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ZFIN ID: ZDB-PUB-130117-3
Sequential transfer of left-right information during vertebrate embryo development
Raya, A., and Izpisúa Belmonte, J.C.
Date: 2004
Source: Current opinion in genetics & development   14(5): 575-581 (Review)
Registered Authors: Izpisúa Belmonte, Juan Carlos, Raya, Angel
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning*
  • Gene Expression Regulation, Developmental
  • Humans
  • Mesoderm/metabolism
  • Nodal Protein
  • Signal Transduction
  • Transforming Growth Factor beta/genetics
  • Transforming Growth Factor beta/metabolism
  • Vertebrates/embryology*
  • Vertebrates/metabolism*
PubMed: 15380250 Full text @ Curr. Opin. Genet. Dev.

The establishment of left–right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.