PUBLICATION
Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio)
- Authors
- Cooper, T.K., Murray, K.N., Spagnoli, S., Spitsbergen, J.M.
- ID
- ZDB-PUB-140611-5
- Date
- 2015
- Source
- Veterinary Pathology 52(2): 388-92 (Journal)
- Registered Authors
- Murray, Katy, Spitsbergen, Jan
- Keywords
- chordomas, intestinal, vertebral, zebrafish
- MeSH Terms
-
- Animals
- Chordoma/pathology
- Chordoma/veterinary*
- Female
- Fish Diseases/pathology*
- Intestinal Neoplasms/pathology
- Intestinal Neoplasms/veterinary*
- Male
- Spinal Neoplasms/pathology
- Spinal Neoplasms/veterinary*
- Zebrafish
- PubMed
- 24913269 Full text @ Vet. Pathol.
Citation
Cooper, T.K., Murray, K.N., Spagnoli, S., Spitsbergen, J.M. (2015) Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio). Veterinary Pathology. 52(2):388-92.
Abstract
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other nonvisceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping