PUBLICATION
Chapter 23: Development of the Vertebrate Eye and Retina
- Authors
- Stenkamp, D.L.
- ID
- ZDB-PUB-150828-9
- Date
- 2015
- Source
- Progress in molecular biology and translational science 134: 397-414 (Chapter)
- Registered Authors
- Stenkamp, Deborah L.
- Keywords
- Development, Eye, Morphogenesis, Neurogenesis, Photoreceptor, Regeneration, Retina, Retinal ganglion cell, Zebrafish
- MeSH Terms
-
- Animals
- Humans
- Models, Biological
- Neurogenesis
- Regeneration
- Retina/embryology*
- Retinal Neurons/pathology
- Vertebrates/embryology*
- PubMed
- 26310167 Full text @ Prog. Mol. Biol. Transl. Sci.
Citation
Stenkamp, D.L. (2015) Chapter 23: Development of the Vertebrate Eye and Retina. Progress in molecular biology and translational science. 134:397-414.
Abstract
The mature, functional, and healthy eye is generated by the coordinated regulatory interaction of numerous and diverse developing tissues. The neural retina of the eye must undergo the neurogenesis of multiple retinal cell types in the correct ratios and spatial patterns. This chapter provides an overview of retinal development, and includes a summary of the process of eye organogenesis, a discussion of major principles of retinal neurogenesis, and describes some of the key molecular factors critical for retinal development. Defects in many of these factors underlie diseases of the eye, and an understanding of the process of retinal development will be critical for successful future applications of regenerative therapies for eye disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping