Baker, T.R., Peterson, R.E., and Heideman, W. (2014) Using zebrafish as a model system for studying the transgenerational effects of dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 138(2):403-411.
2,3,7,8 Tetrachlorodibenzo-p-dioxin (TCDD) has been associated with many disease states in humans. A rising concern is that exposure early in life can
lead to adult toxicity and toxicity in subsequent generations. Juvenile zebrafish exposed to TCDD (50 pg/ml in water; 1 h
exposure) at 3 and 7 weeks post fertilization showed toxicity only later in adulthood. We have maintained the offspring of
these exposed F0 fish to determine whether we could find adverse affects in the next two generations of F1 and F2 offspring. TCDD exposure produced a significantly higher female:male ratio in all three generations. Scoliosis-like axial
skeleton abnormalities, not normally observed in controls, were present in the F1 and F2 generations descended from the treated F0 founders. Egg release and fertilization success were reduced in the TCDD lineage F1 and F2 generations. This reduction in fertility in the TCDD lineage F2 generation could be attributed to alterations in the F2 males. Using zebrafish as a model allowed the simultaneous maintenance of different generations with relatively small space
and costs. The zebrafish showed clear signs of transgenerational responses persisting into generations never directly exposed
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