ZFIN ID: ZDB-PUB-150502-8
Signaling networks organizing regenerative growth of the zebrafish fin
Wehner, D., Weidinger, G.
Date: 2015
Source: Trends in genetics : TIG   31(6): 336-343 (Review)
Registered Authors: Wehner, Daniel, Weidinger, Gilbert
Keywords: Wnt, fin regeneration, growth, signaling pathways, zebrafish, β-catenin
MeSH Terms:
  • Amputation
  • Animal Fins/metabolism*
  • Animal Fins/physiology
  • Animal Fins/surgery
  • Animals
  • Gene Expression
  • Gene Regulatory Networks*
  • Models, Genetic
  • Regeneration/genetics*
  • Signal Transduction/genetics*
  • Zebrafish/genetics*
  • Zebrafish/physiology
  • Zebrafish Proteins/genetics
PubMed: 25929514 Full text @ Trends Genet.
In contrast to mammals, adult salamanders and fish can completely regenerate their appendages after amputation. The cellular and molecular mechanisms underlying this fascinating phenomenon are beginning to emerge, including substantial progress in the identification of signals that control regenerative growth of the zebrafish caudal fin. Despite the fairly simple architecture of the fin, the regulation of its regeneration is complex. Many signals, including fibroblast growth factor (FGF), Wnt, Hedgehog (Hh), retinoic acid (RA), Notch, bone morphogenic protein (BMP), activin, and insulin-like growth factor (IGF), are required for regeneration. Much work needs to be done to dissect tissue-specific functions of these pathways and how they interact, but Wnt/β-catenin signaling is already emerging as a central player. Surprisingly, Wnt/β-catenin signaling appears to largely indirectly control epidermal patterning, progenitor cell proliferation, and osteoblast maturation via regulation of a multitude of secondary signals.