PUBLICATION
Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line ganglia development
- Authors
- Liu, Q., Dalman, M.R., Sarmah, S., Chen, S., Chen, Y., Hurlbut, A.K., Spencer, M.A., Pancoe, L., and Marrs, J.A.
- ID
- ZDB-PUB-110602-10
- Date
- 2011
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 240(7): 1716-26 (Journal)
- Registered Authors
- Liu, Qin, Marrs, James A., Sarmah, Swapnalee
- Keywords
- differentiation, statoacoustic ganglia, peripheral nervous system, cranial and lateral line nerves
- MeSH Terms
-
- Animals
- Cadherins/genetics
- Cadherins/metabolism*
- Ganglia/embryology
- Ganglia/metabolism*
- Immunohistochemistry
- In Situ Hybridization
- In Situ Nick-End Labeling
- Lateral Line System/embryology
- Lateral Line System/metabolism*
- Peripheral Nervous System/embryology
- Peripheral Nervous System/metabolism
- Zebrafish/embryology*
- Zebrafish/metabolism*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 21584906 Full text @ Dev. Dyn.
Citation
Liu, Q., Dalman, M.R., Sarmah, S., Chen, S., Chen, Y., Hurlbut, A.K., Spencer, M.A., Pancoe, L., and Marrs, J.A. (2011) Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line ganglia development. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(7):1716-26.
Abstract
Cadherins regulate the vertebrate nervous system development. We previously showed that cadherin-6 message (cdh6) was strongly expressed in the majority of the embryonic zebrafish cranial and lateral line ganglia during their development. Here, we present evidence that cdh6 has specific functions during cranial and lateral line ganglia and nerve development. We analyzed the consequences of cdh6 loss-of-function on cranial ganglion and nerve differentiation in zebrafish embryos. Embryos injected with zebrafish cdh6 specific antisense morpholino oligonucleotides (MOs, which suppress gene expression during development; cdh6 morphant embryos) displayed a specific phenotype, including (i) altered shape and reduced development of a subset of the cranial and lateral line ganglia (e.g., the statoacoustic ganglion and vagal ganglion) and (ii) cranial nerves were abnormally formed. These data illustrate an important role for cdh6 in the formation of cranial ganglia and their nerves.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping