PUBLICATION
Acute exposure to waterborne psychoactive drugs attract zebrafish
- Authors
- Abreu, M.S., Giacomini, A.C., Gusso, D., Rosa, J.G., Koakoski, G., Kalichak, F., Idalêncio, R., Oliveira, T.A., Barcellos, H.H., Bonan, C.D., Barcellos, L.J.
- ID
- ZDB-PUB-150903-3
- Date
- 2016
- Source
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 179: 37-43 (Journal)
- Registered Authors
- Bonan, Carla Denise
- Keywords
- attractiveness, aversive behavior, behavior, drugs, zebrafish
- MeSH Terms
-
- Animals
- Avoidance Learning/drug effects*
- Avoidance Learning/physiology
- Dose-Response Relationship, Drug
- Female
- Male
- Motor Activity/drug effects
- Motor Activity/physiology
- Psychotropic Drugs/toxicity*
- Water Pollutants, Chemical/toxicity*
- Zebrafish
- PubMed
- 26325205 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Citation
Abreu, M.S., Giacomini, A.C., Gusso, D., Rosa, J.G., Koakoski, G., Kalichak, F., Idalêncio, R., Oliveira, T.A., Barcellos, H.H., Bonan, C.D., Barcellos, L.J. (2016) Acute exposure to waterborne psychoactive drugs attract zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 179:37-43.
Abstract
Psychotropic medications are widely used, and their prescription has increased worldwide, consequently increasing their presence in aquatic environments. Therefore, aquatic organisms can be exposed to psychotropic drugs that may be potentially dangerous, raising the question of whether these drugs are attractive or aversive to fish. To answer this question, adult zebrafish were tested in a chamber that allows the fish to escape or seek a lane of contaminated water. These attraction and aversion paradigms were evaluated by exposing the zebrafish to the presence of acute contamination with these compounds. The zebrafish were attracted by certain concentrations of diazepam, fluoxetine, risperidone and buspirone, which were most likely detected by olfaction, because this behavior was absent in anosmic fish. These findings suggest that despite their deleterious effects, certain psychoactive drugs attract fish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping