ZFIN ID: ZDB-PUB-111012-14
Not All Bones are Created Equal - Using Zebrafish and Other Teleost Species in Osteogenesis Research
Apschner, A., Schulte-Merker, S., and Witten, P.E.
Date: 2011
Source: Methods in cell biology   105: 239-255 (Chapter)
Registered Authors: Apschner, Alexander, Schulte-Merker, Stefan, Witten, P. Eckhard
Keywords: acellular, osteoblast, osteoclast, osteogenesis, remodelling, transgenic
MeSH Terms:
  • Animals
  • Animals, Genetically Modified/embryology*
  • Biological Evolution
  • Bone and Bones/embryology*
  • Bone and Bones/metabolism
  • Cartilage/cytology
  • Cartilage/physiology
  • Developmental Biology/methods*
  • Humans
  • Mammals
  • Mice
  • Mutation
  • Osteoclasts/cytology
  • Osteoclasts/physiology
  • Osteocytes/cytology
  • Osteocytes/physiology
  • Osteogenesis*/physiology
  • Phylogeny
  • Zebrafish/embryology
  • Zebrafish/genetics*
PubMed: 21951533 Full text @ Meth. Cell. Biol.
Developmental osteogenesis and pathologies of mineralized tissues are areas of intense investigations in the mammalian field, but different from other areas of organ formation and developmental biology, zebrafish have been somewhat slow in joining the area of bone research. In recent years, however, genetic screens have provided a number of exciting mutants, and transgenic lines have been developed that permit visualization of osteoblasts and osteoclasts in vivo. We here review some of the recent literature and provide examples where insights from studies in zebrafish have complemented the information available from mammalian models or clinical studies. Furthermore, we provide a comparative overview about different forms of bone within the teleost lineage, and between teleosts and mammals.