|ZFIN ID: ZDB-PUB-150715-20|
Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array
Li, G., Li, L., Zhu, L., Xia, J., Wang, L.V.
|Source:||Journal of Biomedical Optics 20: 066010 (Journal)|
|Registered Authors:||Li, Lei|
|PubMed:||26112369 Full text @ J. Biomed. Opt.|
Li, G., Li, L., Zhu, L., Xia, J., Wang, L.V. (2015) Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array. Journal of Biomedical Optics. 20:066010.
ABSTRACTDue to their low cost, hand-held convenience, wide selection of bandwidths, and ultrasound imaging capability, linear ultrasonic transducer arrays have been widely studied for photoacoustic computed tomography (PACT). As linear-array PACT suffers from a limited view, full-view imaging requires either the transducer or the object to be rotated. So far, both the central frequencies and bandwidth of linear transducer arrays applied in full-view PACT are low, limiting the spatial resolutions of the reconstructed images. Here, we present a multiview high-frequency PACT imaging system implemented with a commercial 40-MHz central frequency linear transducer array. By rotating the object through multiple angles with respect to the linear transducer array, we acquired full-view photoacoustic pressure measurements. Further, to quantify the unipolar initial pressures and overcome the limitations of the single-view Hilbert transformation, we developed a multiview Hilbert transformation method. The in-plane spatial resolution of this full-view linear-array PACT was quantified to be isotropically 60 μm within a 10×10 mm² field of view. The system was demonstrated by imaging both a leaf skeleton and a zebrafish in vivo.
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