header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-020725-22
Raya, Angel
Email: araya@ibecbarcelona.eu
URL: http://www.ibecbarcelona.eu/component/option,com_jresearch/Itemid,39/id,2/task,show/view,team/
Affiliation: Raya Lab
Address: Control of Stem Cell Potency Laboratory Institute for Bioengineering of Catalonia (IBEC) Barcelona Science Park, Helix building Baldiri Reixac 15-21 08028 Barcelona, Spain
Country: United States
Phone: +34 93 402 0537
Fax: +34 93 402 0183
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
2010-present: Group Leader, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain.
2008-present: Group Leader, Networking Center of Biomedical Research in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN).
2006-2009: Scientific Coordinator, Center of Regenerative Medicine in Barcelona (CMRB), Barcelona, Spain.
2006-present: ICREA Research Professor.
2004-2006: Senior Research Associate. Gene Expression Laboratory. Salk Institute for Biological Studies, La Jolla, CA, USA. Supervisor: Juan Carlos Izpisúa-Belmonte.
2000-2004: Research Associate. Gene Expression Laboratory. Salk Institute for Biological Studies, La Jolla, CA, USA. Supervisor: Juan Carlos Izpisúa-Belmonte.
1999-2000: Senior Research Associate. Molecular Pathology Unit. Instituto de Investigaciones Citológicas, FVIB. Valencia, Spain. Supervisor: Juan Saus.
1996: Assistant Professor. Department of Physiology, University of Valencia, Spain.
1995-1999: Postdoctoral Research Fellow. Molecular Pathology Unit. Instituto de Investigaciones Citológicas, FVIB. Valencia, Spain. Supervisor: Juan Saus.
1994-1995: Special Project Associate. Peripheral Nerve Center, Department of Neurology, Mayo Clinic, Rochester, MN, USA. Supervisor: Phillip A. Low.
1991-1995: Graduate student. Department of Physiology, University of Valencia, Spain. Supervisor: Joaquín Romá.
1990: MD, University of Valencia, Spain

Research interests:
Our laboratory employs a multipronged approach to address one basic question: How can a discrete and defined degree of developmental potency be imposed onto a somatic cell so that it regains the ability to regenerate a functional tissue or structure? For this purpose, we use in vivo approaches in animal models (zebrafish heart regeneration), as well as cell-based paradigms built around human pluripotent stem cells.


