PUBLICATION

Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain

Authors
Kishimoto, N., Asakawa, K., Madelaine, R., Blader, P., Kawakami, K., and Sawamoto, K.
ID
ZDB-PUB-130611-37
Date
2013
Source
Nature Neuroscience   16(7): 884-8 (Journal)
Registered Authors
Blader, Patrick, Kawakami, Koichi, Kishimoto, Norihito
Keywords
none
MeSH Terms
  • Age Factors
  • Amino Acids/metabolism
  • Amino Acids/pharmacology
  • Animals
  • Animals, Genetically Modified
  • Catheter Ablation
  • Cerebral Ventricles/metabolism
  • Dipeptides/pharmacology
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors/pharmacology
  • Epithelium/injuries
  • Epithelium/physiology
  • Functional Laterality/genetics
  • Functional Laterality/physiology*
  • Green Fluorescent Proteins/genetics
  • Green Fluorescent Proteins/metabolism
  • HSP70 Heat-Shock Proteins/metabolism
  • Injections, Intraventricular
  • Locomotion/drug effects
  • Locomotion/physiology
  • Nerve Tissue Proteins/metabolism
  • Neurons/physiology*
  • Odorants
  • Olfactory Bulb/cytology*
  • Olfactory Bulb/physiology
  • Olfactory Pathways/cytology
  • Olfactory Pathways/physiology*
  • Zebrafish
  • Zebrafish Proteins/genetics
PubMed
23685722 Full text @ Nat. Neurosci.
Abstract

The vertebrate brain is anatomically and functionally asymmetric. The left and right cerebral hemispheres harbor neural stem cell niches at the ventricular-subventricular zone (V-SVZ) of the ventricular walls, where new neurons are continuously generated throughout life. However, any interhemispheric asymmetry of neural stem cell niches remains unclear. We performed gene-trap screens in adult zebrafish to identify genes that are differentially expressed in the two hemispheres and found that adult-born neurons expressing the neural zinc-finger protein Myt1 exist predominantly in the left V-SVZ. This lateralization could be reversed by left olfactory sensory deprivationinduced inactivation of Notch signaling. The olfactory behavioral preference for attractive amino acids was also impaired by sensory deprivation of the left olfactory system, but not of the right olfactory system. Our findings suggest that olfactory input generates interhemispheric differences in the fate of adult-born neurons in the zebrafish brain.

Genes / Markers
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Human Disease / Model Data
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Fish
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Errata and Notes