The challenges of implementing pathogen control strategies for fishes used in biomedical research
- Lawrence, C., Ennis, D.G., Harper, C., Kent, M.L., Murray, K., and Sanders, G.E.
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 155(1): 160-6 (Journal)
- Registered Authors
- Kent, Michael, Lawrence, Christian, Murray, Katy
- MeSH Terms
- Animal Diseases/diagnosis
- Animal Diseases/prevention & control*
- Animal Feed/analysis
- Animals, Laboratory/microbiology
- Animals, Laboratory/parasitology
- Animals, Laboratory/physiology*
- Animals, Laboratory/virology
- Biomedical Research/organization & administration
- Biomedical Research/standards*
- Laboratory Animal Science/standards*
- Specific Pathogen-Free Organisms
- 21726668 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Lawrence, C., Ennis, D.G., Harper, C., Kent, M.L., Murray, K., and Sanders, G.E. (2012) The challenges of implementing pathogen control strategies for fishes used in biomedical research. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 155(1):160-6.
Over the past several decades, a number of fish species, including the zebrafish, medaka, and platyfish/swordtail, have become important models for human health and disease. Despite the increasing prevalence of these and other fish species in research, methods for health maintenance and the management of diseases in laboratory populations of these animals are underdeveloped. There is a growing realization that this trend must change, especially as the use of these species expands beyond developmental biology and more towards experimental applications where the presence of underlying disease may affect the physiology animals used in experiments and potentially compromise research results. Therefore, there is a critical need to develop, improve, and implement strategies for managing health and disease in aquatic research facilities. The purpose of this review is to report the proceedings of a workshop entitled “Animal Health and Disease Management in Research Animals” that was recently held at the 5th Aquatic Animal Models for Human Disease in September 2010 at Corvallis, Oregon to discuss the challenges involved with moving the field forward on this front.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes