ZFIN ID: ZDB-PUB-150227-1
Redox imaging using genetically encoded redox indicators in zebrafish and mice
Breckwoldt, M.O., Wittmann, C., Misgeld, T., Kerschensteiner, M., Grabher, C.
Date: 2015
Source: Biological chemistry   396(5): 511-22 (Review)
Registered Authors: Grabher, Clemens, Wittmann, Christine
Keywords: none
MeSH Terms:
  • Animals
  • Biosensing Techniques/methods*
  • Green Fluorescent Proteins/genetics*
  • Mice
  • Oxidation-Reduction
  • Reactive Oxygen Species/metabolism*
  • Signal Transduction
  • Zebrafish
PubMed: 25720068 Full text @ Biol. Chem.
Abstract Redox signals have emerged as important regulators of cellular physiology and pathology. The advent of redox imaging in vertebrate systems now provides the opportunity to dynamically visualize redox signaling during development and disease. In this review we summarize recent advances in the generation of genetically encoded redox indicators (GERIs), introduce new redox imaging strategies and highlight key publications in the field of vertebrate redox imaging. We also discuss the limitations and future potential of in vivo redox imaging in zebrafish and mice.