ZFIN ID: ZDB-PUB-110719-37
Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish
Lawson, N.D., and Wolfe, S.A.
Date: 2011
Source: Developmental Cell 21(1): 48-64 (Review)
Registered Authors: Lawson, Nathan, Wolfe, Scot A.
Keywords: none
MeSH Terms: Animals; Cell Biology; Developmental Biology/methods*; Genetic Techniques*; Models, Biological; Zebrafish/embryology*; Zebrafish/genetics*
PubMed: 21763608 Full text @ Dev. Cell
ABSTRACT
The development of facile forward and reverse genetic approaches has propelled the deconvolution of gene function in biology. While the origins of these techniques reside in the study of single-cell or invertebrate organisms, in many cases these approaches have been applied to vertebrate model systems to gain powerful insights into gene function during embryonic development. This perspective provides a summary of the major forward and reverse genetic approaches that have contributed to the study of vertebrate gene function in zebrafish, which has become an established model for the study of animal development.
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