychological*/drug therapy
- Zebrafish
- PubMed
- 26403161 Full text @ Behav. Brain Res.
Citation
Giacomini, A.C., Abreu, M.S., Giacomini, L.V., Siebel, A.M., Zimerman, F.F., Rambo, C.L., Mocelin, R., Bonan, C.D., Piato, A.L., Barcellos, L.J. (2016) Fluoxetine and diazepam acutely modulate stress induced-behavior. Behavioural brain research. 296:301-10.
Abstract
Drug residue contamination in aquatic ecosystems has been studied extensively, but the behavioral effects exerted by the presence of these drugs are not well known. Here, we investigated the effects of acute stress on anxiety, memory, social interaction, and aggressiveness in zebrafish exposed to fluoxetine and diazepam at concentrations that disrupt the hypothalamic-pituitary-interrenal (HPI) axis. Stress increased the locomotor activity and time spent in the bottom area of the tank (novel tank). Fluoxetine and diazepam prevented these behaviors. We also observed that stress and fluoxetine and diazepam exposures decreased social interaction. Stress also increased aggressive behavior, which was not reversed by fluoxetine or diazepam. These data suggest that the presence of these drugs in aquatic ecosystems causes significant behavioral alterations in fish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping