ZFIN ID: ZDB-PUB-150715-20
Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array
Li, G., Li, L., Zhu, L., Xia, J., Wang, L.V.
Date: 2015
Source: Journal of Biomedical Optics   20: 066010 (Journal)
Registered Authors: Li, Lei
Keywords: none
MeSH Terms:
  • Algorithms
  • Models, Biological
  • Phantoms, Imaging
  • Photoacoustic Techniques/instrumentation*
  • Photoacoustic Techniques/methods*
  • Plant Leaves
  • Tomography, X-Ray Computed/instrumentation*
  • Tomography, X-Ray Computed/methods*
  • Transducers*
PubMed: 26112369 Full text @ J. Biomed. Opt.
Due to their low cost, hand-held convenience, wide selection of bandwidths, and ultrasound imaging capability, linear ultrasonic transducer arrays have been widely studied for photoacoustic computed tomography (PACT). As linear-array PACT suffers from a limited view, full-view imaging requires either the transducer or the object to be rotated. So far, both the central frequencies and bandwidth of linear transducer arrays applied in full-view PACT are low, limiting the spatial resolutions of the reconstructed images. Here, we present a multiview high-frequency PACT imaging system implemented with a commercial 40-MHz central frequency linear transducer array. By rotating the object through multiple angles with respect to the linear transducer array, we acquired full-view photoacoustic pressure measurements. Further, to quantify the unipolar initial pressures and overcome the limitations of the single-view Hilbert transformation, we developed a multiview Hilbert transformation method. The in-plane spatial resolution of this full-view linear-array PACT was quantified to be isotropically 60  μm within a 10×10  mm² field of view. The system was demonstrated by imaging both a leaf skeleton and a zebrafish in vivo.