Liu, Y., Wu, Y., Feng, D., Ye, Q., Yang, X., Liu, X., Gao, C., Wu, M., Chen, D., Zhang, Y., Li, L., and Feng, X. (2011) Optical tracking and biocompatibility assessment of nanoparticles from triblock copolymer encapsulating-dye complexes. Journal of Materials Chemistry. 21:18704-18710.
Optical tracking and biocompatibility study of nanoparticles (NPs) have received lots of attention in nano-research areas. In this paper, PDMAEMA-b-poly(PEGMA)-b-PDMAEMA–fluorescein (DED–F) NPs were synthesized by encapsulating hydrophobic fluorescein in an amphiphilic triblock copolymer DED. DED possessed gene transfection functions as our previous work demonstrated and the encapsulated fluorescein guaranteed the bioimaging capability of DED–F NPs. The bioimaging and biocompatibility assessments were conducted in vitro using PC12 cells and in vivo through the model organism zebrafish. The results demonstrated that DED–F NPs could be internalized by cells without changing the electrophysiological conditions of ion channels on cell membranes. Moreover, the absorption, distribution, metabolism and excretion of DED–F NPs in early developmental zebrafish indicated that these NPs could serve as biocompatible imaging agents in in vivo studies.
No data available
Your Input Welcome
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if
additional information is required.
Oops. Something went wrong. Please try again later.