PUBLICATION
Optogenetics in a transparent animal: circuit function in the larval zebrafish
- Authors
- Portugues, R., Severi, K.E., Wyart, C., and Ahrens, M.B.
- ID
- ZDB-PUB-121220-45
- Date
- 2013
- Source
- Current opinion in neurobiology 23(1): 119-126 (Review)
- Registered Authors
- Severi, Kristen, Wyart, Claire
- Keywords
- none
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology*
- Brain/physiology*
- Larva
- Optogenetics/methods*
- Zebrafish/physiology*
- PubMed
- 23246238 Full text @ Curr. Opin. Neurobiol.
Citation
Portugues, R., Severi, K.E., Wyart, C., and Ahrens, M.B. (2013) Optogenetics in a transparent animal: circuit function in the larval zebrafish. Current opinion in neurobiology. 23(1):119-126.
Abstract
Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific manner. In recent years, such methods have been applied to uncover causal relationships between activity in specified neuronal circuits and behavior in the larval zebrafish. In this small, transparent, genetic model organism, noninvasive manipulation and monitoring of neuronal activity with light is possible throughout the nervous system. Here we review recent work in which these new tools have been applied to zebrafish, and discuss some of the existing challenges of these approaches.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping