Howe, D.G., Bradford, Y.M., Conlin, T., Eagle, A.E., Fashena, D., Frazer, K., Knight, J., Mani, P., Martin, R., Moxon, S.A., Paddock, H., Pich, C., Ramachandran, S., Ruef, B.J., Ruzicka, L., Schaper, K., Shao, X., Singer, A., Sprunger, B., Van Slyke, C.E., and Westerfield, M. (2013) ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics. Nucleic acids research. 41(D1):D854-860.
ZFIN, the Zebrafish Model Organism Database (http://zfin.org), is the central resource for zebrafish genetic, genomic, phenotypic and developmental data. ZFIN curators manually curate
and integrate comprehensive data involving zebrafish genes, mutants, transgenics, phenotypes, genotypes, gene expressions,
morpholinos, antibodies, anatomical structures and publications. Integrated views of these data, as well as data gathered
through collaborations and data exchanges, are provided through a wide selection of web-based search forms. Among the vertebrate
model organisms, zebrafish are uniquely well suited for rapid and targeted generation of mutant lines. The recent rapid production
of mutants and transgenic zebrafish is making management of data associated with these resources particularly important to
the research community. Here, we describe recent enhancements to ZFIN aimed at improving our support for mutant and transgenic
lines, including (i) enhanced mutant/transgenic search functionality; (ii) more expressive phenotype curation methods; (iii)
new downloads files and archival data access; (iv) incorporation of new data loads from laboratories undertaking large-scale
generation of mutant or transgenic lines and (v) new GBrowse tracks for transgenic insertions, genes with antibodies and morpholinos.
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