PUBLICATIONS
Uroz, M., Garcia-Puig, A., Tekeli, I., Elosegui-Artola, A., Abenza, J.F., Marín-Llauradó, A., Pujals, S., Conte, V., Albertazzi, L., Roca-Cusachs, P., Raya, Á., Trepat, X. (2019) Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium. Nature Materials. 18(9):1015-1023
Tekeli, I., Garcia-Puig, A., Notari, M., García-Pastor, C., Aujard, I., Jullien, L., Raya, A. (2017) Fate predetermination of cardiac myocytes during zebrafish heart regeneration. Open Biology. 7(6)
Bedford-Guaus, S.J., Chauvigné, F., Mejía-Ramírez, E., Martí, M., Ventura-Rubio, A., Raya, Á., Cerdà, J., Veiga, A. (2016) Expression of the T85A mutant of zebrafish aquaporin 3b improves post-thaw survival of cryopreserved early mammalian embryos. Zygote (Cambridge, England). 24(6):839-847
Tekeli, I., Aujard, I., Trepat, X., Jullien, L., Raya, A., Zalvidea, D. (2016) Long-term in vivo single-cell lineage tracing of deep structures using three-photon activation.. Light, science & applications. 5:e16084
Sleep, E., Boué, S., Jopling, C., Raya, M., Raya, A., and Izpisúa Belmonte, J.C. (2010) Transcriptomics approach to investigate zebrafish heart regeneration. Journal of cardiovascular medicine (Hagerstown, Md.). 11(5):369-380
Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., and Izpisúa Belmonte, J.C. (2010) Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 464(7288):606-609
Raya, A., and Izpisúa Belmonte, J.C. (2008) Insights into the establishment of left-right asymmetries in vertebrates. Birth defects research. Part C, Embryo today : reviews. 84(2):81-94
Ribeiro, I., Kawakami, Y., Buscher, D., Raya, A., Rodriguez-Leon, J., Morita, M., Rodriguez Esteban, C., and Izpisua Belmonte, J.C. (2007) Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling. PLoS One. 2(1):e398
Matsui, T., Raya, A., Callol-Massot, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2007) miles-apart-Mediated regulation of cell-fibronectin interaction and myocardial migration in zebrafish. Nature clinical practice. Cardiovascular medicine. 4(1):S77-S82
Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., and Izpisúa Belmonte, J.C. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nature Genetics. 38(11):1316-1322
Raya, A., and Izpisúa Belmonte, J.C. (2006) Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration. Nature reviews. Genetics. 7(4):283-293
Kawakami, Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2005) Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature. 435(7039):165-171
Matsui, T., Raya, A., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C. (2005) Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes & Development. 19(1):164-175
Raya, A., and Izpisúa Belmonte, J.C. (2004) Sequential transfer of left-right information during vertebrate embryo development. Current opinion in genetics & development. 14(5):575-581
Huang, Q., Raya, A., DeJesus, P., Chao, S.H., Quon, K.C., Caldwell, J.S., Chanda, S.K., Izpisúa Belmonte, J.C., and Schultz, P.G. (2004) Identification of p53 regulators by genome-wide functional analysis. Proceedings of the National Academy of Sciences of the United States of America. 101(10):3456-3461
Raya, A., Consiglio, A., Kawakami, Y., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2004) The zebrafish as a model of heart regeneration. Cloning and stem cells. 6(4):345-351
Timmerman, L.A., Grego-Bessa, J., Raya, A., Bertran, E., Perez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., McCormick, F., Izpisúa Belmonte, J.C., and De La Pompa, J.L. (2004) Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes & Development. 18(1):99-115
Raya, A., Koth, C.M., Büscher, D., Kawakami, Y., Itoh, T., Raya, R.M., Sternick, G., Tsai, H.J., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2003) Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. (Suppl. 1) 100:11889-11895
Kawakami, Y., Rodriguez-Leon, J., Koth, C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez-Esteban, C., Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H., and Izpisúa Belmonte, J.C. (2003) MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nature cell biology. 5(6):513-519
Raya, A., Kawakami, Y., Rodriguez-Esteban, C., Büscher, D., Koth, C.M., Itoh, T., Morita, M., Raya, R.M., Dubova, I., Bessa, J.G., de la Pompa, J.L., and Izpisúa Belmonte, J.C. (2003) Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes & Development. 17(10):1213-1218
Ng, J.K., Kawakami, Y., Büscher, D., Raya, A., Itoh, T., Koth, C.M., Rodriguez-Esteban, C., Rodríguez-León, J., Garrity, D.M., Fishman, M.C., and Izpisúa Belmonte, J.C. (2002) The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Development (Cambridge, England). 129(22):5161-5170

NON-ZEBRAFISH PUBLICATIONS
Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells. McLenachan S, Menchón C, Raya A, Consiglio A, Edel MJ. Stem Cells Dev. 2012 Oct 10;21(15):2891-9. doi: 10.1089/scd.2012.0190

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease. Sánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I, Jiménez-Delgado S, Caig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A, Raya A. EMBO Mol Med. 2012 May;4(5):380-95. doi: 10.1002/emmm.201200215.

Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells. Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A, Izpisua Belmonte JC. Hum Gene Ther. 2012 Jan;23(1):56-69. doi: 10.1089/hum.2011.054.

Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. Fütterer A, Raya A, Llorente M, Izpisúa-Belmonte JC, de la Pompa JL, Klatt P, Martínez-A C. Cell Death Differ. 2012 Jan;19(1):132-43. doi: 10.1038/cdd.2011.62.

Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH, Verma IM. Stem Cells. 2011 Jul;29(7):1158-64. doi: 10.1002/stem.657.
Turning human epidermis into pancreatic endoderm. Santamaria P, Rodriguez-Piza I, Clemente-Casares X, Yamanouchi J, Mulero-Perez L, Aasen T, Raya A, Izpisua Belmonte JC. Rev Diabet Stud. 2010 Summer;7(2):158-67. doi: 10.1900/RDS.2010.7.158.

Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents. Bayes-Genis A, Soler-Botija C, Farré J, Sepúlveda P, Raya A, Roura S, Prat-Vidal C, Gálvez-Montón C, Montero JA, Büscher D, Izpisúa Belmonte JC. J Mol Cell Cardiol. 2010 Nov;49(5):771-80. doi: 10.1016/j.yjmcc.2010.08.010.

Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Edel MJ, Menchon C, Menendez S, Consiglio A, Raya A, Izpisua Belmonte JC. Genes Dev. 2010 Mar 15;24(6):561-73. doi: 10.1101/gad.1876710.

A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells. Raya A, Rodríguez-Pizà I, Navarro S, Richaud-Patin Y, Guenechea G, Sánchez-Danés A, Consiglio A, Bueren J, Izpisúa Belmonte JC. Nat Protoc. 2010 Apr;5(4):647-60. doi: 10.1038/nprot.2010.9.

Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions. Rodríguez-Pizà I, Richaud-Patin Y, Vassena R, González F, Barrero MJ, Veiga A, Raya A, Izpisúa Belmonte JC. Stem Cells. 2010 Jan;28(1):36-44. doi: 10.1002/stem.248.

Embryonic stem cell-like cells derived from adult human testis. Mizrak SC, Chikhovskaya JV, Sadri-Ardekani H, van Daalen S, Korver CM, Hovingh SE, Roepers-Gajadien HL, Raya A, Fluiter K, de Reijke TM, de la Rosette JJ, Knegt AC, Belmonte JC, van der Veen F, de Rooij DG, Repping S, van Pelt AM. Hum Reprod. 2010 Jan;25(1):158-67. doi: 10.1093/humrep/dep354.

Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Giorgetti A, Montserrat N, Aasen T, Gonzalez F, Rodríguez-Pizà I, Vassena R, Raya A, Boué S, Barrero MJ, Corbella BA, Torrabadella M, Veiga A, Izpisua Belmonte JC. Cell Stem Cell. 2009 Oct 2;5(4):353-7. doi: 10.1016/j.stem.2009.09.008.

Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Izpisúa Belmonte JC. Nature. 2009 Aug 27;460(7259):1140-4. doi: 10.1038/nature08311.
Stem cell research in Spain: if only they were windmills... Raya A, Izpisúa Belmonte JC. Cell Stem Cell. 2009 Jun 5;4(6):483-6. doi: 10.1016/j.stem.2009.05.016.

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Raya A, Rodríguez-Pizà I, Guenechea G, Vassena R, Navarro S, Barrero MJ, Consiglio A, Castellà M, Río P, Sleep E, González F, Tiscornia G, Garreta E, Aasen T, Veiga A, Verma IM, Surrallés J, Bueren J, Izpisúa Belmonte JC. Nature. 2009 Jul 2;460(7251):53-9. doi: 10.1038/nature08129.

Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts. Raya A, Rodríguez-Pizà I, Arán B, Consiglio A, Barri PN, Veiga A, Izpisúa Belmonte JC. Cold Spring Harb Symp Quant Biol. 2008;73:127-35. doi: 10.1101/sqb.2008.73.038.

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Aasen T, Raya A, Barrero MJ, Garreta E, Consiglio A, Gonzalez F, Vassena R, Bilić J, Pekarik V, Tiscornia G, Edel M, Boué S, Izpisúa Belmonte JC. Nat Biotechnol. 2008 Nov;26(11):1276-84. doi: 10.1038/nbt.1503
Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodríguez-Esteban C, Izpisúa Belmonte JC. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10294-9.

Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodríguez-Esteban C, Izpisúa Belmonte JC. Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S114-22.

Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18455-60.

Unveiling the establishment of left-right asymmetry in the chick embryo. Raya A, Izpisua Belmonte JC. Mech Dev. 2004 Sep;121(9):1043-54.

Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Raya A, Kawakami Y, Rodriguez-Esteban C, Buscher D, Koth CM, Itoh T, Morita M, Raya RM, Dubova I, Bessa JG, de la Pompa JL, Izpisua Belmonte JC. Genes Dev. 2003 May 15;17(10):1213-8.