PUBLICATION
Watching eyes take shape
- Authors
- Bazin-Lopez, N., Valdivia, L.E., Wilson, S.W., Gestri, G.
- ID
- ZDB-PUB-150311-16
- Date
- 2015
- Source
- Current opinion in genetics & development 32C: 73-79 (Other)
- Registered Authors
- Bazin-Lopez, Naiara, Gestri, Gaia, Valdivia, Leonardo, Wilson, Steve
- Keywords
- none
- MeSH Terms
-
- Vertebrates/embryology*
- Eye/embryology*
- Animals
- Gene Expression Regulation, Developmental/physiology*
- Organogenesis/physiology*
- Models, Biological*
- Zebrafish
- Embryonic Stem Cells/physiology*
- Ectoderm/embryology*
- Species Specificity
- PubMed
- 25748250 Full text @ Curr. Opin. Genet. Dev.
Citation
Bazin-Lopez, N., Valdivia, L.E., Wilson, S.W., Gestri, G. (2015) Watching eyes take shape. Current opinion in genetics & development. 32C:73-79.
Abstract
Vertebrate eye formation is a multistep process requiring coordinated inductive interactions between neural and non-neural ectoderm and underlying mesendoderm. The induction and shaping of the eyes involves an elaborate cellular choreography characterized by precise changes in cell shape coupled with complex cellular and epithelial movements. Consequently, the forming eye is an excellent model to study the cellular mechanisms underlying complex tissue morphogenesis. Using examples largely drawn from recent studies of optic vesicle formation in zebrafish and in cultured embryonic stem cells, in this short review, we highlight some recent advances in our understanding of the events that shape the vertebrate eye.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping