BIOGRAPHY AND RESEARCH INTERESTS
ZFIN ID: ZDB-PERS-970127-2
Dr. Stenkamp's research interests center on the examination of cellular and molecular mechanisms of vertebrate retinal development and regeneration, with a specific focus on photoreceptor differentiation, using zebrafish as the primary experimental model.
One area of current investigation is the involvement of specific factors such as the signaling protein, sonic hedgehog, in regulating the differentiation of rod and cone photoreceptors. The aim is to better define the sources of these factors in the developing retina, and determine their effects on photoreceptors by using gain-of-function and loss-of-function approaches, including the examination of specific zebrafish mutants.
Another area of research is the study of retinal cell patterns in retina that regenerates following a chemical or sugical lesion. A computational approach to describing these patterns has revealed possible distinctions in mechanisms for neurogenesis and cell
differentiation during regeneration as compared to those that operate during normal development and growth. The lab has now begun to carefully compare the processes of ganglion cell regeneration and ganglion cell development using molecular markers.
Dr. David A. Cameron, SUNY Upstate Medical University
McGinn, T.E., Galicia, C.A., Leoni, D.C., Partington, N., Mitchell, D.M., Stenkamp, D.L. (2019) Rewiring the Regenerated Zebrafish Retina: Reemergence of Bipolar Neurons and Cone-Bipolar Circuitry Following an Inner Retinal Lesion. Frontiers in cell and developmental biology. 7:95
McGinn, T.E., Mitchell, D.M., Meighan, P.C., Partington, N., Leoni, D.C., Jenkins, C.E., Varnum, M.D., Stenkamp, D.L. (2017) Restoration of Dendritic Complexity, Functional Connectivity, and Diversity of Regenerated Retinal Bipolar Neurons in Adult Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(1):120-136
Sukeena, J.M., Galicia, C.A., Wilson, J.D., McGinn, T., Boughman, J.W., Robison, B.D., Postlethwait, J.H., Braasch, I., Stenkamp, D.L., Fuerst, P.G. (2016) Characterization and Evolution of the Spotted Gar Retina. Journal of experimental zoology. Part B, Molecular and developmental evolution. 326(7):403-421
Mitchell, D.M., Stevens, C.B., Frey, R.A., Hunter, S.S., Ashino, R., Kawamura, S., Stenkamp, D.L. (2015) Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish. PLoS Genetics. 11:e1005483
Sherpa, T., Lankford, T., McGinn, T.E., Hunter, S.S., Frey, R.A., Sun, C., Ryan, M., Robison, B.D., and Stenkamp, D.L. (2014) Retinal regeneration is facilitated by the presence of surviving neurons. Developmental Neurobiology. 74(9):851-76
Kashyap, B., Pegorsch, L., Frey, R.A., Sun, C., Shelden, E.A., and Stenkamp, D.L. (2014) Eye-specific gene expression following embryonic ethanol exposure in zebrafish: Roles for heat shock factor 1. Reproductive toxicology (Elmsford, N.Y.). 43:111-124
Sherpa, T., Hunter, S.S., Frey, R.A., Robison, B.D., and Stenkamp, D.L. (2011) Retinal proliferation response in the buphthalmic zebrafish, bugeye. Experimental Eye Research. 93(4):424-36
Nelson, S.M., Mahmoud, T., Beaux, M. 2nd, Shapiro, P., McIlroy, D.N., and Stenkamp, D.L. (2010) Toxic and Teratogenic Silica Nanowires in Developing Vertebrate Embryos. Nanomedicine : nanotechnology, biology, and medicine. 6(1):e93-e102
Stenkamp, D.L., Satterfield, R., Muhunthan, K., Sherpa, T., Vihtelic, T.S., and Cameron, D. (2008) Age-Related Cone Abnormalities in Zebrafish with Genetic Lesions in Sonic Hedgehog. Investigative ophthalmology & visual science. 49(10):4631-4640
Sherpa, T., Fimbel, S.M., Mallory, D.E., Maaswinkel, H., Spritzer, S.D., Sand, J.A., Li, L., Hyde, D.R., and Stenkamp, D.L. (2008) Ganglion cell regeneration following whole-retina destruction in zebrafish. Developmental Neurobiology. 68(2):166-181
Rajendran, R.R., Van, Niel, E.E., Stenkamp, D.L., Cunningham, L.L., Raymond, P.A., and Gonzalez-Fernandez, F. (1996) Zebrafish interphotoreceptor retinoid-binding protein: differential circadian expression among cone subtypes. The Journal of experimental biology. 199(12):2775-2787
Wan, J. and D.L. Stenkamp (2000). Cone mosaic development in the goldfish retina is independent of rod neurogenesis and differentiation. J. Comp. Neurol. 423:227-242.
Stenkamp, D.L., L.K. Barthel and P.A. Raymond (1997). Spatiotemporal coordination of rod and cone differentiation in goldfish retina. J. Comp. Neurol. 382:272-284.
Stenkamp, D.L., O. Hisatomi, L.K. Barthel, F. Tokunaga and P.A. Raymond (1996). Temporal expression of rod and cone opsins in embryonic goldfish retina predicts the spatial organization of the cone mosaic. Inves. Ophthalmol. Vis. Sci. 37:363-376.