ZFIN ID: ZDB-PUB-140611-5
Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio)
Cooper, T.K., Murray, K.N., Spagnoli, S., Spitsbergen, J.M.
Date: 2015
Source: Veterinary Pathology 52(2): 388-92 (Journal)
Registered Authors: Murray, Katy, Spitsbergen, Jan
Keywords: chordomas, intestinal, vertebral, zebrafish
MeSH Terms: Animals; Chordoma/pathology; Chordoma/veterinary*; Female; Fish Diseases/pathology* (all 11) expand
PubMed: 24913269 Full text @ Vet. Pathol.
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ABSTRACT
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other nonvisceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.
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